TY - JOUR
T1 - Recent Developments in Clinical Plasma Proteomics—Applied to Cardiovascular Research
AU - Palstrøm, Nicolai Bjødstrup
AU - Matthiesen, Rune
AU - Rasmussen, Lars Melholt
AU - Beck, Hans Christian
N1 - Funding Information:
Funding: Odense University Hospital Research Fund (grant no. A3130 and A3329) and The Danish Heart Foundation.
PY - 2022/1
Y1 - 2022/1
N2 - The human plasma proteome mirrors the physiological state of the cardiovascular system, a fact that has been used to analyze plasma biomarkers in routine analysis for the diagnosis and monitoring of cardiovascular diseases for decades. These biomarkers address, however, only a very limited subset of cardiovascular diseases, such as acute myocardial infarct or acute deep vein thrombosis, and clinical plasma biomarkers for the diagnosis and stratification cardiovascular diseases that are growing in incidence, such as heart failure and abdominal aortic aneurysm, do not exist and are urgently needed. The discovery of novel biomarkers in plasma has been hindered by the complexity of the human plasma proteome that again transforms into an extreme analytical complexity when it comes to the discovery of novel plasma biomarkers. This complexity is, however, addressed by recent achievements in technologies for analyzing the human plasma proteome, thereby facilitating the possibility for novel biomarker discoveries. The aims of this article is to provide an overview of the recent achievements in technologies for proteomic analysis of the human plasma proteome and their applications in cardiovascular medicine.
AB - The human plasma proteome mirrors the physiological state of the cardiovascular system, a fact that has been used to analyze plasma biomarkers in routine analysis for the diagnosis and monitoring of cardiovascular diseases for decades. These biomarkers address, however, only a very limited subset of cardiovascular diseases, such as acute myocardial infarct or acute deep vein thrombosis, and clinical plasma biomarkers for the diagnosis and stratification cardiovascular diseases that are growing in incidence, such as heart failure and abdominal aortic aneurysm, do not exist and are urgently needed. The discovery of novel biomarkers in plasma has been hindered by the complexity of the human plasma proteome that again transforms into an extreme analytical complexity when it comes to the discovery of novel plasma biomarkers. This complexity is, however, addressed by recent achievements in technologies for analyzing the human plasma proteome, thereby facilitating the possibility for novel biomarker discoveries. The aims of this article is to provide an overview of the recent achievements in technologies for proteomic analysis of the human plasma proteome and their applications in cardiovascular medicine.
KW - Affinity proteomics
KW - Cardiovascular disease
KW - Mass spectrometry-based proteomics
KW - Plasma proteomics
UR - http://www.scopus.com/inward/record.url?scp=85123607866&partnerID=8YFLogxK
U2 - 10.3390/biomedicines10010162
DO - 10.3390/biomedicines10010162
M3 - Review article
AN - SCOPUS:85123607866
SN - 2227-9059
VL - 10
JO - Biomedicines
JF - Biomedicines
IS - 1
M1 - 162
ER -
