Real‐life data on heart failure before and after implantation of resynchronization and/or defibrillation devices – the Síncrone study: dados da vida real ‐ o Estudo Síncrone

Daniel Bonhorst, Sara Guerreiro, Cândida Fonseca, Nuno Cardim, Filipe Macedo, Pedro Adragão

Research output: Contribution to journalArticle

Abstract

Introduction: The aim of this study was to document clinical practice in Portugal regarding the use of electronic cardiac devices in patients with heart failure (HF) and reduced left ventricular ejection fraction (LVEF). Methods: The Síncrone study was an observational prospective multicenter registry conducted in 16 centers in Portugal between 2006 and 2014. It included adult patients with a diagnosis of HF, LVEF <35% and indication for implantable cardioverter‐defibrillator (ICD) and/or cardiac resynchronization therapy (CRT) devices, according to the recommendations of the European Society of Cardiology at the beginning of the study. Patients were followed for one year according to the practice of each center. Results: A total of 486 patients were included in the registry, half of whom received an ICD and the other half a CRT pacemaker (CRT‐P) or CRT defibrillator (CRT‐D). Mean age was 65±12 years and the most frequent causes of HF were ischemic (47%) and idiopathic dilated cardiomyopathy (28%). Overall mortality at one year was 3.6% and the hospitalization rate was 11%, significantly higher in patients with CRT‐P/CRT‐D than with ICD (17% vs. 5.6%, p<0.001). Patients who received CRT‐P/CRT‐D experienced significant reductions in QRS duration (160±21 vs. 141±24 ms, p<0.001) as well as improvement in New York Heart Association functional class. Conclusion: The Síncrone study shows that the use of implantable devices in HF with reduced LVEF in Portugal is in accordance with international recommendations and that patients presented functional improvement and reduced one‐year mortality.

Translated title of the contributionReal‐life data on heart failure before and after implantation of resynchronization and/or defibrillation devices – the Síncrone study
Original languagePortuguese
Pages (from-to)33-41
Number of pages9
JournalRevista Portuguesa de Cardiologia
Volume38
Issue number1
DOIs
Publication statusPublished - Jan 2019

Fingerprint

Heart Failure
Equipment and Supplies
Portugal
Stroke Volume
Cardiac Resynchronization Therapy
Defibrillators
Registries
Cardiac Resynchronization Therapy Devices
Mortality
Implantable Defibrillators
Dilated Cardiomyopathy
Observational Studies
Hospitalization

Keywords

  • Heart failure
  • Hospitalization
  • Implantable cardiac devices
  • Mortality
  • Reduced left ventricular ejection fraction
  • Resynchronization

Cite this

@article{9763ee605c0044a983693ed817c03a88,
title = "Implanta{\cc}{\~a}o de dispositivos de ressincroniza{\cc}{\~a}o e/ou desfibrilha{\cc}{\~a}o em doentes com insufici{\^e}ncia card{\'i}aca: dados da vida real ‐ o Estudo S{\'i}ncrone",
abstract = "Introduction: The aim of this study was to document clinical practice in Portugal regarding the use of electronic cardiac devices in patients with heart failure (HF) and reduced left ventricular ejection fraction (LVEF). Methods: The S{\'i}ncrone study was an observational prospective multicenter registry conducted in 16 centers in Portugal between 2006 and 2014. It included adult patients with a diagnosis of HF, LVEF <35{\%} and indication for implantable cardioverter‐defibrillator (ICD) and/or cardiac resynchronization therapy (CRT) devices, according to the recommendations of the European Society of Cardiology at the beginning of the study. Patients were followed for one year according to the practice of each center. Results: A total of 486 patients were included in the registry, half of whom received an ICD and the other half a CRT pacemaker (CRT‐P) or CRT defibrillator (CRT‐D). Mean age was 65±12 years and the most frequent causes of HF were ischemic (47{\%}) and idiopathic dilated cardiomyopathy (28{\%}). Overall mortality at one year was 3.6{\%} and the hospitalization rate was 11{\%}, significantly higher in patients with CRT‐P/CRT‐D than with ICD (17{\%} vs. 5.6{\%}, p<0.001). Patients who received CRT‐P/CRT‐D experienced significant reductions in QRS duration (160±21 vs. 141±24 ms, p<0.001) as well as improvement in New York Heart Association functional class. Conclusion: The S{\'i}ncrone study shows that the use of implantable devices in HF with reduced LVEF in Portugal is in accordance with international recommendations and that patients presented functional improvement and reduced one‐year mortality.",
keywords = "Heart failure, Hospitalization, Implantable cardiac devices, Mortality, Reduced left ventricular ejection fraction, Resynchronization",
author = "Daniel Bonhorst and Sara Guerreiro and C{\^a}ndida Fonseca and Nuno Cardim and Filipe Macedo and Pedro Adrag{\~a}o",
year = "2019",
month = "1",
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language = "Portuguese",
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journal = "Revista Portuguesa de Cardiologia",
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}

