Short synthesis of the natural product 3 beta-hydroxy-labd-8(17)-en-15-oic acid via microbial transformation of labdanolic acid

Cristina Maria Pereira

doi:10.1016/j.phytol.2012.12.005

Short synthesis of the natural product 3 beta-hydroxy-labd-8(17)-en-15-oic acid via microbial transformation of labdanolic acid

Cristina Maria Pereira

Instituto de Tecnologia Química e Biológica António Xavier (ITQB)

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Starting from labdanolic acid, extracted from Cistus ladaniferus plant, the first synthesis of the natural product 3b-hydroxy-labd-8(17)-en-15-oic acid was achieved, via microbial transformation mediated by Penicillium janczewskii followed by dehydration. The structure of a new labdane diterpene, namely 3 beta-hydroxy-labdanolic acid, was elucidated by X-ray crystallography and spectroscopic data. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.

Original language	Unknown
Pages (from-to)	165-169
Journal	Phytochemistry Letters
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/j.phytol.2012.12.005
Publication status	Published - 1 Jan 2013

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10.1016/j.phytol.2012.12.005

Cite this

@article{b503fca3f148476d80159e5ae1811022,

title = "Short synthesis of the natural product 3 beta-hydroxy-labd-8(17)-en-15-oic acid via microbial transformation of labdanolic acid",

abstract = "Starting from labdanolic acid, extracted from Cistus ladaniferus plant, the first synthesis of the natural product 3b-hydroxy-labd-8(17)-en-15-oic acid was achieved, via microbial transformation mediated by Penicillium janczewskii followed by dehydration. The structure of a new labdane diterpene, namely 3 beta-hydroxy-labdanolic acid, was elucidated by X-ray crystallography and spectroscopic data. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.",

keywords = "Diterpenes, Hydroxylation, Biotransformation, Labdanolic acid, Fungus, Penicillium janczewskii",

author = "Pereira, {Cristina Maria}",

year = "2013",

month = jan,

day = "1",

doi = "10.1016/j.phytol.2012.12.005",

language = "Unknown",

volume = "6",

pages = "165--169",

journal = "Phytochemistry Letters",

issn = "1874-3900",

publisher = "Elsevier Science B.V., Amsterdam.",

number = "2",

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TY - JOUR

T1 - Short synthesis of the natural product 3 beta-hydroxy-labd-8(17)-en-15-oic acid via microbial transformation of labdanolic acid

AU - Pereira, Cristina Maria

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Starting from labdanolic acid, extracted from Cistus ladaniferus plant, the first synthesis of the natural product 3b-hydroxy-labd-8(17)-en-15-oic acid was achieved, via microbial transformation mediated by Penicillium janczewskii followed by dehydration. The structure of a new labdane diterpene, namely 3 beta-hydroxy-labdanolic acid, was elucidated by X-ray crystallography and spectroscopic data. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.

AB - Starting from labdanolic acid, extracted from Cistus ladaniferus plant, the first synthesis of the natural product 3b-hydroxy-labd-8(17)-en-15-oic acid was achieved, via microbial transformation mediated by Penicillium janczewskii followed by dehydration. The structure of a new labdane diterpene, namely 3 beta-hydroxy-labdanolic acid, was elucidated by X-ray crystallography and spectroscopic data. (C) 2013 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.

KW - Diterpenes

KW - Hydroxylation

KW - Biotransformation

KW - Labdanolic acid

KW - Fungus

KW - Penicillium janczewskii

U2 - 10.1016/j.phytol.2012.12.005

DO - 10.1016/j.phytol.2012.12.005

M3 - Article

SN - 1874-3900

VL - 6

SP - 165

EP - 169

JO - Phytochemistry Letters

JF - Phytochemistry Letters

IS - 2

ER -