Short synthesis of the natural product 3 beta-hydroxy-labd-8(17)-en-15-oic acid via microbial transformation of labdanolic acid

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Starting from labdanolic acid, extracted from Cistus ladaniferus plant, the first synthesis of the natural product 3b-hydroxy-labd-8(17)-en-15-oic acid was achieved, via microbial transformation mediated by Penicillium janczewskii followed by dehydration. The structure of a new labdane diterpene, namely 3 beta-hydroxy-labdanolic acid, was elucidated by X-ray crystallography and spectroscopic data. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
Original languageUnknown
Pages (from-to)165-169
JournalPhytochemistry Letters
Issue number2
Publication statusPublished - 1 Jan 2013

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