Implantação de dispositivos de ressincronização e/ou desfibrilhação em doentes com insuficiência cardíaca : dados da vida real ‐ o Estudo Síncrone. / Bonhorst, Daniel; Guerreiro, Sara; Fonseca, Cândida; Cardim, Nuno; Macedo, Filipe; Adragão, Pedro.

In: Revista Portuguesa de Cardiologia, Vol. 38, No. 1, 01.2019, p. 33-41.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Implantação de dispositivos de ressincronização e/ou desfibrilhação em doentes com insuficiência cardíaca

T2 - dados da vida real ‐ o Estudo Síncrone

AU - Bonhorst, Daniel

AU - Guerreiro, Sara

AU - Fonseca, Cândida

AU - Cardim, Nuno

AU - Macedo, Filipe

AU - Adragão, Pedro

PY - 2019/1

Y1 - 2019/1

N2 - Introduction: The aim of this study was to document clinical practice in Portugal regarding the use of electronic cardiac devices in patients with heart failure (HF) and reduced left ventricular ejection fraction (LVEF). Methods: The Síncrone study was an observational prospective multicenter registry conducted in 16 centers in Portugal between 2006 and 2014. It included adult patients with a diagnosis of HF, LVEF <35% and indication for implantable cardioverter‐defibrillator (ICD) and/or cardiac resynchronization therapy (CRT) devices, according to the recommendations of the European Society of Cardiology at the beginning of the study. Patients were followed for one year according to the practice of each center. Results: A total of 486 patients were included in the registry, half of whom received an ICD and the other half a CRT pacemaker (CRT‐P) or CRT defibrillator (CRT‐D). Mean age was 65±12 years and the most frequent causes of HF were ischemic (47%) and idiopathic dilated cardiomyopathy (28%). Overall mortality at one year was 3.6% and the hospitalization rate was 11%, significantly higher in patients with CRT‐P/CRT‐D than with ICD (17% vs. 5.6%, p<0.001). Patients who received CRT‐P/CRT‐D experienced significant reductions in QRS duration (160±21 vs. 141±24 ms, p<0.001) as well as improvement in New York Heart Association functional class. Conclusion: The Síncrone study shows that the use of implantable devices in HF with reduced LVEF in Portugal is in accordance with international recommendations and that patients presented functional improvement and reduced one‐year mortality.

AB - Introduction: The aim of this study was to document clinical practice in Portugal regarding the use of electronic cardiac devices in patients with heart failure (HF) and reduced left ventricular ejection fraction (LVEF). Methods: The Síncrone study was an observational prospective multicenter registry conducted in 16 centers in Portugal between 2006 and 2014. It included adult patients with a diagnosis of HF, LVEF <35% and indication for implantable cardioverter‐defibrillator (ICD) and/or cardiac resynchronization therapy (CRT) devices, according to the recommendations of the European Society of Cardiology at the beginning of the study. Patients were followed for one year according to the practice of each center. Results: A total of 486 patients were included in the registry, half of whom received an ICD and the other half a CRT pacemaker (CRT‐P) or CRT defibrillator (CRT‐D). Mean age was 65±12 years and the most frequent causes of HF were ischemic (47%) and idiopathic dilated cardiomyopathy (28%). Overall mortality at one year was 3.6% and the hospitalization rate was 11%, significantly higher in patients with CRT‐P/CRT‐D than with ICD (17% vs. 5.6%, p<0.001). Patients who received CRT‐P/CRT‐D experienced significant reductions in QRS duration (160±21 vs. 141±24 ms, p<0.001) as well as improvement in New York Heart Association functional class. Conclusion: The Síncrone study shows that the use of implantable devices in HF with reduced LVEF in Portugal is in accordance with international recommendations and that patients presented functional improvement and reduced one‐year mortality.

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KW - Implantable cardiac devices

KW - Mortality

KW - Reduced left ventricular ejection fraction

KW - Resynchronization

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