Slow and medium afterhyperpolarizations in maturing rat hippocampal CA1 neurones

Pedro Freire Costa; Ana Isabel Santos; Maria Alexandra Ribeiro

doi:10.1097/00001756-199207000-00002

Slow and medium afterhyperpolarizations in maturing rat hippocampal CA1 neurones

Pedro Freire Costa, Ana Isabel Santos, Maria Alexandra Ribeiro

NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The postnatal evolution of the signals underlying the afterhyperpolarization (slow-AHP and medium-AHP) was studied in rat CA1 hippocampal neurones (P_10-16, P_17-23 and P > 26) using in vitro slices. Noradrenaline (NA) and signal subtraction were used to decompose the AHP (m-AHP and s-AHP). The amplitude of the s-AHP was found significant between P_10-16 and P_17-23 cells; the m-AHP showed no significant change. The time to peak of the s-AHP of the P > 26 cells was found to be significantly different from the remaining groups; the m-AHP showed no significant change. The changes in waveform and amplitude of the AHP at this stage were found to be mainly due to the modifications of the slow-AHP.

Original language	English
Pages (from-to)	555-558
Number of pages	4
Journal	NeuroReport
Volume	3
Issue number	7
DOIs	https://doi.org/10.1097/00001756-199207000-00002
Publication status	Published - 1 Jan 1992

Keywords

Afterhyperpolarization
CAI
Development
Hippocampus
Maturation
Noradrenaline receptors

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10.1097/00001756-199207000-00002

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abstract = "The postnatal evolution of the signals underlying the afterhyperpolarization (slow-AHP and medium-AHP) was studied in rat CA1 hippocampal neurones (P10-16, P17-23 and P > 26) using in vitro slices. Noradrenaline (NA) and signal subtraction were used to decompose the AHP (m-AHP and s-AHP). The amplitude of the s-AHP was found significant between P10-16 and P17-23 cells; the m-AHP showed no significant change. The time to peak of the s-AHP of the P > 26 cells was found to be significantly different from the remaining groups; the m-AHP showed no significant change. The changes in waveform and amplitude of the AHP at this stage were found to be mainly due to the modifications of the slow-AHP.",

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AU - Costa, Pedro Freire

AU - Santos, Ana Isabel

AU - Ribeiro, Maria Alexandra

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N2 - The postnatal evolution of the signals underlying the afterhyperpolarization (slow-AHP and medium-AHP) was studied in rat CA1 hippocampal neurones (P10-16, P17-23 and P > 26) using in vitro slices. Noradrenaline (NA) and signal subtraction were used to decompose the AHP (m-AHP and s-AHP). The amplitude of the s-AHP was found significant between P10-16 and P17-23 cells; the m-AHP showed no significant change. The time to peak of the s-AHP of the P > 26 cells was found to be significantly different from the remaining groups; the m-AHP showed no significant change. The changes in waveform and amplitude of the AHP at this stage were found to be mainly due to the modifications of the slow-AHP.

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KW - Maturation

KW - Noradrenaline receptors

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Slow and medium afterhyperpolarizations in maturing rat hippocampal CA1 neurones

Abstract

Keywords

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