Report of in vitro antileishmanial properties of Iberian macroalgae

Carolina Bruno de Sousa; João Henrique Ghilardi Lago; Jorge Macridachis; Marta Oliveira; Luis Brito; Catarina Vizetto Duarte; Cláudia Florindo; Sarah Hendrickx; Louis JRM Maes; Thiago Rahal Morais; Miriam Uemi; Luís Neto; Dionísio,  Lídia Po Catalao; S Cortes; Luísa Barreira; Luísa Custódio; Fernando Albericio; L Campino; João CS Varela

doi:10.1080/14786419.2018.1434637

Report of in vitro antileishmanial properties of Iberian macroalgae

Carolina Bruno de Sousa, João Henrique Ghilardi Lago, Jorge Macridachis, Marta Oliveira, Luis Brito, Catarina Vizetto Duarte, Cláudia Florindo, Sarah Hendrickx, Louis JRM Maes, Thiago Rahal Morais, Miriam Uemi, Luís Neto, Dionísio, Lídia Po Catalao, S Cortes, Luísa Barreira, Luísa Custódio, Fernando Albericio, L Campino, João CS Varela

Research output: Contribution to journal › Article

Abstract

Here is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2 Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC50 29.8–101.8 μg/mL) inducing strong morphological alterations in the parasites. Hexane extracts of C. baccata and C. barbata were also active against intracellular amastigotes (IC50 5.1 and 6.8 μg/mL, respectively). Fatty acids, triacylglycerols, carotenoids, steroids and meroterpenoids were detected by nuclear magnetic resonance (NMR), and gas chromatography in the Cystoseira extracts. These results suggest that Cystoseira macroalgae contain compounds with antileishmanial activity, which could be explored as scaffolds to the development of novel sources of antiparasitic derivatives.

Original language	English
Pages (from-to)	1778-1782
Number of pages	4
Journal	Natural Product Research
Volume	33
Issue number	12
DOIs	https://doi.org/10.1080/14786419.2018.1434637
Publication status	Published - 18 Jun 2019

Keywords

Antiparasitic
Leishmaniasis
Macroalgae
Secondary metabolites

UN Sustainable Development Goals (SDGs)

SDG 3 - Good Health and Well-Being

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10.1080/14786419.2018.1434637

https://pubmed.ncbi.nlm.nih.gov/29424240-report-of-in-vitro-antileishmanial-properties-of-iberian-macroalgae/?from_single_result=Report+of+in+vitro+antileishmanial+properties+of+Iberian+macroalgae

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Bruno de Sousa, C., Lago, J. H. G., Macridachis, J., Oliveira, M., Brito, L., Duarte, C. V., Florindo, C., Hendrickx, S., Maes, L. JRM., Morais, T. R., Uemi, M., Neto, L., Lídia Po Catalao, D., Cortes, S., Barreira, L., Custódio, L., Albericio, F., Campino, L., & Varela, J. CS. (2019). Report of in vitro antileishmanial properties of Iberian macroalgae. Natural Product Research, 33(12), 1778-1782. https://doi.org/10.1080/14786419.2018.1434637

Bruno de Sousa, Carolina ; Lago, João Henrique Ghilardi ; Macridachis, Jorge ; Oliveira, Marta ; Brito, Luis ; Duarte, Catarina Vizetto ; Florindo, Cláudia ; Hendrickx, Sarah ; Maes, Louis JRM ; Morais, Thiago Rahal ; Uemi, Miriam ; Neto, Luís ; Lídia Po Catalao, Dionísio, ; Cortes, S ; Barreira, Luísa ; Custódio, Luísa ; Albericio, Fernando ; Campino, L ; Varela, João CS. / Report of in vitro antileishmanial properties of Iberian macroalgae. In: Natural Product Research. 2019 ; Vol. 33, No. 12. pp. 1778-1782.

