TY - JOUR
T1 - Respiratory infections in elderly people
T2 - viral role in a resident population of elderly care centers in Lisbon, winter 2013-2014
AU - Chasqueira, Maria-Jesus
AU - Paixão, Paulo
AU - Rodrigues, Maria-Lúcia
AU - Piedade, Cátia
AU - Caires, Iolanda
AU - Palmeiro, Teresa
AU - Botelho, Maria-Amalia
AU - Santos, Madalena
AU - Curran, Martin
AU - Guiomar, Raquel
AU - Pechirra, Pedro
AU - Costa, Inês
AU - Papoila, Ana
AU - Alves, Marta
AU - Neuparth, Nuno
N1 - info:eu-repo/grantAgreement/FCT/COMPETE/116563/PT#
This work was supported by Foundation for Science and Technology (Fundacao para a Ciencia e Tecnologia - FCT, grant number PTDC/SAU-SAP/116563/2010) through Operational Competitiveness Programme (COMPETE) as part of the National Strategic Reference Framework.
PY - 2018/4
Y1 - 2018/4
N2 - OBJECTIVE: the aim of this study was to analyze the etiology and clinical consequences of viral respiratory infections in 18 elderly care centers (ECC) in Lisbon, which housed a total of 1022 residents.METHODS: nasopharyngeal swabs were collected whenever an elderly had symptoms of acute respiratory infections (ARI). PCR and RT-PCR were performed for influenza A/B, human parainfluenza virus 1-4, adenovirus, human metapneumovirus (HMPV), respiratory syncytial virus (RSV), rhinovirus, enterovirus, human coronavirus and human Bocavirus (HBoV). Array cards for atypical bacteria were also used in severe cases.RESULTS: in total, 188 episodes of ARI were reported, being rhinovirus the most frequently detected (n=53), followed by influenza A(H3) (n=19) and HBoV (n=14). Severe infections were reported in 19 patients, 11 of which were fatal, Legionela pneumophila, rhinovirus, HMPV and RSV associated with these fatalities. Nine influenza strains were analyzed, all antigenically dissimilar from vaccine strain 2013/14. "Age", "HMPV" and "Respiratory disease" showed an association with severe infection.CONCLUSIONS: in this study an etiologic agent could be found in 60% of the acute respiratory episodes. These data provides information about the circulating viruses in ECC and highlights the importance of searching both viruses and atypical bacteria in severe ARI.
AB - OBJECTIVE: the aim of this study was to analyze the etiology and clinical consequences of viral respiratory infections in 18 elderly care centers (ECC) in Lisbon, which housed a total of 1022 residents.METHODS: nasopharyngeal swabs were collected whenever an elderly had symptoms of acute respiratory infections (ARI). PCR and RT-PCR were performed for influenza A/B, human parainfluenza virus 1-4, adenovirus, human metapneumovirus (HMPV), respiratory syncytial virus (RSV), rhinovirus, enterovirus, human coronavirus and human Bocavirus (HBoV). Array cards for atypical bacteria were also used in severe cases.RESULTS: in total, 188 episodes of ARI were reported, being rhinovirus the most frequently detected (n=53), followed by influenza A(H3) (n=19) and HBoV (n=14). Severe infections were reported in 19 patients, 11 of which were fatal, Legionela pneumophila, rhinovirus, HMPV and RSV associated with these fatalities. Nine influenza strains were analyzed, all antigenically dissimilar from vaccine strain 2013/14. "Age", "HMPV" and "Respiratory disease" showed an association with severe infection.CONCLUSIONS: in this study an etiologic agent could be found in 60% of the acute respiratory episodes. These data provides information about the circulating viruses in ECC and highlights the importance of searching both viruses and atypical bacteria in severe ARI.
KW - Elderly
KW - Elderly care centers
KW - Legionella pneumophila
KW - Real time PCR
KW - Respiratory infections
KW - Respiratory viruses
U2 - 10.1016/j.ijid.2018.01.012
DO - 10.1016/j.ijid.2018.01.012
M3 - Article
C2 - 29391246
SN - 1201-9712
VL - 69
SP - 1
EP - 7
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -
