Real-world evidence from a European cohort study of patients with treatment resistant depression: Baseline patient characteristics: Patient characteristics in treatment resistant depression

K. Heerlein, A. H. Young, C. Otte, T. Frodl, G. Degraeve, W. Hagedoorn, A. J. Oliveira-Maia, V. Perez Sola, S. Rathod, G. Rosso, P. Sierra, J. Morrens, G. Van Dooren, Y. Gali, G. Perugi

Research output: Contribution to journalArticle

Abstract

Background: Treatment resistant depression (TRD; failure to respond to ≥2 treatments) affects ~20% of patients with major depressive disorder (MDD). Real-world data could help describe patient characteristics and TRD disease burden, to assess the unmet needs of TRD patients in Europe. Methods: This observational study collected data from adults with moderate to severe TRD initiating a new treatment for depression, according to local standards of care. At baseline, socio-demographic characteristics, medical history, prior and current treatments were recorded. Disease severity, health-related quality of life (HRQoL), functionality and productivity were assessed. Results: Overall, 411 eligible patients were enrolled across seven European countries. Mean (standard deviation [SD]) patient age was 51.0 (10.8) years; 62.3% were female. Long-term sick leave was reported by 19.0% of patients; 30.2% were unemployed. The mean (SD) duration of the current episode was 2.6 (3.9) years. At baseline, mean (SD) HRQoL scores for EuroQoL 5-dimension 5-level (UK tariff) and EQ-Visual Analog Scale were 0.41 (0.25) and 41.1 (18.7), respectively. The Work Productivity and Activity Impairment questionnaire demonstrated mean (SD) absenteeism of 57.0% (44.9%) and presenteeism of 54.7% (29.5%); mean (SD) overall work impairment was 60.5% (29.9%). Limitations: Key limitations are small cohort size, absence of a control group and generalizability to countries with different healthcare models. Conclusions: TRD patients had a high disease burden, low HRQoL and reduced function and productivity, with a substantial proportion unable to work. This demonstrates an unmet treatment need in TRD patients that, if addressed, could reduce the heavy personal and societal burden.

Original languageEnglish
Pages (from-to)115-122
Number of pages8
JournalJournal of Affective Disorders
Volume283
DOIs
Publication statusPublished - 15 Mar 2021

Keywords

  • Disease burden
  • Health-related quality of life
  • Major depressive disorder
  • Observational study
  • Patient-reported outcomes
  • Socio-economic status

Fingerprint Dive into the research topics of 'Real-world evidence from a European cohort study of patients with treatment resistant depression: Baseline patient characteristics: Patient characteristics in treatment resistant depression'. Together they form a unique fingerprint.

Cite this