Respiratory infections in elderly people

viral role in a resident population of elderly care centers in Lisbon, winter 2013-2014

Maria-Jesus Chasqueira, Paulo Paixão, Maria-Lúcia Rodrigues, Cátia Piedade, Iolanda Caires, Teresa Palmeiro, Maria-Amalia Botelho, Madalena Santos, Martin Curran, Raquel Guiomar, Pedro Pechirra, Inês Costa, Ana Papoila, Marta Alves, Nuno Neuparth

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Abstract

OBJECTIVE: the aim of this study was to analyze the etiology and clinical consequences of viral respiratory infections in 18 elderly care centers (ECC) in Lisbon, which housed a total of 1022 residents.

METHODS: nasopharyngeal swabs were collected whenever an elderly had symptoms of acute respiratory infections (ARI). PCR and RT-PCR were performed for influenza A/B, human parainfluenza virus 1-4, adenovirus, human metapneumovirus (HMPV), respiratory syncytial virus (RSV), rhinovirus, enterovirus, human coronavirus and human Bocavirus (HBoV). Array cards for atypical bacteria were also used in severe cases.

RESULTS: in total, 188 episodes of ARI were reported, being rhinovirus the most frequently detected (n=53), followed by influenza A(H3) (n=19) and HBoV (n=14). Severe infections were reported in 19 patients, 11 of which were fatal, Legionela pneumophila, rhinovirus, HMPV and RSV associated with these fatalities. Nine influenza strains were analyzed, all antigenically dissimilar from vaccine strain 2013/14. "Age", "HMPV" and "Respiratory disease" showed an association with severe infection.

CONCLUSIONS: in this study an etiologic agent could be found in 60% of the acute respiratory episodes. These data provides information about the circulating viruses in ECC and highlights the importance of searching both viruses and atypical bacteria in severe ARI.

Original languageEnglish
Pages (from-to)1-7
JournalInternational Journal of Infectious Diseases
Volume69
Early online date29 Jan 2018
DOIs
Publication statusPublished - Apr 2018

Fingerprint

Metapneumovirus
Rhinovirus
Respiratory Tract Infections
Human bocavirus
Human respiratory syncytial virus
Human Influenza
Human parainfluenza virus 4
Population
Human parainfluenza virus 1
Viruses
Bacteria
Polymerase Chain Reaction
Coronavirus
Enterovirus
Virus Diseases
Infection
Adenoviridae
Vaccines

Keywords

  • Elderly
  • Elderly care centers
  • Legionella pneumophila
  • Real time PCR
  • Respiratory infections
  • Respiratory viruses

Cite this

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title = "Respiratory infections in elderly people: viral role in a resident population of elderly care centers in Lisbon, winter 2013-2014",
abstract = "OBJECTIVE: the aim of this study was to analyze the etiology and clinical consequences of viral respiratory infections in 18 elderly care centers (ECC) in Lisbon, which housed a total of 1022 residents.METHODS: nasopharyngeal swabs were collected whenever an elderly had symptoms of acute respiratory infections (ARI). PCR and RT-PCR were performed for influenza A/B, human parainfluenza virus 1-4, adenovirus, human metapneumovirus (HMPV), respiratory syncytial virus (RSV), rhinovirus, enterovirus, human coronavirus and human Bocavirus (HBoV). Array cards for atypical bacteria were also used in severe cases.RESULTS: in total, 188 episodes of ARI were reported, being rhinovirus the most frequently detected (n=53), followed by influenza A(H3) (n=19) and HBoV (n=14). Severe infections were reported in 19 patients, 11 of which were fatal, Legionela pneumophila, rhinovirus, HMPV and RSV associated with these fatalities. Nine influenza strains were analyzed, all antigenically dissimilar from vaccine strain 2013/14. {"}Age{"}, {"}HMPV{"} and {"}Respiratory disease{"} showed an association with severe infection.CONCLUSIONS: in this study an etiologic agent could be found in 60{\%} of the acute respiratory episodes. These data provides information about the circulating viruses in ECC and highlights the importance of searching both viruses and atypical bacteria in severe ARI.",
keywords = "Elderly, Elderly care centers, Legionella pneumophila, Real time PCR, Respiratory infections, Respiratory viruses",
author = "Maria-Jesus Chasqueira and Paulo Paix{\~a}o and Maria-L{\'u}cia Rodrigues and C{\'a}tia Piedade and Iolanda Caires and Teresa Palmeiro and Maria-Amalia Botelho and Madalena Santos and Martin Curran and Raquel Guiomar and Pedro Pechirra and In{\^e}s Costa and Ana Papoila and Marta Alves and Nuno Neuparth",
note = "info:eu-repo/grantAgreement/FCT/COMPETE/116563/PT# This work was supported by Foundation for Science and Technology (Fundacao para a Ciencia e Tecnologia - FCT, grant number PTDC/SAU-SAP/116563/2010) through Operational Competitiveness Programme (COMPETE) as part of the National Strategic Reference Framework.",
year = "2018",
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doi = "10.1016/j.ijid.2018.01.012",
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journal = "International Journal of Infectious Diseases",
issn = "1201-9712",
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TY - JOUR

