Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients

Jailson F B Querido; María G Echeverría; Gerardo A Marti; Rita Medina Costa; María L Susevich; Jorge E Rabinovich; Aydee Copa; Nair A Montaño; Lineth Garcia; Marisol Cordova; Faustino Torrico; Rubén Sánchez-Eugenia; Lissete Sánchez-Magraner; Xabier Muñiz-Trabudua; Ibai López-Marijuan; Gabriela S Rozas-Dennis; Patricio Diosque; Ana M de Castro; Carlos Robello; Julio S Rodríguez; Jaime Altcheh; Paz M Salazar-Schettino; Marta I Bucio; Bertha Espinoza; Diego M A Guérin; Marcelo Sousa Silva

doi:10.1186/s13071-015-0632-9

Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients

Jailson F B Querido, María G Echeverría, Gerardo A Marti, Rita Medina Costa, María L Susevich, Jorge E Rabinovich, Aydee Copa, Nair A Montaño, Lineth Garcia, Marisol Cordova, Faustino Torrico, Rubén Sánchez-Eugenia, Lissete Sánchez-Magraner, Xabier Muñiz-Trabudua, Ibai López-Marijuan, Gabriela S Rozas-Dennis, Patricio Diosque, Ana M de Castro, Carlos Robello, Julio S RodríguezJaime Altcheh, Paz M Salazar-Schettino, Marta I Bucio, Bertha Espinoza, Diego M A Guérin, Marcelo Sousa Silva

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Abstract

BACKGROUND: Chagas disease is caused by Trypanosoma cruzi, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fecal-oral route and, as it happens with T. cruzi, the infected insects release the virus when defecating during or after blood uptake.

METHODS: In this work, we analysed the occurrence of anti-TrV antibodies in human sera from Chagas disease endemic and non-endemic countries, and developed a mathematical model to estimate the transmission probability of TrV from insects to man, which ranged between 0.00053 and 0.0015.

RESULTS: Our results confirm that people with Chagas disease living in Bolivia, Argentina and Mexico have been exposed to TrV, and that TrV is unable to replicate in human hosts.

CONCLUSIONS: We presented the first experimental evidence of antibodies against TrV structural proteins in human sera.

Original language	English
Pages (from-to)	29
Journal	Parasites & Vectors
Volume	8
DOIs	https://doi.org/10.1186/s13071-015-0632-9
Publication status	Published - 17 Jan 2015

Keywords

Americas
Animals
Antibodies, Viral
Chagas Disease
Dicistroviridae
Enzyme-Linked Immunosorbent Assay
Humans
Models, Biological
Portugal
Seroepidemiologic Studies
Triatoma
Viral Structural Proteins
Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Seroprevalence of Triatoma virusFinal published version, 1.67 MBLicence: CC BY

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Querido, J. F. B., Echeverría, M. G., Marti, G. A., Costa, R. M., Susevich, M. L., Rabinovich, J. E., Copa, A., Montaño, N. A., Garcia, L., Cordova, M., Torrico, F., Sánchez-Eugenia, R., Sánchez-Magraner, L., Muñiz-Trabudua, X., López-Marijuan, I., Rozas-Dennis, G. S., Diosque, P., de Castro, A. M., Robello, C., ... Silva, M. S. (2015). Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients. Parasites & Vectors, 8, 29. https://doi.org/10.1186/s13071-015-0632-9

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title = "Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients",

abstract = "BACKGROUND: Chagas disease is caused by Trypanosoma cruzi, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fecal-oral route and, as it happens with T. cruzi, the infected insects release the virus when defecating during or after blood uptake.METHODS: In this work, we analysed the occurrence of anti-TrV antibodies in human sera from Chagas disease endemic and non-endemic countries, and developed a mathematical model to estimate the transmission probability of TrV from insects to man, which ranged between 0.00053 and 0.0015.RESULTS: Our results confirm that people with Chagas disease living in Bolivia, Argentina and Mexico have been exposed to TrV, and that TrV is unable to replicate in human hosts.CONCLUSIONS: We presented the first experimental evidence of antibodies against TrV structural proteins in human sera.",

keywords = "Americas, Animals, Antibodies, Viral, Chagas Disease, Dicistroviridae, Enzyme-Linked Immunosorbent Assay, Humans, Models, Biological, Portugal, Seroepidemiologic Studies, Triatoma, Viral Structural Proteins, Journal Article, Research Support, Non-U.S. Gov't",

author = "Querido, {Jailson F B} and Echeverr{\'i}a, {Mar{\'i}a G} and Marti, {Gerardo A} and Costa, {Rita Medina} and Susevich, {Mar{\'i}a L} and Rabinovich, {Jorge E} and Aydee Copa and Monta{\~n}o, {Nair A} and Lineth Garcia and Marisol Cordova and Faustino Torrico and Rub{\'e}n S{\'a}nchez-Eugenia and Lissete S{\'a}nchez-Magraner and Xabier Mu{\~n}iz-Trabudua and Ibai L{\'o}pez-Marijuan and Rozas-Dennis, {Gabriela S} and Patricio Diosque and {de Castro}, {Ana M} and Carlos Robello and Rodr{\'i}guez, {Julio S} and Jaime Altcheh and Salazar-Schettino, {Paz M} and Bucio, {Marta I} and Bertha Espinoza and Gu{\'e}rin, {Diego M A} and Silva, {Marcelo Sousa}",

