Respiratory microbiota and lower respiratory tract disease

Miguel Lanaspa, Quique Bassat, Marcia Melo Medeiros, Camen Muñoz-Almagro

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)


Introduction: The respiratory airways harbor a complex succession of ecological niches with distinct but related bacterial communities. Particular challenges of respiratory microbiome research have led to limited scientific output compared to other human microbiomes. Areas covered: In this review, we summarize the current state of knowledge of the bacterial respiratory microbiome, with a particular focus on associations between the respiratory microbiome and lower respiratory tract conditions. Expert commentary: There is growing evidence that the respiratory microbiome is associated with lower respiratory infectious diseases and related conditions. Most respiratory microbiome reports are metataxonomic cross-sectional or case-control studies with relatively small sample sizes. Large, prospective projects with metatranscriptomics or metabolomics approach are needed to unravel the effect of the respiratory microbiome on health-related conditions. Moreover, standardization in sampling, library preparation, sequencing techniques and data analysis should be encouraged.

Original languageEnglish
Pages (from-to)703-711
Number of pages9
JournalExpert Review of Anti-Infective Therapy
Issue number7
Publication statusPublished - 3 Jul 2017


  • 16S rRNA
  • Asthma
  • Bronchiolitis
  • Lower respiratory tract infections
  • Next-generation sequencing
  • Pneumonia
  • Respiratory microbiome


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