Regulatory mechanisms of mitochondrial BKCa channels

Ana L. González-Cota, Carmen Santana-Calvo, Rocío Servín-Vences, Gerardo Orta, Enrique Balderas

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

The mitochondrial BKCa channel (mitoBKCa) is a splice variant of plasma membrane BKCa (Maxi-K, BKCa, Slo1, KCa1.1). While a high-resolution structure of mitoBKCa is not available yet, functional and structural studies of the plasma membrane BKCa have provided important clues on the gating of the channel by voltage and Ca2+, as well as the interaction with auxiliary subunits. To date, we know that the control of expression of mitoBKCa, targeting and voltage-sensitivity strongly depends on its association with its regulatory β1-subunit, which overall participate in the control of mitochondrial Ca2+-overload in cardiac myocytes. Moreover, novel regulatory mechanisms of mitoBKCa such as β-subunits and amyloid-β have recently been proposed. However, major basic questions including how the regulatory BKCa-β1-subunit reaches mitochondria and the mechanism through which amyloid-β impairs mitoBKCa channel function remain to be addressed.

Original languageEnglish
Pages (from-to)424-437
Number of pages14
JournalChannels
Volume15
Issue number1
DOIs
Publication statusPublished - 2021

Keywords

  • amyloid beta
  • beta subunits
  • BK channels
  • DEC sequence
  • genetic origin
  • Maxi-K channels
  • Mitochondria

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