Recent advances in the histological and molecular classification of endometrial stromal neoplasms

Joana Ferreira, Ana Félix, Jochen K Lennerz, Esther Oliva

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

This review addresses known features and recent developments in the histological, immunohistochemical, and molecular characterization of endometrial stromal neoplasms. We discuss the spectrum of these tumors, from the benign endometrial stromal nodule to low-grade endometrial stromal sarcoma to uterine undifferentiated sarcomas with a special emphasis on the expanding group of high-grade stromal sarcomas, recently added to the 2014 WHO classification, not only discussing the well-established YWHAE-FAM22 tumors but also two new groups, presenting with BCOR alterations including those with BCOR tandem internal duplications or NTRK fusions. It is likely that this high-grade category of endometrial stromal tumors will expand as increasing molecular data is available.

Original languageEnglish
Pages (from-to)665-678
JournalVirchows Archiv : an international journal of pathology
Volume473
Issue number6
Early online date15 Oct 2018
DOIs
Publication statusPublished - 1 Dec 2018

Keywords

  • Endometrial stromal sarcoma
  • Molecular
  • Sarcoma
  • Translocations
  • Uterus

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