TY - JOUR
T1 - Singularities of Pyogenic Streptococcal Biofilms – From Formation to Health Implication
AU - Alves-Barroco, Cinthia
AU - Paquete-Ferreira, João
AU - Santos-Silva, Teresa
AU - Fernandes, Alexandra R.
PY - 2020/12/23
Y1 - 2020/12/23
N2 - Biofilms are generally defined as communities of cells involved in a self-produced extracellular matrix adhered to a surface. In biofilms, the bacteria are less sensitive to host defense mechanisms and antimicrobial agents, due to multiple strategies, that involve modulation of gene expression, controlled metabolic rate, intercellular communication, composition, and 3D architecture of the extracellular matrix. These factors play a key role in streptococci pathogenesis, contributing to therapy failure and promoting persistent infections. The species of the pyogenic group together with Streptococcus pneumoniae are the major pathogens belonging the genus Streptococcus, and its biofilm growth has been investigated, but insights in the genetic origin of biofilm formation are limited. This review summarizes pyogenic streptococci biofilms with details on constitution, formation, and virulence factors associated with formation.
AB - Biofilms are generally defined as communities of cells involved in a self-produced extracellular matrix adhered to a surface. In biofilms, the bacteria are less sensitive to host defense mechanisms and antimicrobial agents, due to multiple strategies, that involve modulation of gene expression, controlled metabolic rate, intercellular communication, composition, and 3D architecture of the extracellular matrix. These factors play a key role in streptococci pathogenesis, contributing to therapy failure and promoting persistent infections. The species of the pyogenic group together with Streptococcus pneumoniae are the major pathogens belonging the genus Streptococcus, and its biofilm growth has been investigated, but insights in the genetic origin of biofilm formation are limited. This review summarizes pyogenic streptococci biofilms with details on constitution, formation, and virulence factors associated with formation.
KW - antibiotic resistance
KW - biofilm
KW - quorum-sensing
KW - streptococcal
KW - virulence factors
UR - http://www.scopus.com/inward/record.url?scp=85099033002&partnerID=8YFLogxK
U2 - 10.3389/fmicb.2020.584947
DO - 10.3389/fmicb.2020.584947
M3 - Review article
C2 - 33424785
AN - SCOPUS:85099033002
SN - 1664-302X
VL - 11
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
M1 - 584947
ER -