Slow and medium afterhyperpolarizations in maturing rat hippocampal CA1 neurones

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The postnatal evolution of the signals underlying the afterhyperpolarization (slow-AHP and medium-AHP) was studied in rat CA1 hippocampal neurones (P10-16, P17-23 and P > 26) using in vitro slices. Noradrenaline (NA) and signal subtraction were used to decompose the AHP (m-AHP and s-AHP). The amplitude of the s-AHP was found significant between P10-16 and P17-23 cells; the m-AHP showed no significant change. The time to peak of the s-AHP of the P > 26 cells was found to be significantly different from the remaining groups; the m-AHP showed no significant change. The changes in waveform and amplitude of the AHP at this stage were found to be mainly due to the modifications of the slow-AHP.

Original languageEnglish
Pages (from-to)555-558
Number of pages4
Issue number7
Publication statusPublished - 1 Jan 1992



  • Afterhyperpolarization
  • CAI
  • Development
  • Hippocampus
  • Maturation
  • Noradrenaline receptors

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