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year = "2015",

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doi = "10.1186/s13071-015-0632-9",

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Querido, JFB, Echeverría, MG, Marti, GA, Costa, RM, Susevich, ML, Rabinovich, JE, Copa, A, Montaño, NA, Garcia, L, Cordova, M, Torrico, F, Sánchez-Eugenia, R, Sánchez-Magraner, L, Muñiz-Trabudua, X, López-Marijuan, I, Rozas-Dennis, GS, Diosque, P, de Castro, AM, Robello, C, Rodríguez, JS, Altcheh, J, Salazar-Schettino, PM, Bucio, MI, Espinoza, B, Guérin, DMA & Silva, MS 2015, 'Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients', Parasites & Vectors, vol. 8, pp. 29. https://doi.org/10.1186/s13071-015-0632-9

TY - JOUR

T1 - Seroprevalence of Triatoma virus (Dicistroviridae

T2 - Cripaviridae) antibodies in Chagas disease patients

AU - Querido, Jailson F B

AU - Echeverría, María G

AU - Marti, Gerardo A

AU - Costa, Rita Medina

AU - Susevich, María L

AU - Rabinovich, Jorge E

AU - Copa, Aydee

AU - Montaño, Nair A

AU - Garcia, Lineth

AU - Cordova, Marisol

AU - Torrico, Faustino

AU - Sánchez-Eugenia, Rubén

AU - Sánchez-Magraner, Lissete

AU - Muñiz-Trabudua, Xabier

AU - López-Marijuan, Ibai

AU - Rozas-Dennis, Gabriela S

AU - Diosque, Patricio

AU - de Castro, Ana M

AU - Robello, Carlos

AU - Rodríguez, Julio S

AU - Altcheh, Jaime

AU - Salazar-Schettino, Paz M

AU - Bucio, Marta I

AU - Espinoza, Bertha

AU - Guérin, Diego M A

AU - Silva, Marcelo Sousa

N1 - PMID: 25595198 WOS:000351038800001

PY - 2015/1/17

Y1 - 2015/1/17

N2 - BACKGROUND: Chagas disease is caused by Trypanosoma cruzi, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fecal-oral route and, as it happens with T. cruzi, the infected insects release the virus when defecating during or after blood uptake.METHODS: In this work, we analysed the occurrence of anti-TrV antibodies in human sera from Chagas disease endemic and non-endemic countries, and developed a mathematical model to estimate the transmission probability of TrV from insects to man, which ranged between 0.00053 and 0.0015.RESULTS: Our results confirm that people with Chagas disease living in Bolivia, Argentina and Mexico have been exposed to TrV, and that TrV is unable to replicate in human hosts.CONCLUSIONS: We presented the first experimental evidence of antibodies against TrV structural proteins in human sera.

AB - BACKGROUND: Chagas disease is caused by Trypanosoma cruzi, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fecal-oral route and, as it happens with T. cruzi, the infected insects release the virus when defecating during or after blood uptake.METHODS: In this work, we analysed the occurrence of anti-TrV antibodies in human sera from Chagas disease endemic and non-endemic countries, and developed a mathematical model to estimate the transmission probability of TrV from insects to man, which ranged between 0.00053 and 0.0015.RESULTS: Our results confirm that people with Chagas disease living in Bolivia, Argentina and Mexico have been exposed to TrV, and that TrV is unable to replicate in human hosts.CONCLUSIONS: We presented the first experimental evidence of antibodies against TrV structural proteins in human sera.

KW - Americas

KW - Animals

KW - Antibodies, Viral

KW - Chagas Disease

KW - Dicistroviridae

KW - Enzyme-Linked Immunosorbent Assay

KW - Humans

KW - Models, Biological

KW - Portugal

KW - Seroepidemiologic Studies

KW - Triatoma

KW - Viral Structural Proteins

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1186/s13071-015-0632-9

DO - 10.1186/s13071-015-0632-9

M3 - Article

C2 - 25595198

VL - 8

SP - 29

JO - Parasites & Vectors

JF - Parasites & Vectors

ER -

Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients

Abstract

Keywords

UN SDGs

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