Report of in vitro antileishmanial properties of Iberian macroalgae

Carolina Bruno de Sousa, Lago, João Henrique Ghilardi, Jorge Macridachis, Marta Oliveira, Luis Brito, Catarina Vizetto Duarte, Cláudia Florindo, Sarah Hendrickx, Maes, . Louis JRM., Morais, Thiago Rahal, Miriam Uemi, Luís Neto, Dionísio, Lídia Po Catalao, S Cortes, Luísa Barreira, Luísa Custódio, Fernando Albericio, L Campino, Varela, João CS

Research output: Contribution to journalArticle

Abstract

Here is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2 Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC50 29.8–101.8 μg/mL) inducing strong morphological alterations in the parasites. Hexane extracts of C. baccata and C. barbata were also active against intracellular amastigotes (IC50 5.1 and 6.8 μg/mL, respectively). Fatty acids, triacylglycerols, carotenoids, steroids and meroterpenoids were detected by nuclear magnetic resonance (NMR), and gas chromatography in the Cystoseira extracts. These results suggest that Cystoseira macroalgae contain compounds with antileishmanial activity, which could be explored as scaffolds to the development of novel sources of antiparasitic derivatives.
Original languageEnglish
Pages (from-to)1778-1782
Number of pages4
JournalNatural Product Research
VolumeVol. 33
Issue numbern.º 12
DOIs
Publication statusPublished - 18 Jun 2019

Keywords

  • Antiparasitic
  • Leishmaniasis
  • Macroalgae
  • Secondary metabolites

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    Bruno de Sousa, C., João Henrique Ghilardi, L., Macridachis, J., Oliveira, M., Brito, L., Duarte, C. V., ... João CS, V. (2019). Report of in vitro antileishmanial properties of Iberian macroalgae. Natural Product Research, Vol. 33(n.º 12), 1778-1782. https://doi.org/10.1080/14786419.2018.1434637