Reference values for spirometry in elderly individuals

A cross-sectional study of different reference equations

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Abstract

Background: Spirometry is the single most important test for the evaluation of respiratory function. The results are interpreted by comparing measured data with predicted values previously obtained from a reference population. Reference equations for spirometry have been discussed previously. The aim of this study was to compare reference values based on National Health and Nutrition Assessment Survey (NHANES III), European Community of Steel and Coal (ECSC), and Global Lung Initiative (GLI) equations in an elderly sample population. Methods: Subjects from the Geriatric Study on Health Effects of Air Quality in elder care centres who met the inclusion criteria were enrolled. Spirometry was performed according to international guidelines. The forced vital capacity, forced expiratory volume in 1 s, and FEV1/FVC ratio were reported as percentages of the predicted value, and the lower limit of normality was calculated. Results: Out of 260 elderly patients, 69.6% were women; the mean age was 83.0 ± 6.46 years with an age range of 65-95 years. The lowest %FVC and %FEV1 values were obtained using the GLI reference equations. However, when NHANES III equations were used, the FEV1/FVC ratio was higher than ratios obtained from GLI and ECSC equations. The prevalence of airway obstruction was highest using ECSC equations, while GLI equations demonstrated more restrictive defects. Conclusions: The present study showed meaningful differences in the reference values, and consequently, in the results obtained using NHANES III, ECSC, and GLI reference equations. The spirometry interpretation was also influenced by the reference equations used.

Original languageEnglish
Article number4
JournalMultidisciplinary Respiratory Medicine
Volume13
Issue number1
DOIs
Publication statusPublished - 9 Jan 2018

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Spirometry
Nutrition Surveys
European Union
Reference Values
Cross-Sectional Studies
Lung
Nutrition Assessment
Respiratory Function Tests
Vital Capacity
Health
Forced Expiratory Volume
Airway Obstruction
Geriatrics
Population
Air
Guidelines

Keywords

  • ECSC
  • Elderly
  • GLI
  • NHANES III
  • Reference eqs.
  • Spirometry

Cite this

@article{4b246933febe4f23a896d2d2acabf99b,
title = "Reference values for spirometry in elderly individuals: A cross-sectional study of different reference equations",
abstract = "Background: Spirometry is the single most important test for the evaluation of respiratory function. The results are interpreted by comparing measured data with predicted values previously obtained from a reference population. Reference equations for spirometry have been discussed previously. The aim of this study was to compare reference values based on National Health and Nutrition Assessment Survey (NHANES III), European Community of Steel and Coal (ECSC), and Global Lung Initiative (GLI) equations in an elderly sample population. Methods: Subjects from the Geriatric Study on Health Effects of Air Quality in elder care centres who met the inclusion criteria were enrolled. Spirometry was performed according to international guidelines. The forced vital capacity, forced expiratory volume in 1 s, and FEV1/FVC ratio were reported as percentages of the predicted value, and the lower limit of normality was calculated. Results: Out of 260 elderly patients, 69.6{\%} were women; the mean age was 83.0 ± 6.46 years with an age range of 65-95 years. The lowest {\%}FVC and {\%}FEV1 values were obtained using the GLI reference equations. However, when NHANES III equations were used, the FEV1/FVC ratio was higher than ratios obtained from GLI and ECSC equations. The prevalence of airway obstruction was highest using ECSC equations, while GLI equations demonstrated more restrictive defects. Conclusions: The present study showed meaningful differences in the reference values, and consequently, in the results obtained using NHANES III, ECSC, and GLI reference equations. The spirometry interpretation was also influenced by the reference equations used.",
keywords = "ECSC, Elderly, GLI, NHANES III, Reference eqs., Spirometry",
author = "Joana Belo and Teresa Palmeiro and Iolanda Caires and Papoila, {Ana L.} and Marta Alves and Pedro Carreiro-Martins and Botelho, {Maria A.} and Nuno Neuparth",
year = "2018",
month = "1",
day = "9",
doi = "10.1186/s40248-017-0112-5",
language = "English",
volume = "13",
journal = "Multidisciplinary Respiratory Medicine",
issn = "1828-695X",
publisher = "Springer Verlag",
number = "1",

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TY - JOUR

T1 - Reference values for spirometry in elderly individuals

T2 - A cross-sectional study of different reference equations

AU - Belo, Joana

AU - Palmeiro, Teresa

AU - Caires, Iolanda

AU - Papoila, Ana L.

