Role of the siderophore transporter SirABC in the Staphylococcus aureus resistance to oxidative stress

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In Staphylococcus aureus, the intracellular siderophore staphyloferrin B, which has been shown to chelate iron-bound to serum transferrin, is transported into cells by the SirABC system. In this work, we have analysed the role of the Sir transporter under stress conditions that resemble those imposed by the mammalian innate immune system. We show that exposure of S. aureus to oxidative and nitrosative stress generated by hydrogen peroxide and S-nitrosoglutathione, respectively, induced the expression of the sirA gene. The disruption of the sir operon led to a strain with lower viability and decreased resistance to oxidative stress. S. aureus sir null mutant was also analysed during infection of murine macrophages and shown to contribute to S. aureus survival inside macrophages. Altogether, our results indicate that the Sir transport system confers protection against reactive oxygen species, therefore, contributing to the virulence of S. aureus.

Original languageEnglish
Pages (from-to)164-168
Number of pages5
JournalCurrent Microbiology
Volume69
Issue number2
DOIs
Publication statusPublished - 2014

Fingerprint Dive into the research topics of 'Role of the siderophore transporter SirABC in the Staphylococcus aureus resistance to oxidative stress'. Together they form a unique fingerprint.

Cite this