TY - JOUR
T1 - Responses of Clostridia to oxygen
T2 - from detoxification to adaptive strategies
AU - Morvan, Claire
AU - Folgosa, Filipe
AU - Kint, Nicolas
AU - Teixeira, Miguel
AU - Martin-Verstraete, Isabelle
N1 - Funding Information:
We are thankful to Sandrine Auger and Carolina Alves‐Feliciano for their helpful discussions. Part of the work described in this review was supported by grants from the Portuguese Funcação para a Ciência e Tecnologia (FCT), PTDC/BIA‐BQM/27959/2017 and PTDC/BIA‐BQM/0562/2020 and by ITQB MOSTMICRO (UIDB/04612/2020 and UIDP/04612/2020) Research Unit, co‐funded by FCT, through National funds, and by FEDER under the PT2020 Partnership Agreement. This work has also received funding from the European Union's Horizon 2020 research and innovation program under grant agreement 810856. The work described in this review was funded by Institut Pasteur, the Université de Paris and the ITN Marie Curie, Clospore (H2020‐MSCA‐ITN‐2014 642068). N.K. was a postdoctoral fellow from Université de Paris.
Funding Information:
We are thankful to Sandrine Auger and Carolina Alves-Feliciano for their helpful discussions. Part of the work described in this review was supported by grants from the Portuguese Funca??o para a Ci?ncia e Tecnologia (FCT), PTDC/BIA-BQM/27959/2017 and PTDC/BIA-BQM/0562/2020 and by ITQB MOSTMICRO (UIDB/04612/2020 and UIDP/04612/2020) Research Unit, co-funded by FCT, through National funds, and by FEDER under the PT2020 Partnership Agreement. This work has also received funding from the European Union's Horizon 2020 research and innovation program under grant agreement 810856. The work described in this review was funded by Institut Pasteur, the Universit? de Paris and the ITN Marie Curie, Clospore (H2020-MSCA-ITN-2014 642068). N.K. was a postdoctoral fellow from Universit? de Paris.
Publisher Copyright:
© 2021 Society for Applied Microbiology and John Wiley & Sons Ltd.
PY - 2021/8
Y1 - 2021/8
N2 - Clostridia comprise bacteria of environmental, biotechnological and medical interest and many commensals of the gut microbiota. Because of their strictly anaerobic lifestyle, oxygen is a major stress for Clostridia. However, recent data showed that these bacteria can cope with O2 better than expected for obligate anaerobes through their ability to scavenge, detoxify and consume O2. Upon O2 exposure, Clostridia redirect their central metabolism onto pathways less O2-sensitive and induce the expression of genes encoding enzymes involved in O2-reduction and in the repair of oxidized damaged molecules. While Faecalibacterium prausnitzii efficiently consumes O2 through a specific extracellular electron shuttling system requiring riboflavin, enzymes such as rubrerythrins and flavodiiron proteins with NAD(P)H-dependent O2- and/or H2O2-reductase activities are usually encoded in other Clostridia. These two classes of enzymes play indeed a pivotal role in O2 tolerance in Clostridioides difficile and Clostridium acetobutylicum. Two main signalling pathways triggering O2-induced responses have been described so far in Clostridia. PerR acts as a key regulator of the O2- and/or reactive oxygen species–defence machinery while in C. difficile, σB, the sigma factor of the general stress response also plays a crucial role in O2 tolerance by controlling the expression of genes involved in O2 scavenging and repair systems.
AB - Clostridia comprise bacteria of environmental, biotechnological and medical interest and many commensals of the gut microbiota. Because of their strictly anaerobic lifestyle, oxygen is a major stress for Clostridia. However, recent data showed that these bacteria can cope with O2 better than expected for obligate anaerobes through their ability to scavenge, detoxify and consume O2. Upon O2 exposure, Clostridia redirect their central metabolism onto pathways less O2-sensitive and induce the expression of genes encoding enzymes involved in O2-reduction and in the repair of oxidized damaged molecules. While Faecalibacterium prausnitzii efficiently consumes O2 through a specific extracellular electron shuttling system requiring riboflavin, enzymes such as rubrerythrins and flavodiiron proteins with NAD(P)H-dependent O2- and/or H2O2-reductase activities are usually encoded in other Clostridia. These two classes of enzymes play indeed a pivotal role in O2 tolerance in Clostridioides difficile and Clostridium acetobutylicum. Two main signalling pathways triggering O2-induced responses have been described so far in Clostridia. PerR acts as a key regulator of the O2- and/or reactive oxygen species–defence machinery while in C. difficile, σB, the sigma factor of the general stress response also plays a crucial role in O2 tolerance by controlling the expression of genes involved in O2 scavenging and repair systems.
UR - http://www.scopus.com/inward/record.url?scp=85110286813&partnerID=8YFLogxK
U2 - 10.1111/1462-2920.15665
DO - 10.1111/1462-2920.15665
M3 - Review article
C2 - 34245087
AN - SCOPUS:85110286813
SN - 1462-2912
VL - 23
SP - 4112
EP - 4125
JO - Environmental Microbiology
JF - Environmental Microbiology
IS - 8
ER -