Recent life events pose greatest risk for onset of major depressive disorder during mid-life

Bauke T. Stegenga, Irwin Nazareth, Diederick E. Grobbee, Francisco Torres-González, Igor Švab, Heidi Ingrid Maaroos, Miguel Xavier, Sandra Saldivia, Christian Bottomley, Michael King, Mirjam I. Geerlings

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: The authors examined an additive model for the association of life events and age with onset of major depressive disorder (MDD) and whether the combination of life events and age posed greater risk than the sum of their independent effects. Methods: Data were used from a prospective cohort study of 10,045 general practice attendees (PredictD). We included those without MDD at baseline (N = 8293). We examined age divided into tertiles and into 10 year groups. Life events were assessed at baseline using the List of Threatening Life Experiences Questionnaire and categorized according to type. Main outcome measure was onset of DSM-IV MDD at 6 or 12 months of follow-up. The authors calculated Relative Excess Risks due to Interaction (RERI). Results: 6910 persons (83.3%) had a complete follow-up, of whom 589 (8.5%) had an onset of MDD (166 younger, 254 middle aged and 169 older). The combined effect of personal problems (RERI = 1.30; 95% CI 0.29 to 2.32), events in family or friends (RERI = 1.23; 95% CI 0.28 to 2.19), or problems with law (RERI = 1.57; 95% CI 0.33 to 2.82) and middle age was larger than the sum of individual effects. Limitations: Lower response to recruitment in the UK and the Netherlands. Conclusions: Recent life events carry the largest risk of onset of MDD in mid-life. Understanding the different vulnerability to life events according to age may help to indicate groups at a particular risk and assist in preventive strategies.

Original languageEnglish
Pages (from-to)505-513
Number of pages9
JournalJournal of Affective Disorders
Volume136
Issue number3
DOIs
Publication statusPublished - Feb 2012

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Major Depressive Disorder
Life Change Events
Age of Onset
Diagnostic and Statistical Manual of Mental Disorders
General Practice
Netherlands
Cohort Studies
Outcome Assessment (Health Care)
Prospective Studies

Keywords

  • Age
  • Cohort
  • Interaction
  • Major depression
  • Stress

Cite this

Stegenga, B. T., Nazareth, I., Grobbee, D. E., Torres-González, F., Švab, I., Maaroos, H. I., ... Geerlings, M. I. (2012). Recent life events pose greatest risk for onset of major depressive disorder during mid-life. Journal of Affective Disorders, 136(3), 505-513. https://doi.org/10.1016/j.jad.2011.10.041
Stegenga, Bauke T. ; Nazareth, Irwin ; Grobbee, Diederick E. ; Torres-González, Francisco ; Švab, Igor ; Maaroos, Heidi Ingrid ; Xavier, Miguel ; Saldivia, Sandra ; Bottomley, Christian ; King, Michael ; Geerlings, Mirjam I. / Recent life events pose greatest risk for onset of major depressive disorder during mid-life. In: Journal of Affective Disorders. 2012 ; Vol. 136, No. 3. pp. 505-513.
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abstract = "Background: The authors examined an additive model for the association of life events and age with onset of major depressive disorder (MDD) and whether the combination of life events and age posed greater risk than the sum of their independent effects. Methods: Data were used from a prospective cohort study of 10,045 general practice attendees (PredictD). We included those without MDD at baseline (N = 8293). We examined age divided into tertiles and into 10 year groups. Life events were assessed at baseline using the List of Threatening Life Experiences Questionnaire and categorized according to type. Main outcome measure was onset of DSM-IV MDD at 6 or 12 months of follow-up. The authors calculated Relative Excess Risks due to Interaction (RERI). Results: 6910 persons (83.3{\%}) had a complete follow-up, of whom 589 (8.5{\%}) had an onset of MDD (166 younger, 254 middle aged and 169 older). The combined effect of personal problems (RERI = 1.30; 95{\%} CI 0.29 to 2.32), events in family or friends (RERI = 1.23; 95{\%} CI 0.28 to 2.19), or problems with law (RERI = 1.57; 95{\%} CI 0.33 to 2.82) and middle age was larger than the sum of individual effects. Limitations: Lower response to recruitment in the UK and the Netherlands. Conclusions: Recent life events carry the largest risk of onset of MDD in mid-life. Understanding the different vulnerability to life events according to age may help to indicate groups at a particular risk and assist in preventive strategies.",
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Stegenga, BT, Nazareth, I, Grobbee, DE, Torres-González, F, Švab, I, Maaroos, HI, Xavier, M, Saldivia, S, Bottomley, C, King, M & Geerlings, MI 2012, 'Recent life events pose greatest risk for onset of major depressive disorder during mid-life', Journal of Affective Disorders, vol. 136, no. 3, pp. 505-513. https://doi.org/10.1016/j.jad.2011.10.041

Recent life events pose greatest risk for onset of major depressive disorder during mid-life. / Stegenga, Bauke T.; Nazareth, Irwin; Grobbee, Diederick E.; Torres-González, Francisco; Švab, Igor; Maaroos, Heidi Ingrid; Xavier, Miguel; Saldivia, Sandra; Bottomley, Christian; King, Michael; Geerlings, Mirjam I.

In: Journal of Affective Disorders, Vol. 136, No. 3, 02.2012, p. 505-513.

Research output: Contribution to journalArticle

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T1 - Recent life events pose greatest risk for onset of major depressive disorder during mid-life

AU - Stegenga, Bauke T.

AU - Nazareth, Irwin

AU - Grobbee, Diederick E.

AU - Torres-González, Francisco

AU - Švab, Igor

AU - Maaroos, Heidi Ingrid

AU - Xavier, Miguel

AU - Saldivia, Sandra

AU - Bottomley, Christian

AU - King, Michael

AU - Geerlings, Mirjam I.

PY - 2012/2

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N2 - Background: The authors examined an additive model for the association of life events and age with onset of major depressive disorder (MDD) and whether the combination of life events and age posed greater risk than the sum of their independent effects. Methods: Data were used from a prospective cohort study of 10,045 general practice attendees (PredictD). We included those without MDD at baseline (N = 8293). We examined age divided into tertiles and into 10 year groups. Life events were assessed at baseline using the List of Threatening Life Experiences Questionnaire and categorized according to type. Main outcome measure was onset of DSM-IV MDD at 6 or 12 months of follow-up. The authors calculated Relative Excess Risks due to Interaction (RERI). Results: 6910 persons (83.3%) had a complete follow-up, of whom 589 (8.5%) had an onset of MDD (166 younger, 254 middle aged and 169 older). The combined effect of personal problems (RERI = 1.30; 95% CI 0.29 to 2.32), events in family or friends (RERI = 1.23; 95% CI 0.28 to 2.19), or problems with law (RERI = 1.57; 95% CI 0.33 to 2.82) and middle age was larger than the sum of individual effects. Limitations: Lower response to recruitment in the UK and the Netherlands. Conclusions: Recent life events carry the largest risk of onset of MDD in mid-life. Understanding the different vulnerability to life events according to age may help to indicate groups at a particular risk and assist in preventive strategies.

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Stegenga BT, Nazareth I, Grobbee DE, Torres-González F, Švab I, Maaroos HI et al. Recent life events pose greatest risk for onset of major depressive disorder during mid-life. Journal of Affective Disorders. 2012 Feb;136(3):505-513. https://doi.org/10.1016/j.jad.2011.10.041