T1 - Respiratory infections in elderly people

T2 - viral role in a resident population of elderly care centers in Lisbon, winter 2013-2014

AU - Chasqueira, Maria-Jesus

AU - Paixão, Paulo

AU - Rodrigues, Maria-Lúcia

AU - Piedade, Cátia

AU - Caires, Iolanda

AU - Palmeiro, Teresa

AU - Botelho, Maria-Amalia

AU - Santos, Madalena

AU - Curran, Martin

AU - Guiomar, Raquel

AU - Pechirra, Pedro

AU - Costa, Inês

AU - Papoila, Ana

AU - Alves, Marta

AU - Neuparth, Nuno

N1 - info:eu-repo/grantAgreement/FCT/COMPETE/116563/PT# This work was supported by Foundation for Science and Technology (Fundacao para a Ciencia e Tecnologia - FCT, grant number PTDC/SAU-SAP/116563/2010) through Operational Competitiveness Programme (COMPETE) as part of the National Strategic Reference Framework.

PY - 2018/4

Y1 - 2018/4

N2 - OBJECTIVE: the aim of this study was to analyze the etiology and clinical consequences of viral respiratory infections in 18 elderly care centers (ECC) in Lisbon, which housed a total of 1022 residents.METHODS: nasopharyngeal swabs were collected whenever an elderly had symptoms of acute respiratory infections (ARI). PCR and RT-PCR were performed for influenza A/B, human parainfluenza virus 1-4, adenovirus, human metapneumovirus (HMPV), respiratory syncytial virus (RSV), rhinovirus, enterovirus, human coronavirus and human Bocavirus (HBoV). Array cards for atypical bacteria were also used in severe cases.RESULTS: in total, 188 episodes of ARI were reported, being rhinovirus the most frequently detected (n=53), followed by influenza A(H3) (n=19) and HBoV (n=14). Severe infections were reported in 19 patients, 11 of which were fatal, Legionela pneumophila, rhinovirus, HMPV and RSV associated with these fatalities. Nine influenza strains were analyzed, all antigenically dissimilar from vaccine strain 2013/14. "Age", "HMPV" and "Respiratory disease" showed an association with severe infection.CONCLUSIONS: in this study an etiologic agent could be found in 60% of the acute respiratory episodes. These data provides information about the circulating viruses in ECC and highlights the importance of searching both viruses and atypical bacteria in severe ARI.

AB - OBJECTIVE: the aim of this study was to analyze the etiology and clinical consequences of viral respiratory infections in 18 elderly care centers (ECC) in Lisbon, which housed a total of 1022 residents.METHODS: nasopharyngeal swabs were collected whenever an elderly had symptoms of acute respiratory infections (ARI). PCR and RT-PCR were performed for influenza A/B, human parainfluenza virus 1-4, adenovirus, human metapneumovirus (HMPV), respiratory syncytial virus (RSV), rhinovirus, enterovirus, human coronavirus and human Bocavirus (HBoV). Array cards for atypical bacteria were also used in severe cases.RESULTS: in total, 188 episodes of ARI were reported, being rhinovirus the most frequently detected (n=53), followed by influenza A(H3) (n=19) and HBoV (n=14). Severe infections were reported in 19 patients, 11 of which were fatal, Legionela pneumophila, rhinovirus, HMPV and RSV associated with these fatalities. Nine influenza strains were analyzed, all antigenically dissimilar from vaccine strain 2013/14. "Age", "HMPV" and "Respiratory disease" showed an association with severe infection.CONCLUSIONS: in this study an etiologic agent could be found in 60% of the acute respiratory episodes. These data provides information about the circulating viruses in ECC and highlights the importance of searching both viruses and atypical bacteria in severe ARI.

KW - Elderly

KW - Elderly care centers

KW - Legionella pneumophila

KW - Real time PCR

KW - Respiratory infections

KW - Respiratory viruses

U2 - 10.1016/j.ijid.2018.01.012

DO - 10.1016/j.ijid.2018.01.012

M3 - Article

VL - 69

SP - 1

EP - 7

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

SN - 1201-9712

ER -