Abstract
In a previous article we have analyzed the structure of the growing pig lung and correlated the findings with cardiorespiratory function studies on the same animals (J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 45: 806-817, 1978). The present study analyzes the pulmonary and systemic vascular responses to acute hypoxia in some of those animals at three ages, 2-4, 5-8, and 9-12 wk, the lung of the 12-wk-old pig being structurally similar to that of the adult. In all anesthetized animals, acute hypoxia (5 min 10% fractional inspired oxygen concentration) increased mean pulmonary arterial pressure (P̄pa) and total pulmonary resistance (TPR). The increase over base line of P̄pa was 41.3% in animals aged 2-4 wk, 83% in those aged 5-8 wk, and 136.9% in those aged 9-12 wk; for TPR the increase in the three age groups was 66.4, 92.4, and 138.9%, respectively. This difference in vasoactivity with age is associated with the progressive extension of smooth muscle into the intra-acinar arterial tree, which we have previously shown is an important feature of the structural remodeling that occurs during postnatal lung development in both man and swine.
| Original language | English |
|---|---|
| Pages (from-to) | 811-814 |
| Number of pages | 4 |
| Journal | Journal of Applied Physiology Respiratory Environmental and Exercise Physiology |
| Volume | 52 |
| Issue number | 4 |
| Publication status | Published - 1 Jan 1982 |
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Response of the pulmonary circulation to acute hypoxia in the growing pig. / Rendas, A.; Branthwaite, M.; Lennox, S.; Reid, L.
In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, Vol. 52, No. 4, 01.01.1982, p. 811-814.Research output: Contribution to journal › Article
TY - JOUR
T1 - Response of the pulmonary circulation to acute hypoxia in the growing pig
AU - Rendas, A.
AU - Branthwaite, M.
AU - Lennox, S.
AU - Reid, L.
PY - 1982/1/1
Y1 - 1982/1/1
N2 - In a previous article we have analyzed the structure of the growing pig lung and correlated the findings with cardiorespiratory function studies on the same animals (J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 45: 806-817, 1978). The present study analyzes the pulmonary and systemic vascular responses to acute hypoxia in some of those animals at three ages, 2-4, 5-8, and 9-12 wk, the lung of the 12-wk-old pig being structurally similar to that of the adult. In all anesthetized animals, acute hypoxia (5 min 10% fractional inspired oxygen concentration) increased mean pulmonary arterial pressure (P̄pa) and total pulmonary resistance (TPR). The increase over base line of P̄pa was 41.3% in animals aged 2-4 wk, 83% in those aged 5-8 wk, and 136.9% in those aged 9-12 wk; for TPR the increase in the three age groups was 66.4, 92.4, and 138.9%, respectively. This difference in vasoactivity with age is associated with the progressive extension of smooth muscle into the intra-acinar arterial tree, which we have previously shown is an important feature of the structural remodeling that occurs during postnatal lung development in both man and swine.
AB - In a previous article we have analyzed the structure of the growing pig lung and correlated the findings with cardiorespiratory function studies on the same animals (J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 45: 806-817, 1978). The present study analyzes the pulmonary and systemic vascular responses to acute hypoxia in some of those animals at three ages, 2-4, 5-8, and 9-12 wk, the lung of the 12-wk-old pig being structurally similar to that of the adult. In all anesthetized animals, acute hypoxia (5 min 10% fractional inspired oxygen concentration) increased mean pulmonary arterial pressure (P̄pa) and total pulmonary resistance (TPR). The increase over base line of P̄pa was 41.3% in animals aged 2-4 wk, 83% in those aged 5-8 wk, and 136.9% in those aged 9-12 wk; for TPR the increase in the three age groups was 66.4, 92.4, and 138.9%, respectively. This difference in vasoactivity with age is associated with the progressive extension of smooth muscle into the intra-acinar arterial tree, which we have previously shown is an important feature of the structural remodeling that occurs during postnatal lung development in both man and swine.
UR - http://www.scopus.com/inward/record.url?scp=0019962657&partnerID=8YFLogxK
M3 - Article
VL - 52
SP - 811
EP - 814
JO - Journal of Applied Physiology Respiratory Environmental and Exercise Physiology
JF - Journal of Applied Physiology Respiratory Environmental and Exercise Physiology
SN - 0161-7567
IS - 4
ER -