Renal regeneration after Acute Kidney Injury

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Acute kidney injury is common and associated with negative renal and patient outcomes. The human kidney has a real but limited regeneration capacity. Understanding renal regeneration may allow us to manipulate this process and thus develop therapeutic weapons to improve patients' outcome. In the first part of this paper we discuss the clinical factors associated with renal recovery: baseline patient particularities, acute kidney injury characteristics and the medical approach taken in the short and long-term. In the second part, the cellular and molecular mechanisms underlying renal regeneration are explored. The immune system seems to have an important role first promoting inflammation and then tissue healing. Other players, such as cellular senescence, mitochondrial dysfunction, renal hemodynamics and metabolic reprogramming also have a role in renal regeneration. We aim to develop a short review of renal regeneration, offering a holistic view of this process.

Original languageEnglish
Pages (from-to)805-814
JournalNephrology (Carlton, Vic.)
Volume23
Issue number9
Early online date25 Mar 2018
DOIs
Publication statusPublished - Sep 2018

Fingerprint

Acute Kidney Injury
Regeneration
Kidney
Weapons
Cell Aging
Immune System
Hemodynamics
Inflammation

Keywords

  • Acute Kidney Injury
  • immune system
  • inflammation
  • kidney
  • regeneration

Cite this

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title = "Renal regeneration after Acute Kidney Injury",
abstract = "Acute kidney injury is common and associated with negative renal and patient outcomes. The human kidney has a real but limited regeneration capacity. Understanding renal regeneration may allow us to manipulate this process and thus develop therapeutic weapons to improve patients' outcome. In the first part of this paper we discuss the clinical factors associated with renal recovery: baseline patient particularities, acute kidney injury characteristics and the medical approach taken in the short and long-term. In the second part, the cellular and molecular mechanisms underlying renal regeneration are explored. The immune system seems to have an important role first promoting inflammation and then tissue healing. Other players, such as cellular senescence, mitochondrial dysfunction, renal hemodynamics and metabolic reprogramming also have a role in renal regeneration. We aim to develop a short review of renal regeneration, offering a holistic view of this process.",
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author = "Silvia Coelho and Guadalupe Cabral and Lopes, {Jos{\'e} Ant{\'o}nio} and Ant{\'o}nio Jacinto",
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Renal regeneration after Acute Kidney Injury. / Coelho, Silvia; Cabral, Guadalupe; Lopes, José António; Jacinto, António.

In: Nephrology (Carlton, Vic.), Vol. 23, No. 9, 09.2018, p. 805-814.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Renal regeneration after Acute Kidney Injury

AU - Coelho, Silvia

AU - Cabral, Guadalupe

AU - Lopes, José António

AU - Jacinto, António

N1 - This article is protected by copyright. All rights reserved.

PY - 2018/9

Y1 - 2018/9

N2 - Acute kidney injury is common and associated with negative renal and patient outcomes. The human kidney has a real but limited regeneration capacity. Understanding renal regeneration may allow us to manipulate this process and thus develop therapeutic weapons to improve patients' outcome. In the first part of this paper we discuss the clinical factors associated with renal recovery: baseline patient particularities, acute kidney injury characteristics and the medical approach taken in the short and long-term. In the second part, the cellular and molecular mechanisms underlying renal regeneration are explored. The immune system seems to have an important role first promoting inflammation and then tissue healing. Other players, such as cellular senescence, mitochondrial dysfunction, renal hemodynamics and metabolic reprogramming also have a role in renal regeneration. We aim to develop a short review of renal regeneration, offering a holistic view of this process.

AB - Acute kidney injury is common and associated with negative renal and patient outcomes. The human kidney has a real but limited regeneration capacity. Understanding renal regeneration may allow us to manipulate this process and thus develop therapeutic weapons to improve patients' outcome. In the first part of this paper we discuss the clinical factors associated with renal recovery: baseline patient particularities, acute kidney injury characteristics and the medical approach taken in the short and long-term. In the second part, the cellular and molecular mechanisms underlying renal regeneration are explored. The immune system seems to have an important role first promoting inflammation and then tissue healing. Other players, such as cellular senescence, mitochondrial dysfunction, renal hemodynamics and metabolic reprogramming also have a role in renal regeneration. We aim to develop a short review of renal regeneration, offering a holistic view of this process.

KW - Acute Kidney Injury

KW - immune system

KW - inflammation

KW - kidney

KW - regeneration

U2 - 10.1111/nep.13256

DO - 10.1111/nep.13256

M3 - Review article

VL - 23

SP - 805

EP - 814

JO - Nephrology (Carlton, Vic.)

JF - Nephrology (Carlton, Vic.)

SN - 1320-5358

IS - 9

ER -