TY - JOUR
T1 - Report of in vitro antileishmanial properties of Iberian macroalgae
AU - Bruno de Sousa, Carolina
AU - Lago, João Henrique Ghilardi
AU - Macridachis, Jorge
AU - Oliveira, Marta
AU - Brito, Luis
AU - Duarte, Catarina Vizetto
AU - Florindo, Cláudia
AU - Hendrickx, Sarah
AU - Maes, Louis JRM
AU - Morais, Thiago Rahal
AU - Uemi, Miriam
AU - Neto, Luís
AU - Lídia Po Catalao, Dionísio,
AU - Cortes, S
AU - Barreira, Luísa
AU - Custódio, Luísa
AU - Albericio, Fernando
AU - Campino, L
AU - Varela, João CS
N1 - Funding Information:
This work was supported by the Foundation for Science andTechnology (FCT); the Portuguese National Budget [grant number PTDC/MAR/103957/2008], [grant number CCMAR/Multi/04326], [grant number GHTM-UID/Multi/04413/2013], [grant number SFRH/BD/78062/2011], [grant number SFRH/ BD/81425/2011], [grant number IF/00049/2012], [grant number IF/00743/2015]; the Brazilian institutions, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2019/6/18
Y1 - 2019/6/18
N2 - Here is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2 Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC50 29.8–101.8 μg/mL) inducing strong morphological alterations in the parasites. Hexane extracts of C. baccata and C. barbata were also active against intracellular amastigotes (IC50 5.1 and 6.8 μg/mL, respectively). Fatty acids, triacylglycerols, carotenoids, steroids and meroterpenoids were detected by nuclear magnetic resonance (NMR), and gas chromatography in the Cystoseira extracts. These results suggest that Cystoseira macroalgae contain compounds with antileishmanial activity, which could be explored as scaffolds to the development of novel sources of antiparasitic derivatives.
AB - Here is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2 Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC50 29.8–101.8 μg/mL) inducing strong morphological alterations in the parasites. Hexane extracts of C. baccata and C. barbata were also active against intracellular amastigotes (IC50 5.1 and 6.8 μg/mL, respectively). Fatty acids, triacylglycerols, carotenoids, steroids and meroterpenoids were detected by nuclear magnetic resonance (NMR), and gas chromatography in the Cystoseira extracts. These results suggest that Cystoseira macroalgae contain compounds with antileishmanial activity, which could be explored as scaffolds to the development of novel sources of antiparasitic derivatives.
KW - Antiparasitic
KW - Cystoseira
KW - Leishmania infantum
KW - leishmaniasis
KW - macroalgae
KW - secondary metabolites
UR - https://pubmed.ncbi.nlm.nih.gov/29424240-report-of-in-vitro-antileishmanial-properties-of-iberian-macroalgae/?from_single_result=Report+of+in+vitro+antileishmanial+properties+of+Iberian+macroalgae
UR - http://www.scopus.com/inward/record.url?scp=85041803574&partnerID=8YFLogxK
U2 - 10.1080/14786419.2018.1434637
DO - 10.1080/14786419.2018.1434637
M3 - Article
C2 - 29424240
VL - 33
SP - 1778
EP - 1782
JO - Natural Product Research
JF - Natural Product Research
SN - 1478-6419
IS - 12
ER -
