Seroprevalence of Triatoma virus (Dicistroviridae

Cripaviridae) antibodies in Chagas disease patients

Jailson F B Querido, María G Echeverría, Gerardo A Marti, Rita Medina Costa, María L Susevich, Jorge E Rabinovich, Aydee Copa, Nair A Montaño, Lineth Garcia, Marisol Cordova, Faustino Torrico, Rubén Sánchez-Eugenia, Lissete Sánchez-Magraner, Xabier Muñiz-Trabudua, Ibai López-Marijuan, Gabriela S Rozas-Dennis, Patricio Diosque, Ana M de Castro, Carlos Robello, Julio S Rodríguez & 6 others Jaime Altcheh, Paz M Salazar-Schettino, Marta I Bucio, Bertha Espinoza, Diego M A Guérin, Marcelo Sousa Silva

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Chagas disease is caused by Trypanosoma cruzi, and humans acquire the parasite by exposure to contaminated feces from hematophagous insect vectors known as triatomines. Triatoma virus (TrV) is the sole viral pathogen of triatomines, and is transmitted among insects through the fecal-oral route and, as it happens with T. cruzi, the infected insects release the virus when defecating during or after blood uptake.

METHODS: In this work, we analysed the occurrence of anti-TrV antibodies in human sera from Chagas disease endemic and non-endemic countries, and developed a mathematical model to estimate the transmission probability of TrV from insects to man, which ranged between 0.00053 and 0.0015.

RESULTS: Our results confirm that people with Chagas disease living in Bolivia, Argentina and Mexico have been exposed to TrV, and that TrV is unable to replicate in human hosts.

CONCLUSIONS: We presented the first experimental evidence of antibodies against TrV structural proteins in human sera.

Original languageEnglish
Pages (from-to)29
JournalParasites & Vectors
Volume8
DOIs
Publication statusPublished - 17 Jan 2015

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Keywords

  • Americas
  • Animals
  • Antibodies, Viral
  • Chagas Disease
  • Dicistroviridae
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Models, Biological
  • Portugal
  • Seroepidemiologic Studies
  • Triatoma
  • Viral Structural Proteins
  • Journal Article
  • Research Support, Non-U.S. Gov't

Cite this

Querido, J. F. B., Echeverría, M. G., Marti, G. A., Costa, R. M., Susevich, M. L., Rabinovich, J. E., ... Silva, M. S. (2015). Seroprevalence of Triatoma virus (Dicistroviridae: Cripaviridae) antibodies in Chagas disease patients. Parasites & Vectors, 8, 29. https://doi.org/10.1186/s13071-015-0632-9