Recycling the Interspecific Relations with Epithelial Cells: Bacteria and Cancer Metabolic Symbiosis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Several aspects of the human physiology are controlled by the microbiota that plays a key role in health and disease. In fact, microbial dysbiosis is associated with numerous diseases, including several types of cancer such as colon, gastric, esophageal, pancreatic, laryngeal, breast and gallbladder carcinomas.Metabolic symbiosis between non-malignant cells and the resident microbita is crucial for the host homeostasis. However, cancer cells are able to repurpose the pre-existing metabolic symbiosis, being able to recycle those relations and also create novel metabolic symbiosis, leading to profound alterations on the local microenvironment.In here we will explore some of these symbiotic metabolic interactions between bacteria and non-malignant cells in two different contexts: colon and uterine cervix. The way malignant cells are able to recycle these normal interactions and also create novel types of symbiotic metabolic relations will also be discussed.The knowledge of these complex interactions and recycling mechanisms is of extreme importance for cancer treatment, as new therapeutic targets could be developed.

Original languageEnglish
Pages (from-to)77-91
Number of pages15
JournalAdvances in Experimental Medicine and Biology
Volume1219
DOIs
Publication statusPublished - 2020

Keywords

  • Uterine cervix cancer
  • Colon cancer
  • Microflora
  • Metabolic symbiosis
  • Symbiosis bacteria
  • Epithelial cells
  • Lactate
  • Butyrate

Fingerprint Dive into the research topics of 'Recycling the Interspecific Relations with Epithelial Cells: Bacteria and Cancer Metabolic Symbiosis'. Together they form a unique fingerprint.

  • Cite this