@article{39de54821f154d3cafb45c3f2356f45a,
title = "Sample treatment for protein identification by mass spectrometry-based techniques",
abstract = "Rapid identification of proteins is of primary importance for the analytical community. Protein-biomarker discovery for medical diagnostics or pharmacological purposes is becoming one of the hottest research topics. Moreover, rapid identification of proteins can help unambiguous bacterial and virus detection. In addition, the fast identification of bacteria can be used to beat bioterrorism. As a consequence, new analytical methodologies have emerged recently with the aim of making protein analysis as fast and as confident as possible. In this article, we critically review the new trends in sample treatment for protein identification and comment on the prospects for the future in this promising analytical area.",
keywords = "Biomarker, Protein, Rapid identification, Sample treatment",
author = "D. L{\'o}pez-Ferrer and B. Ca{\~n}as and J. V{\'a}zquez and C. Lodeiro and R. Rial-Otero and I. Moura and Capelo, {J. L.}",
note = "We thank Antonio Ramos-Fern{\'a}ndez for helpful advice and discussion. This work was supported by grants CICYT BIO2003-01805 and CAM 08.5/0065.1/2001 and by an institutional grant by Fundaci{\'o}n Ramon Areces to CBMSO. R. Rial-Otero acknowledges the post-doctoral grant SFRH/BPD/23072/2005 from FCT (Science and Technical Foundation), Portugal. Financial support by FCT and FEDER under Projects POCI/QUI/55519/2004 and MetalControl N-1734 is also acknowledged. J.L. Capelo acknowledges the MALDI-TOF-MS Service of the Chemistry Department of the New University of Lisbon ( http://www.dq.fct.unl.pt/eggebap/ ) for helpful assistance and valuable suggestions. The research findings reported are protected by international laws under patent request PORT No. 23848 of the INI, Instituto Nacional da Propiedade Industrial, Portugal.",
year = "2006",
month = nov,
day = "1",
doi = "10.1016/j.trac.2006.05.015",
language = "English",
volume = "25",
pages = "996--1005",
journal = "TrAC - Trends in Analytical Chemistry",
issn = "0165-9936",
publisher = "Elsevier Science B.V., Amsterdam.",
number = "10",
}