Response of the pulmonary circulation to acute hypoxia in the growing pig

A. Rendas, M. Branthwaite, S. Lennox, L. Reid

Research output: Contribution to journalArticle

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Abstract

In a previous article we have analyzed the structure of the growing pig lung and correlated the findings with cardiorespiratory function studies on the same animals (J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 45: 806-817, 1978). The present study analyzes the pulmonary and systemic vascular responses to acute hypoxia in some of those animals at three ages, 2-4, 5-8, and 9-12 wk, the lung of the 12-wk-old pig being structurally similar to that of the adult. In all anesthetized animals, acute hypoxia (5 min 10% fractional inspired oxygen concentration) increased mean pulmonary arterial pressure (P̄pa) and total pulmonary resistance (TPR). The increase over base line of P̄pa was 41.3% in animals aged 2-4 wk, 83% in those aged 5-8 wk, and 136.9% in those aged 9-12 wk; for TPR the increase in the three age groups was 66.4, 92.4, and 138.9%, respectively. This difference in vasoactivity with age is associated with the progressive extension of smooth muscle into the intra-acinar arterial tree, which we have previously shown is an important feature of the structural remodeling that occurs during postnatal lung development in both man and swine.

Original languageEnglish
Pages (from-to)811-814
Number of pages4
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume52
Issue number4
Publication statusPublished - 1 Jan 1982

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Pulmonary Circulation
Swine
Lung
Hypoxia
Smooth Muscle
Blood Vessels
Arterial Pressure
Age Groups
Exercise
Oxygen

Cite this

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Response of the pulmonary circulation to acute hypoxia in the growing pig. / Rendas, A.; Branthwaite, M.; Lennox, S.; Reid, L.

In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, Vol. 52, No. 4, 01.01.1982, p. 811-814.

Research output: Contribution to journalArticle

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