Rearranged Jatrophane-Type Diterpenes from Euphorbia Species: Evaluation of their Effects on the Reversal of Multidrug Resistance

Ana Margarida Madureira, Maria José Umbelino Ferreira, Nora Gyémánt, Katalin Ugocsai, José R. Ascenso, Pedro M. Abreu, Judit Hohmann, Joseph Molnár

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The rearranged jatrophane-type diterpenes (1-3), isolated from the Me 2CO extracts of Euphorbia portlandica and Euphorbia segetalis, were examined for their effects on multidrug resistance (MDR) in mouse lymphoma cells. Compounds 2 and 3 revealed to be active with the latter being more active than the positive control verapamil, a known resistance modifier. The new compound 1, named portlandicine, was isolated from Euphorbia portlandica and its structure characterised by high-field NMR spectroscopic methods including 2D NMR techniques: COSY, HMQC, HMBC and NOESY. The known diterpene 2, together with aleuritolic acid (4), oleanolic acid (5), and betulin diacetate (6), were also isolated from the same species.

Original languageEnglish
Pages (from-to)45-49
Number of pages5
JournalPlanta Medica
Volume70
Issue number1
DOIs
Publication statusPublished - Jan 2004

Keywords

  • Diterpenes
  • Euphorbia portlandica
  • Euphorbia segetalis
  • Euphorbiaceae
  • Jatrophane
  • Multidrug resistance
  • Triterpenes

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