Preferential Rh(II) carbenoid intramolecular C-H versus O-H insertion derived from α-diazo-acetamides can be achieved in water by using an appropriate combination of the catalyst and amide groups, which creates a larger hydrophobic environment around the reactive carbenoid center.
|Number of pages||9|
|Journal||Journal of Organic Chemistry|
|Publication status||Published - 21 Jul 2006|
- Nitrogen compounds
- Molecular dynamics