Single and mixture toxicity of abamectin and difenoconazole to adult zebrafish (Danio rerio)

Ana Letícia Madeira Sanches, Bruna Horvath Vieira, Marina Vanderlei Reghini, Raquel Aparecida Moreira, Emanuela Cristina Freitas, Evaldo L.G. Espíndola, Michiel A. Daam

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Concerns have been raised in recent years on the potential risks related with pesticide mixtures that are likely to be present in agricultural edge-of-field waterbodies. Despite the high use of pesticides in tropical countries like Brazil, studies evaluating pesticide mixtures are especially scarce in the tropics. The insecticide abamectin and the fungicide difenoconazole are the main pesticides intensively used in Brazilian strawberry crop and are hence likely to occur simultaneously. The aim of the present study was therefore to evaluate the toxicity of abamectin, difenoconazole and their mixture to the tropical fish Danio rerio. Laboratory toxicity tests with the individual pesticides indicated 48 h-LC50 values of 59 μg L−1 for abamectin and 1.4 mg L−1 for difenoconazole. Mixtures of the two pesticides revealed a synergistic deviation of the independent action model. Implications of study findings for the aquatic risk assessment of pesticide mixtures, especially in tropical countries and indications for future research are discussed.

Original languageEnglish
Pages (from-to)582-587
Number of pages6
JournalChemosphere
Volume188
DOIs
Publication statusPublished - 1 Jan 2017

Fingerprint

abamectin
Pesticides
Toxicity
pesticide
toxicity
Fungicides
Tropics
fungicide
Insecticides
difenoconazole
toxicity test
Risk assessment
Fish
Crops
insecticide

Keywords

  • Acute toxicity
  • Danio rerio
  • Pesticide mixture
  • Tropics

Cite this

Sanches, A. L. M., Vieira, B. H., Reghini, M. V., Moreira, R. A., Freitas, E. C., Espíndola, E. L. G., & Daam, M. A. (2017). Single and mixture toxicity of abamectin and difenoconazole to adult zebrafish (Danio rerio). Chemosphere, 188, 582-587. https://doi.org/10.1016/j.chemosphere.2017.09.027
Sanches, Ana Letícia Madeira ; Vieira, Bruna Horvath ; Reghini, Marina Vanderlei ; Moreira, Raquel Aparecida ; Freitas, Emanuela Cristina ; Espíndola, Evaldo L.G. ; Daam, Michiel A. / Single and mixture toxicity of abamectin and difenoconazole to adult zebrafish (Danio rerio). In: Chemosphere. 2017 ; Vol. 188. pp. 582-587.
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Sanches, ALM, Vieira, BH, Reghini, MV, Moreira, RA, Freitas, EC, Espíndola, ELG & Daam, MA 2017, 'Single and mixture toxicity of abamectin and difenoconazole to adult zebrafish (Danio rerio)', Chemosphere, vol. 188, pp. 582-587. https://doi.org/10.1016/j.chemosphere.2017.09.027

Single and mixture toxicity of abamectin and difenoconazole to adult zebrafish (Danio rerio). / Sanches, Ana Letícia Madeira; Vieira, Bruna Horvath; Reghini, Marina Vanderlei; Moreira, Raquel Aparecida; Freitas, Emanuela Cristina; Espíndola, Evaldo L.G.; Daam, Michiel A.

In: Chemosphere, Vol. 188, 01.01.2017, p. 582-587.

Research output: Contribution to journalArticle

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T1 - Single and mixture toxicity of abamectin and difenoconazole to adult zebrafish (Danio rerio)

AU - Sanches, Ana Letícia Madeira

AU - Vieira, Bruna Horvath

AU - Reghini, Marina Vanderlei

AU - Moreira, Raquel Aparecida

AU - Freitas, Emanuela Cristina

AU - Espíndola, Evaldo L.G.

AU - Daam, Michiel A.

N1 - sem pdf conforme despacho. Sao Paulo Research Foundation (Fundacao de Amparo a Pesquisa do Estado de sao Paulo - FAPESP) for their financial support (Process number: 2014/14621-0). Brazilian government through the Special Visiting Researcher program (MEC/MCTI/CAPES/CNPq/FAPs reference 402392/2013-2). Portuguese government (FCT) through a postdoc grant for the last author (SFRH/BPD/109199/2015) and the research unit UID/AMB/04085/2013 (CENSE).

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Concerns have been raised in recent years on the potential risks related with pesticide mixtures that are likely to be present in agricultural edge-of-field waterbodies. Despite the high use of pesticides in tropical countries like Brazil, studies evaluating pesticide mixtures are especially scarce in the tropics. The insecticide abamectin and the fungicide difenoconazole are the main pesticides intensively used in Brazilian strawberry crop and are hence likely to occur simultaneously. The aim of the present study was therefore to evaluate the toxicity of abamectin, difenoconazole and their mixture to the tropical fish Danio rerio. Laboratory toxicity tests with the individual pesticides indicated 48 h-LC50 values of 59 μg L−1 for abamectin and 1.4 mg L−1 for difenoconazole. Mixtures of the two pesticides revealed a synergistic deviation of the independent action model. Implications of study findings for the aquatic risk assessment of pesticide mixtures, especially in tropical countries and indications for future research are discussed.

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U2 - 10.1016/j.chemosphere.2017.09.027

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JO - Chemosphere

JF - Chemosphere

SN - 0045-6535

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Sanches ALM, Vieira BH, Reghini MV, Moreira RA, Freitas EC, Espíndola ELG et al. Single and mixture toxicity of abamectin and difenoconazole to adult zebrafish (Danio rerio). Chemosphere. 2017 Jan 1;188:582-587. https://doi.org/10.1016/j.chemosphere.2017.09.027