Sensitization of 5-bromouridine by slow electrons

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Abstract

Substitution of thymidine by 5-bromouridine within DNA sensitizes the nucleic acid to radiation. We show here the ability of low-energy (<12 eV) electrons, abundantly produced along the ionization tracks, to effectively decompose the radiosensitizer via two main fragmentation channels to produce the bromine anion and the 5-bromouracil-yl anion, with a cross-section of 2×-10 -14 and 9×10 -16 cm 2, respectively. The formation of these negative fragments is accompanied by their corresponding reactive radicals, i.e., uracil-yl radical bound to the sugar moiety and 2-deoxyribose-yl radical, which are both considered as precursors for DNA strand breaks. © 2004 Elsevier B.V.
Original languageEnglish
Pages (from-to)442-447
Number of pages6
JournalChemical Physics Letters
Volume393
Issue number4-6
DOIs
Publication statusPublished - 1 Aug 2004

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Keywords

  • uridine derivative
  • 5 bromouridine
  • bromine derivative
  • DNA
  • radical
  • thymidine
  • unclassified drug
  • uracil

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