Rho kinase inhibitors—a review on the physiology and clinical use in Ophthalmology

Nuno Moura-Coelho, Joana Tavares Ferreira, Carolina Pereira Bruxelas, Marco Dutra-Medeiros, João Paulo Cunha, Rita Pinto Proença

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

The Rho kinase (ROCK) signaling pathway is involved in several cellular events that include cell proliferation and cytoskeleton modulation leading to cell adhesion. The ROCK pathway in the human eye has been hypothesized to play important roles in corneal endothelial cell physiology and pathologic states. In addition, ROCK signaling has been identified as an important regulator of trabecular meshwork (TM) outflow, which is altered in glaucomatous eyes. These roles in corneal and glaucomatous disease states have led to the growing interest in the development of drugs selectively targeting this pathway (ROCK inhibitors). The authors provide a review of the literature on the pathobiology of the ROCK signaling in corneal endothelial disease, glaucoma, and vitreoretinal disease, as well as the clinical usefulness of ROCK inhibitors in Ophthalmology.

Original languageEnglish
Pages (from-to)1101-1117
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume257
Issue number6
DOIs
Publication statusPublished - Mar 2019

Keywords

  • Corneal endothelial disease
  • Glaucoma
  • Rho kinase
  • Rho kinase inhibitors
  • Vitreoretinal disease

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