Abstract
The Rho kinase (ROCK) signaling pathway is involved in several cellular events that include cell proliferation and cytoskeleton modulation leading to cell adhesion. The ROCK pathway in the human eye has been hypothesized to play important roles in corneal endothelial cell physiology and pathologic states. In addition, ROCK signaling has been identified as an important regulator of trabecular meshwork (TM) outflow, which is altered in glaucomatous eyes. These roles in corneal and glaucomatous disease states have led to the growing interest in the development of drugs selectively targeting this pathway (ROCK inhibitors). The authors provide a review of the literature on the pathobiology of the ROCK signaling in corneal endothelial disease, glaucoma, and vitreoretinal disease, as well as the clinical usefulness of ROCK inhibitors in Ophthalmology.
| Original language | English |
|---|---|
| Pages (from-to) | 1101-1117 |
| Journal | Graefe's Archive for Clinical and Experimental Ophthalmology |
| Volume | 257 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Mar 2019 |
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Keywords
- Corneal endothelial disease
- Glaucoma
- Rho kinase
- Rho kinase inhibitors
- Vitreoretinal disease
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Rho kinase inhibitors—a review on the physiology and clinical use in Ophthalmology. / Moura-Coelho, Nuno; Tavares Ferreira, Joana; Bruxelas, Carolina Pereira; Dutra-Medeiros, Marco; Cunha, João Paulo; Pinto Proença, Rita.
In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 257, No. 6, 03.2019, p. 1101-1117.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Rho kinase inhibitors—a review on the physiology and clinical use in Ophthalmology
AU - Moura-Coelho, Nuno
AU - Tavares Ferreira, Joana
AU - Bruxelas, Carolina Pereira
AU - Dutra-Medeiros, Marco
AU - Cunha, João Paulo
AU - Pinto Proença, Rita
PY - 2019/3
Y1 - 2019/3
N2 - The Rho kinase (ROCK) signaling pathway is involved in several cellular events that include cell proliferation and cytoskeleton modulation leading to cell adhesion. The ROCK pathway in the human eye has been hypothesized to play important roles in corneal endothelial cell physiology and pathologic states. In addition, ROCK signaling has been identified as an important regulator of trabecular meshwork (TM) outflow, which is altered in glaucomatous eyes. These roles in corneal and glaucomatous disease states have led to the growing interest in the development of drugs selectively targeting this pathway (ROCK inhibitors). The authors provide a review of the literature on the pathobiology of the ROCK signaling in corneal endothelial disease, glaucoma, and vitreoretinal disease, as well as the clinical usefulness of ROCK inhibitors in Ophthalmology.
AB - The Rho kinase (ROCK) signaling pathway is involved in several cellular events that include cell proliferation and cytoskeleton modulation leading to cell adhesion. The ROCK pathway in the human eye has been hypothesized to play important roles in corneal endothelial cell physiology and pathologic states. In addition, ROCK signaling has been identified as an important regulator of trabecular meshwork (TM) outflow, which is altered in glaucomatous eyes. These roles in corneal and glaucomatous disease states have led to the growing interest in the development of drugs selectively targeting this pathway (ROCK inhibitors). The authors provide a review of the literature on the pathobiology of the ROCK signaling in corneal endothelial disease, glaucoma, and vitreoretinal disease, as well as the clinical usefulness of ROCK inhibitors in Ophthalmology.
KW - Corneal endothelial disease
KW - Glaucoma
KW - Rho kinase
KW - Rho kinase inhibitors
KW - Vitreoretinal disease
UR - http://www.scopus.com/inward/record.url?scp=85062688043&partnerID=8YFLogxK
U2 - 10.1007/s00417-019-04283-5
DO - 10.1007/s00417-019-04283-5
M3 - Review article
VL - 257
SP - 1101
EP - 1117
JO - Graefe's Archive for Clinical and Experimental Ophthalmology
JF - Graefe's Archive for Clinical and Experimental Ophthalmology
SN - 0721-832X
IS - 6
ER -