TY - JOUR
T1 - Single and mixture toxicity of abamectin and difenoconazole to adult zebrafish (Danio rerio)
AU - Sanches, Ana Letícia Madeira
AU - Vieira, Bruna Horvath
AU - Reghini, Marina Vanderlei
AU - Moreira, Raquel Aparecida
AU - Freitas, Emanuela Cristina
AU - Espíndola, Evaldo L.G.
AU - Daam, Michiel A.
N1 - sem pdf conforme despacho.
Sao Paulo Research Foundation (Fundacao de Amparo a Pesquisa do Estado de sao Paulo - FAPESP) for their financial support (Process number: 2014/14621-0).
Brazilian government through the Special Visiting Researcher program (MEC/MCTI/CAPES/CNPq/FAPs reference 402392/2013-2).
Portuguese government (FCT) through a postdoc grant for the last author (SFRH/BPD/109199/2015) and the research unit UID/AMB/04085/2013 (CENSE).
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Concerns have been raised in recent years on the potential risks related with pesticide mixtures that are likely to be present in agricultural edge-of-field waterbodies. Despite the high use of pesticides in tropical countries like Brazil, studies evaluating pesticide mixtures are especially scarce in the tropics. The insecticide abamectin and the fungicide difenoconazole are the main pesticides intensively used in Brazilian strawberry crop and are hence likely to occur simultaneously. The aim of the present study was therefore to evaluate the toxicity of abamectin, difenoconazole and their mixture to the tropical fish Danio rerio. Laboratory toxicity tests with the individual pesticides indicated 48 h-LC50 values of 59 μg L−1 for abamectin and 1.4 mg L−1 for difenoconazole. Mixtures of the two pesticides revealed a synergistic deviation of the independent action model. Implications of study findings for the aquatic risk assessment of pesticide mixtures, especially in tropical countries and indications for future research are discussed.
AB - Concerns have been raised in recent years on the potential risks related with pesticide mixtures that are likely to be present in agricultural edge-of-field waterbodies. Despite the high use of pesticides in tropical countries like Brazil, studies evaluating pesticide mixtures are especially scarce in the tropics. The insecticide abamectin and the fungicide difenoconazole are the main pesticides intensively used in Brazilian strawberry crop and are hence likely to occur simultaneously. The aim of the present study was therefore to evaluate the toxicity of abamectin, difenoconazole and their mixture to the tropical fish Danio rerio. Laboratory toxicity tests with the individual pesticides indicated 48 h-LC50 values of 59 μg L−1 for abamectin and 1.4 mg L−1 for difenoconazole. Mixtures of the two pesticides revealed a synergistic deviation of the independent action model. Implications of study findings for the aquatic risk assessment of pesticide mixtures, especially in tropical countries and indications for future research are discussed.
KW - Acute toxicity
KW - Danio rerio
KW - Pesticide mixture
KW - Tropics
UR - http://www.scopus.com/inward/record.url?scp=85029301213&partnerID=8YFLogxK
U2 - 10.1016/j.chemosphere.2017.09.027
DO - 10.1016/j.chemosphere.2017.09.027
M3 - Article
C2 - 28917210
AN - SCOPUS:85029301213
VL - 188
SP - 582
EP - 587
JO - Chemosphere
JF - Chemosphere
SN - 0045-6535
ER -