Renal regeneration after Acute Kidney Injury

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Acute kidney injury is common and associated with negative renal and patient outcomes. The human kidney has a real but limited regeneration capacity. Understanding renal regeneration may allow us to manipulate this process and thus develop therapeutic weapons to improve patients' outcome. In the first part of this paper we discuss the clinical factors associated with renal recovery: baseline patient particularities, acute kidney injury characteristics and the medical approach taken in the short and long-term. In the second part, the cellular and molecular mechanisms underlying renal regeneration are explored. The immune system seems to have an important role first promoting inflammation and then tissue healing. Other players, such as cellular senescence, mitochondrial dysfunction, renal hemodynamics and metabolic reprogramming also have a role in renal regeneration. We aim to develop a short review of renal regeneration, offering a holistic view of this process.

Original languageEnglish
Pages (from-to)805-814
JournalNephrology (Carlton, Vic.)
Volume23
Issue number9
Early online date25 Mar 2018
DOIs
Publication statusPublished - Sep 2018

Keywords

  • Acute Kidney Injury
  • immune system
  • inflammation
  • kidney
  • regeneration

Fingerprint Dive into the research topics of 'Renal regeneration after Acute Kidney Injury'. Together they form a unique fingerprint.

Cite this