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title = "Report of in vitro antileishmanial properties of Iberian macroalgae",

abstract = "Here is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2 Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC50 29.8–101.8 μg/mL) inducing strong morphological alterations in the parasites. Hexane extracts of C. baccata and C. barbata were also active against intracellular amastigotes (IC50 5.1 and 6.8 μg/mL, respectively). Fatty acids, triacylglycerols, carotenoids, steroids and meroterpenoids were detected by nuclear magnetic resonance (NMR), and gas chromatography in the Cystoseira extracts. These results suggest that Cystoseira macroalgae contain compounds with antileishmanial activity, which could be explored as scaffolds to the development of novel sources of antiparasitic derivatives.",

keywords = "Antiparasitic, Leishmaniasis, Macroalgae, Secondary metabolites",

author = "{Bruno de Sousa}, Carolina and Lago, {Jo{\~a}o Henrique Ghilardi} and Jorge Macridachis and Marta Oliveira and Luis Brito and Duarte, {Catarina Vizetto} and Cl{\'a}udia Florindo and Sarah Hendrickx and Maes, {Louis JRM} and Morais, {Thiago Rahal} and Miriam Uemi and Lu{\'i}s Neto and {L{\'i}dia Po Catalao}, Dion{\'i}sio, and S Cortes and Lu{\'i}sa Barreira and Lu{\'i}sa Cust{\'o}dio and Fernando Albericio and L Campino and Varela, {Jo{\~a}o CS}",

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doi = "10.1080/14786419.2018.1434637",

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Bruno de Sousa, C, Lago, JHG, Macridachis, J, Oliveira, M, Brito, L, Duarte, CV, Florindo, C, Hendrickx, S, Maes, LJRM, Morais, TR, Uemi, M, Neto, L, Lídia Po Catalao, D, Cortes, S, Barreira, L, Custódio, L, Albericio, F, Campino, L & Varela, JCS 2019, 'Report of in vitro antileishmanial properties of Iberian macroalgae', Natural Product Research, vol. 33, no. 12, pp. 1778-1782. https://doi.org/10.1080/14786419.2018.1434637

Report of in vitro antileishmanial properties of Iberian macroalgae. / Bruno de Sousa, Carolina; Lago, João Henrique Ghilardi; Macridachis, Jorge; Oliveira, Marta; Brito, Luis; Duarte, Catarina Vizetto; Florindo, Cláudia; Hendrickx, Sarah; Maes, Louis JRM; Morais, Thiago Rahal; Uemi, Miriam; Neto, Luís; Lídia Po Catalao, Dionísio, ; Cortes, S; Barreira, Luísa; Custódio, Luísa; Albericio, Fernando; Campino, L; Varela, João CS.

In: Natural Product Research, Vol. 33, No. 12, 18.06.2019, p. 1778-1782.

Research output: Contribution to journal › Article

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AU - Bruno de Sousa, Carolina

AU - Lago, João Henrique Ghilardi

AU - Macridachis, Jorge

AU - Oliveira, Marta

AU - Brito, Luis

AU - Duarte, Catarina Vizetto

AU - Florindo, Cláudia

AU - Hendrickx, Sarah

AU - Maes, Louis JRM

AU - Morais, Thiago Rahal

AU - Uemi, Miriam

AU - Neto, Luís

AU - Lídia Po Catalao, Dionísio,

AU - Cortes, S

AU - Barreira, Luísa

AU - Custódio, Luísa

AU - Albericio, Fernando

AU - Campino, L

AU - Varela, João CS

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N2 - Here is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2 Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC50 29.8–101.8 μg/mL) inducing strong morphological alterations in the parasites. Hexane extracts of C. baccata and C. barbata were also active against intracellular amastigotes (IC50 5.1 and 6.8 μg/mL, respectively). Fatty acids, triacylglycerols, carotenoids, steroids and meroterpenoids were detected by nuclear magnetic resonance (NMR), and gas chromatography in the Cystoseira extracts. These results suggest that Cystoseira macroalgae contain compounds with antileishmanial activity, which could be explored as scaffolds to the development of novel sources of antiparasitic derivatives.

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KW - Leishmaniasis

KW - Macroalgae

KW - Secondary metabolites

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