SIRT3 deficiency impairs mitochondrial bioenergetics via hyperacetylation of TCA cycle enzymes in chronic heart failure

Yichen Liao; Xuxin Tan; Guanglin Peng; Yan Ren; Ruixue Liu; Haitang Liao; Zhenchun Luo; Zhezhe Cao; Yaguang Wu; Milad Ashrafizadeh; João Conde; Chenyang Duan; Jun Hu; Ruiyan Ma

doi:10.1186/s12967-026-07973-x

SIRT3 deficiency impairs mitochondrial bioenergetics via hyperacetylation of TCA cycle enzymes in chronic heart failure

Yichen Liao, Xuxin Tan, Guanglin Peng, Yan Ren, Ruixue Liu, Haitang Liao, Zhenchun Luo, Zhezhe Cao, Yaguang Wu, Milad Ashrafizadeh, João Conde, Chenyang Duan, Jun Hu, Ruiyan Ma

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Journal of Translational Medicine
DOIs	https://doi.org/10.1186/s12967-026-07973-x
Publication status	E-pub ahead of print - 9 Mar 2026

Access to Document

10.1186/s12967-026-07973-x

s12967-026-07973-x_referenceFinal published version, 1.87 MBLicence: CC BY

Cite this

Liao, Y., Tan, X., Peng, G., Ren, Y., Liu, R., Liao, H., Luo, Z., Cao, Z., Wu, Y., Ashrafizadeh, M., Conde, J., Duan, C., Hu, J., & Ma, R. (2026). SIRT3 deficiency impairs mitochondrial bioenergetics via hyperacetylation of TCA cycle enzymes in chronic heart failure. Journal of Translational Medicine. Advance online publication. https://doi.org/10.1186/s12967-026-07973-x

@article{57f616eb0bf5402781b73f74fdfbed92,

title = "SIRT3 deficiency impairs mitochondrial bioenergetics via hyperacetylation of TCA cycle enzymes in chronic heart failure",

author = "Yichen Liao and Xuxin Tan and Guanglin Peng and Yan Ren and Ruixue Liu and Haitang Liao and Zhenchun Luo and Zhezhe Cao and Yaguang Wu and Milad Ashrafizadeh and Jo{\~a}o Conde and Chenyang Duan and Jun Hu and Ruiyan Ma",

year = "2026",

month = mar,

day = "9",

doi = "10.1186/s12967-026-07973-x",

language = "English",

journal = "Journal of Translational Medicine",

issn = "1479-5876",

publisher = "BioMed Central (BMC)",

}

TY - JOUR

T1 - SIRT3 deficiency impairs mitochondrial bioenergetics via hyperacetylation of TCA cycle enzymes in chronic heart failure

AU - Liao, Yichen

AU - Tan, Xuxin

AU - Peng, Guanglin

AU - Ren, Yan

AU - Liu, Ruixue

AU - Liao, Haitang

AU - Luo, Zhenchun

AU - Cao, Zhezhe

AU - Wu, Yaguang

AU - Ashrafizadeh, Milad

AU - Conde, João

AU - Duan, Chenyang

AU - Hu, Jun

AU - Ma, Ruiyan

PY - 2026/3/9

Y1 - 2026/3/9

U2 - 10.1186/s12967-026-07973-x

DO - 10.1186/s12967-026-07973-x

M3 - Article

C2 - 41803875

SN - 1479-5876

JO - Journal of Translational Medicine

JF - Journal of Translational Medicine

ER -