AU - Alves, Marta

AU - Carreiro-Martins, Pedro

AU - Botelho, Maria A.

AU - Neuparth, Nuno

PY - 2018/1/9

Y1 - 2018/1/9

N2 - Background: Spirometry is the single most important test for the evaluation of respiratory function. The results are interpreted by comparing measured data with predicted values previously obtained from a reference population. Reference equations for spirometry have been discussed previously. The aim of this study was to compare reference values based on National Health and Nutrition Assessment Survey (NHANES III), European Community of Steel and Coal (ECSC), and Global Lung Initiative (GLI) equations in an elderly sample population. Methods: Subjects from the Geriatric Study on Health Effects of Air Quality in elder care centres who met the inclusion criteria were enrolled. Spirometry was performed according to international guidelines. The forced vital capacity, forced expiratory volume in 1 s, and FEV1/FVC ratio were reported as percentages of the predicted value, and the lower limit of normality was calculated. Results: Out of 260 elderly patients, 69.6% were women; the mean age was 83.0 ± 6.46 years with an age range of 65-95 years. The lowest %FVC and %FEV1 values were obtained using the GLI reference equations. However, when NHANES III equations were used, the FEV1/FVC ratio was higher than ratios obtained from GLI and ECSC equations. The prevalence of airway obstruction was highest using ECSC equations, while GLI equations demonstrated more restrictive defects. Conclusions: The present study showed meaningful differences in the reference values, and consequently, in the results obtained using NHANES III, ECSC, and GLI reference equations. The spirometry interpretation was also influenced by the reference equations used.

AB - Background: Spirometry is the single most important test for the evaluation of respiratory function. The results are interpreted by comparing measured data with predicted values previously obtained from a reference population. Reference equations for spirometry have been discussed previously. The aim of this study was to compare reference values based on National Health and Nutrition Assessment Survey (NHANES III), European Community of Steel and Coal (ECSC), and Global Lung Initiative (GLI) equations in an elderly sample population. Methods: Subjects from the Geriatric Study on Health Effects of Air Quality in elder care centres who met the inclusion criteria were enrolled. Spirometry was performed according to international guidelines. The forced vital capacity, forced expiratory volume in 1 s, and FEV1/FVC ratio were reported as percentages of the predicted value, and the lower limit of normality was calculated. Results: Out of 260 elderly patients, 69.6% were women; the mean age was 83.0 ± 6.46 years with an age range of 65-95 years. The lowest %FVC and %FEV1 values were obtained using the GLI reference equations. However, when NHANES III equations were used, the FEV1/FVC ratio was higher than ratios obtained from GLI and ECSC equations. The prevalence of airway obstruction was highest using ECSC equations, while GLI equations demonstrated more restrictive defects. Conclusions: The present study showed meaningful differences in the reference values, and consequently, in the results obtained using NHANES III, ECSC, and GLI reference equations. The spirometry interpretation was also influenced by the reference equations used.

KW - ECSC

KW - Elderly

KW - GLI

KW - NHANES III

KW - Reference eqs.

KW - Spirometry

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U2 - 10.1186/s40248-017-0112-5

DO - 10.1186/s40248-017-0112-5

M3 - Article

VL - 13

JO - Multidisciplinary Respiratory Medicine

JF - Multidisciplinary Respiratory Medicine

SN - 1828-695X

IS - 1

M1 - 4

ER -