TY - JOUR
T1 - RISCOP–Cognitive profile in a Portuguese cohort of radiological isolated syndrome patients
T2 - A case-control study
AU - Carvalho, Vanessa
AU - Soares, Carolina
AU - Gomes, Inês
AU - Carvalho, Andreia
AU - Serrazina, Filipa
AU - Rodrigues, Sofia Grenho
AU - Pinheiro, Joaquim
AU - Marques, Inês Brás
AU - Correia, Filipe
AU - Correia, Ana Sofia
AU - de Sá, João
AU - Sousa, Lívia
AU - Vale, José
AU - Sá, Maria José
AU - Sousa, Cláudia
AU - Ferreira, João
PY - 2021/5
Y1 - 2021/5
N2 - Introduction: Radiologically isolated syndrome (RIS) refers to the incidental discovery of white matter lesions suggestive of MS, on brain MRI, in asymptomatic patients. Recent studies suggest similar features of cognitive impairment between RIS and MS patients. Also, lower levels of health-related quality of life (QOL) and fatigue are reported in such patients. Aims: characterize and compare the cognitive profile of a multicentric Portuguese cohort of RIS patients with a control group. Methods: multicentric comparative study of a cohort of adult patients with RIS, and age and gender-matched controls followed in the headache outpatient clinic with prior MRI not fulfilling criteria for RIS diagnosis. We conducted interviews with participants, collected clinical data and applied the BICAMS battery and self-reported questionnaires (HADS, MFIS, MSQOL-54). Results: we evaluated 31 patients with RIS (median age 46 years, IQR [(Dusankova et al., 2012-52], 72% women) and 19 control individuals (median age 32 years, IQR [(O'Jile et al., 2005-48], 71% women). Prevalence of cognitive impairment did not differ between groups (16% of the RIS and 10% of the controls, p=0.579). We found no differences between groups on the BICAMS tests, although the results of the California Verbal Learning Test (CVLT-II) score presented a trend to significance, with a lower value on the RIS group (53.9 vs. 59.3, p=0.066). There were no significant differences regarding fatigue, QOL, anxiety/depression scores. Conclusion: this is the first study on a Portuguese cohort of RIS patients assessing cognitive profile with BICAMS. A non-neglectable part of our cohort presented cognitive impairment. Our findings add to previous studies in suggesting that a more pronounced impairment of verbal memory and learning, evaluated by CVLT-II, may be present in RIS patients compared to controls. BICAMS should be assessed on future studies with larger cohorts.
AB - Introduction: Radiologically isolated syndrome (RIS) refers to the incidental discovery of white matter lesions suggestive of MS, on brain MRI, in asymptomatic patients. Recent studies suggest similar features of cognitive impairment between RIS and MS patients. Also, lower levels of health-related quality of life (QOL) and fatigue are reported in such patients. Aims: characterize and compare the cognitive profile of a multicentric Portuguese cohort of RIS patients with a control group. Methods: multicentric comparative study of a cohort of adult patients with RIS, and age and gender-matched controls followed in the headache outpatient clinic with prior MRI not fulfilling criteria for RIS diagnosis. We conducted interviews with participants, collected clinical data and applied the BICAMS battery and self-reported questionnaires (HADS, MFIS, MSQOL-54). Results: we evaluated 31 patients with RIS (median age 46 years, IQR [(Dusankova et al., 2012-52], 72% women) and 19 control individuals (median age 32 years, IQR [(O'Jile et al., 2005-48], 71% women). Prevalence of cognitive impairment did not differ between groups (16% of the RIS and 10% of the controls, p=0.579). We found no differences between groups on the BICAMS tests, although the results of the California Verbal Learning Test (CVLT-II) score presented a trend to significance, with a lower value on the RIS group (53.9 vs. 59.3, p=0.066). There were no significant differences regarding fatigue, QOL, anxiety/depression scores. Conclusion: this is the first study on a Portuguese cohort of RIS patients assessing cognitive profile with BICAMS. A non-neglectable part of our cohort presented cognitive impairment. Our findings add to previous studies in suggesting that a more pronounced impairment of verbal memory and learning, evaluated by CVLT-II, may be present in RIS patients compared to controls. BICAMS should be assessed on future studies with larger cohorts.
KW - BICAMS
KW - Cognition
KW - Learning
KW - Radiological isolated syndrome
KW - Verbal memory
UR - http://www.scopus.com/inward/record.url?scp=85100704471&partnerID=8YFLogxK
U2 - 10.1016/j.msard.2021.102832
DO - 10.1016/j.msard.2021.102832
M3 - Article
C2 - 33596492
AN - SCOPUS:85100704471
VL - 50
JO - MULTIPLE SCLEROSIS AND RELATED DISORDERS
JF - MULTIPLE SCLEROSIS AND RELATED DISORDERS
SN - 2211-0348
M1 - 102832
ER -