Regulating the regulators

Research output: Contribution to journalArticle

Abstract

Gene regulation was long thought to be controlled almost entirely by proteins that bind to DNA and RNA. Over the last years, it has become clear that small non-coding RNAs (sRNAs) are important in almost every facet of gene regulation. Understanding how they are matured and degraded has therefore become of maximum importance, in order to know how to "regulate the regulators." Ribonucleases perform a key role in the biogenesis and processing of sRNAs, as well as in controlling their cellular levels through regulation of their turnover. Accordingly, RNases can have a major impact on sRNAs regulatory pathways. In this review, we present an overview of what is presently known about the main RNases, as well as other factors involved in sRNA processing and turnover, in essence contributing to the assembly of the increasing number of pieces in the puzzling global mechanism of sRNA regulation. Although the primary focus will be on bacterial sRNAs, parallels will be made with the siRNAs and miRNAs in eukaryotes.
Original languageUnknown
Pages (from-to)230-243
JournalRna Biology
Volume5
Issue number4
Publication statusPublished - 1 Jan 2008

Cite this

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abstract = "Gene regulation was long thought to be controlled almost entirely by proteins that bind to DNA and RNA. Over the last years, it has become clear that small non-coding RNAs (sRNAs) are important in almost every facet of gene regulation. Understanding how they are matured and degraded has therefore become of maximum importance, in order to know how to {"}regulate the regulators.{"} Ribonucleases perform a key role in the biogenesis and processing of sRNAs, as well as in controlling their cellular levels through regulation of their turnover. Accordingly, RNases can have a major impact on sRNAs regulatory pathways. In this review, we present an overview of what is presently known about the main RNases, as well as other factors involved in sRNA processing and turnover, in essence contributing to the assembly of the increasing number of pieces in the puzzling global mechanism of sRNA regulation. Although the primary focus will be on bacterial sRNAs, parallels will be made with the siRNAs and miRNAs in eukaryotes.",
keywords = "antisense RNA, processing, post-transcriptional control, miRNA, degradation, sRNA, Hfq, RNase, siRNA",
author = "Arraiano, {Cecilia Maria} and Viegas, {Sandra Cristina}",
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month = "1",
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journal = "Rna Biology",
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Regulating the regulators. / Arraiano, Cecilia Maria; Viegas, Sandra Cristina.

In: Rna Biology, Vol. 5, No. 4, 01.01.2008, p. 230-243.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Regulating the regulators

AU - Arraiano, Cecilia Maria

AU - Viegas, Sandra Cristina

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Gene regulation was long thought to be controlled almost entirely by proteins that bind to DNA and RNA. Over the last years, it has become clear that small non-coding RNAs (sRNAs) are important in almost every facet of gene regulation. Understanding how they are matured and degraded has therefore become of maximum importance, in order to know how to "regulate the regulators." Ribonucleases perform a key role in the biogenesis and processing of sRNAs, as well as in controlling their cellular levels through regulation of their turnover. Accordingly, RNases can have a major impact on sRNAs regulatory pathways. In this review, we present an overview of what is presently known about the main RNases, as well as other factors involved in sRNA processing and turnover, in essence contributing to the assembly of the increasing number of pieces in the puzzling global mechanism of sRNA regulation. Although the primary focus will be on bacterial sRNAs, parallels will be made with the siRNAs and miRNAs in eukaryotes.

AB - Gene regulation was long thought to be controlled almost entirely by proteins that bind to DNA and RNA. Over the last years, it has become clear that small non-coding RNAs (sRNAs) are important in almost every facet of gene regulation. Understanding how they are matured and degraded has therefore become of maximum importance, in order to know how to "regulate the regulators." Ribonucleases perform a key role in the biogenesis and processing of sRNAs, as well as in controlling their cellular levels through regulation of their turnover. Accordingly, RNases can have a major impact on sRNAs regulatory pathways. In this review, we present an overview of what is presently known about the main RNases, as well as other factors involved in sRNA processing and turnover, in essence contributing to the assembly of the increasing number of pieces in the puzzling global mechanism of sRNA regulation. Although the primary focus will be on bacterial sRNAs, parallels will be made with the siRNAs and miRNAs in eukaryotes.

KW - antisense RNA

KW - processing

KW - post-transcriptional control

KW - miRNA

KW - degradation

KW - sRNA

KW - Hfq

KW - RNase

KW - siRNA

M3 - Article

VL - 5

SP - 230

EP - 243

JO - Rna Biology

JF - Rna Biology

SN - 1547-6286

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