Slow and medium afterhyperpolarizations in maturing rat hippocampal CA1 neurones

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The postnatal evolution of the signals underlying the afterhyperpolarization (slow-AHP and medium-AHP) was studied in rat CA1 hippocampal neurones (P10-16, P17-23 and P > 26) using in vitro slices. Noradrenaline (NA) and signal subtraction were used to decompose the AHP (m-AHP and s-AHP). The amplitude of the s-AHP was found significant between P10-16 and P17-23 cells; the m-AHP showed no significant change. The time to peak of the s-AHP of the P > 26 cells was found to be significantly different from the remaining groups; the m-AHP showed no significant change. The changes in waveform and amplitude of the AHP at this stage were found to be mainly due to the modifications of the slow-AHP.

Original languageEnglish
Pages (from-to)555-558
Number of pages4
JournalNeuroReport
Volume3
Issue number7
DOIs
Publication statusPublished - 1 Jan 1992

Fingerprint

Neurons
Norepinephrine
In Vitro Techniques

Keywords

  • Afterhyperpolarization
  • CAI
  • Development
  • Hippocampus
  • Maturation
  • Noradrenaline receptors

Cite this

@article{8c4aabc05a284373b39152035a6cef7c,
title = "Slow and medium afterhyperpolarizations in maturing rat hippocampal CA1 neurones",
abstract = "The postnatal evolution of the signals underlying the afterhyperpolarization (slow-AHP and medium-AHP) was studied in rat CA1 hippocampal neurones (P10-16, P17-23 and P > 26) using in vitro slices. Noradrenaline (NA) and signal subtraction were used to decompose the AHP (m-AHP and s-AHP). The amplitude of the s-AHP was found significant between P10-16 and P17-23 cells; the m-AHP showed no significant change. The time to peak of the s-AHP of the P > 26 cells was found to be significantly different from the remaining groups; the m-AHP showed no significant change. The changes in waveform and amplitude of the AHP at this stage were found to be mainly due to the modifications of the slow-AHP.",
keywords = "Afterhyperpolarization, CAI, Development, Hippocampus, Maturation, Noradrenaline receptors",
author = "Costa, {Pedro Freire} and Santos, {Ana Isabel} and Ribeiro, {Maria Alexandra}",
year = "1992",
month = "1",
day = "1",
doi = "10.1097/00001756-199207000-00002",
language = "English",
volume = "3",
pages = "555--558",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott, Williams & Wilkins",
number = "7",

}

TY - JOUR

T1 - Slow and medium afterhyperpolarizations in maturing rat hippocampal CA1 neurones

AU - Costa, Pedro Freire

AU - Santos, Ana Isabel

AU - Ribeiro, Maria Alexandra

PY - 1992/1/1

Y1 - 1992/1/1

N2 - The postnatal evolution of the signals underlying the afterhyperpolarization (slow-AHP and medium-AHP) was studied in rat CA1 hippocampal neurones (P10-16, P17-23 and P > 26) using in vitro slices. Noradrenaline (NA) and signal subtraction were used to decompose the AHP (m-AHP and s-AHP). The amplitude of the s-AHP was found significant between P10-16 and P17-23 cells; the m-AHP showed no significant change. The time to peak of the s-AHP of the P > 26 cells was found to be significantly different from the remaining groups; the m-AHP showed no significant change. The changes in waveform and amplitude of the AHP at this stage were found to be mainly due to the modifications of the slow-AHP.

AB - The postnatal evolution of the signals underlying the afterhyperpolarization (slow-AHP and medium-AHP) was studied in rat CA1 hippocampal neurones (P10-16, P17-23 and P > 26) using in vitro slices. Noradrenaline (NA) and signal subtraction were used to decompose the AHP (m-AHP and s-AHP). The amplitude of the s-AHP was found significant between P10-16 and P17-23 cells; the m-AHP showed no significant change. The time to peak of the s-AHP of the P > 26 cells was found to be significantly different from the remaining groups; the m-AHP showed no significant change. The changes in waveform and amplitude of the AHP at this stage were found to be mainly due to the modifications of the slow-AHP.

KW - Afterhyperpolarization

KW - CAI

KW - Development

KW - Hippocampus

KW - Maturation

KW - Noradrenaline receptors

UR - http://www.scopus.com/inward/record.url?scp=0026749679&partnerID=8YFLogxK

U2 - 10.1097/00001756-199207000-00002

DO - 10.1097/00001756-199207000-00002

M3 - Article

VL - 3

SP - 555

EP - 558

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 7

ER -