8 Citations (Scopus)

Abstract

Ingestion of a meal is the greatest challenge faced by glucose homeostasis. The surge of nutrients has to be disposed quickly, as high concentrations in the bloodstream may have pathophysiological effects, and also properly, as misplaced reserves may induce problems in affected tissues. Thus, loss of the ability to adequately dispose of ingested nutrients can be expected to lead to glucose intolerance, and favor the development of pathologies. Achieving interplay of several organs is of upmost importance to maintain effectively postprandial glucose clearance, with the liver being responsible of orchestrating global glycemic control. This dogmatic role of the liver in postprandial insulin sensitivity is tightly associated with the vagus nerve. Herein, we uncover the behaviour of metabolic pathways determined by hepatic parasympathetic function status, in physiology and in pathophysiology. Likewise, the inquiry expands to address the impact of a modern lifestyle, especially one's feeding habits, on the hepatic parasympathetic nerve control of glucose metabolism.
Original languageEnglish
Pages (from-to)67-77
Number of pages11
JournalReviews In Endocrine & Metabolic Disorders
Volume15
Issue number1
DOIs
Publication statusPublished - 2013

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Insulin Resistance
Liver
Glucose
Food
Aptitude
Vagus Nerve
Glucose Intolerance
Metabolic Networks and Pathways
Habits
Meals
Life Style
Homeostasis
Eating
Pathology

Cite this

@article{ca71cecf68284f32942b290485db7970,
title = "Risk of postprandial insulin resistance: The liver/vagus rapport.",
abstract = "Ingestion of a meal is the greatest challenge faced by glucose homeostasis. The surge of nutrients has to be disposed quickly, as high concentrations in the bloodstream may have pathophysiological effects, and also properly, as misplaced reserves may induce problems in affected tissues. Thus, loss of the ability to adequately dispose of ingested nutrients can be expected to lead to glucose intolerance, and favor the development of pathologies. Achieving interplay of several organs is of upmost importance to maintain effectively postprandial glucose clearance, with the liver being responsible of orchestrating global glycemic control. This dogmatic role of the liver in postprandial insulin sensitivity is tightly associated with the vagus nerve. Herein, we uncover the behaviour of metabolic pathways determined by hepatic parasympathetic function status, in physiology and in pathophysiology. Likewise, the inquiry expands to address the impact of a modern lifestyle, especially one's feeding habits, on the hepatic parasympathetic nerve control of glucose metabolism.",
keywords = "GLUTATHIONE SYNTHESIS, AUTONOMIC NERVOUS-SYSTEM, S-NITROSOTHIOLS, NITRIC-OXIDE, Glutathione, TYPE-2 DIABETES-MELLITUS, Postprandial insulin resistance, POWER SPECTRAL-ANALYSIS, SKELETAL-MUSCLE, Nitric oxide, Glucose intolerance, IMPROVES GLUCOSE-TOLERANCE, Liver, VAGUS NERVE, Vagus, OXIDATIVE STRESS",
author = "Macedo, {Maria P} and Afonso, {Ricardo A.} and Rita Patarr{\~a}o and Lima, {In{\^e}s Sousa} and Gaspar, {Joana M.} and Ribeiro, {Rog{\'e}rio T.}",
year = "2013",
doi = "10.1007/s11154-013-9281-5",
language = "English",
volume = "15",
pages = "67--77",
journal = "Reviews In Endocrine & Metabolic Disorders",
issn = "1389-9155",
publisher = "Springer Science Business Media",
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TY - JOUR

T1 - Risk of postprandial insulin resistance: The liver/vagus rapport.

AU - Macedo, Maria P

AU - Afonso, Ricardo A.

AU - Patarrão, Rita

AU - Lima, Inês Sousa

AU - Gaspar, Joana M.

AU - Ribeiro, Rogério T.

PY - 2013

Y1 - 2013

N2 - Ingestion of a meal is the greatest challenge faced by glucose homeostasis. The surge of nutrients has to be disposed quickly, as high concentrations in the bloodstream may have pathophysiological effects, and also properly, as misplaced reserves may induce problems in affected tissues. Thus, loss of the ability to adequately dispose of ingested nutrients can be expected to lead to glucose intolerance, and favor the development of pathologies. Achieving interplay of several organs is of upmost importance to maintain effectively postprandial glucose clearance, with the liver being responsible of orchestrating global glycemic control. This dogmatic role of the liver in postprandial insulin sensitivity is tightly associated with the vagus nerve. Herein, we uncover the behaviour of metabolic pathways determined by hepatic parasympathetic function status, in physiology and in pathophysiology. Likewise, the inquiry expands to address the impact of a modern lifestyle, especially one's feeding habits, on the hepatic parasympathetic nerve control of glucose metabolism.

AB - Ingestion of a meal is the greatest challenge faced by glucose homeostasis. The surge of nutrients has to be disposed quickly, as high concentrations in the bloodstream may have pathophysiological effects, and also properly, as misplaced reserves may induce problems in affected tissues. Thus, loss of the ability to adequately dispose of ingested nutrients can be expected to lead to glucose intolerance, and favor the development of pathologies. Achieving interplay of several organs is of upmost importance to maintain effectively postprandial glucose clearance, with the liver being responsible of orchestrating global glycemic control. This dogmatic role of the liver in postprandial insulin sensitivity is tightly associated with the vagus nerve. Herein, we uncover the behaviour of metabolic pathways determined by hepatic parasympathetic function status, in physiology and in pathophysiology. Likewise, the inquiry expands to address the impact of a modern lifestyle, especially one's feeding habits, on the hepatic parasympathetic nerve control of glucose metabolism.

KW - GLUTATHIONE SYNTHESIS

KW - AUTONOMIC NERVOUS-SYSTEM

KW - S-NITROSOTHIOLS

KW - NITRIC-OXIDE

KW - Glutathione

KW - TYPE-2 DIABETES-MELLITUS

KW - Postprandial insulin resistance

KW - POWER SPECTRAL-ANALYSIS

KW - SKELETAL-MUSCLE

KW - Nitric oxide

KW - Glucose intolerance

KW - IMPROVES GLUCOSE-TOLERANCE

KW - Liver

KW - VAGUS NERVE

KW - Vagus

KW - OXIDATIVE STRESS

U2 - 10.1007/s11154-013-9281-5

DO - 10.1007/s11154-013-9281-5

M3 - Article

VL - 15

SP - 67

EP - 77

JO - Reviews In Endocrine & Metabolic Disorders

JF - Reviews In Endocrine & Metabolic Disorders

SN - 1389-9155

IS - 1

ER -