TY - JOUR
T1 - Rearranged Jatrophane-Type Diterpenes from Euphorbia Species
T2 - Evaluation of their Effects on the Reversal of Multidrug Resistance
AU - Madureira, Ana Margarida
AU - Ferreira, Maria José Umbelino
AU - Gyémánt, Nora
AU - Ugocsai, Katalin
AU - Ascenso, José R.
AU - Abreu, Pedro M.
AU - Hohmann, Judit
AU - Molnár, Joseph
PY - 2004/1
Y1 - 2004/1
N2 - The rearranged jatrophane-type diterpenes (1-3), isolated from the Me 2CO extracts of Euphorbia portlandica and Euphorbia segetalis, were examined for their effects on multidrug resistance (MDR) in mouse lymphoma cells. Compounds 2 and 3 revealed to be active with the latter being more active than the positive control verapamil, a known resistance modifier. The new compound 1, named portlandicine, was isolated from Euphorbia portlandica and its structure characterised by high-field NMR spectroscopic methods including 2D NMR techniques: COSY, HMQC, HMBC and NOESY. The known diterpene 2, together with aleuritolic acid (4), oleanolic acid (5), and betulin diacetate (6), were also isolated from the same species.
AB - The rearranged jatrophane-type diterpenes (1-3), isolated from the Me 2CO extracts of Euphorbia portlandica and Euphorbia segetalis, were examined for their effects on multidrug resistance (MDR) in mouse lymphoma cells. Compounds 2 and 3 revealed to be active with the latter being more active than the positive control verapamil, a known resistance modifier. The new compound 1, named portlandicine, was isolated from Euphorbia portlandica and its structure characterised by high-field NMR spectroscopic methods including 2D NMR techniques: COSY, HMQC, HMBC and NOESY. The known diterpene 2, together with aleuritolic acid (4), oleanolic acid (5), and betulin diacetate (6), were also isolated from the same species.
KW - Diterpenes
KW - Euphorbia portlandica
KW - Euphorbia segetalis
KW - Euphorbiaceae
KW - Jatrophane
KW - Multidrug resistance
KW - Triterpenes
UR - http://www.scopus.com/inward/record.url?scp=1242320327&partnerID=8YFLogxK
U2 - 10.1055/s-2004-815454
DO - 10.1055/s-2004-815454
M3 - Article
C2 - 14765292
SN - 0032-0943
VL - 70
SP - 45
EP - 49
JO - Planta Medica
JF - Planta Medica
IS - 1
ER -