Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia

Kim Oren Gradel, Pedro Póvoa, Pernille Just Vinholt, Bjarne Magnussen, Court Pedersen, Thøger Gorm Jensen, Hans Jørn Kolmos, Annmarie Touborg Lassen

Research output: Contribution to journalArticle

Abstract

AIM: To assess trajectory patterns of C-reactive protein (CRP) and plasma albumin (PA) levels around bacteremia.

PATIENTS & METHODS: Population-based study, 2418 community-acquired bacteremia patients, CRP and PA specimens from 30 days before through 30 days after bacteremia (day 0). A pattern was based on specimen occurring or not in days -30/-1, 0, 1/7 or 8/30. Mean daily CRP and PA levels on day -30/30 were computed for pattern subgroups.

RESULTS & CONCLUSION: Mean CRP rose on day -5 and reached its peak on day 1. Mean steady PA on day -30/0 declined abruptly on day 1, increasing slowly thereafter. Trajectories did not differ between subgroups. We conclude that longitudinal analysis results can be extrapolated to all community-acquired bacteremia patients.

Original languageEnglish
Pages (from-to)1251-1259
JournalBiomarkers in medicine
Volume12
Issue number11
DOIs
Publication statusPublished - 30 Nov 2018

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Bacteremia
Serum Albumin
C-Reactive Protein
Albumins
Population

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Gradel, K. O., Póvoa, P., Vinholt, P. J., Magnussen, B., Pedersen, C., Jensen, T. G., ... Lassen, A. T. (2018). Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia. Biomarkers in medicine, 12(11), 1251-1259. https://doi.org/10.2217/bmm-2018-0043
Gradel, Kim Oren ; Póvoa, Pedro ; Vinholt, Pernille Just ; Magnussen, Bjarne ; Pedersen, Court ; Jensen, Thøger Gorm ; Kolmos, Hans Jørn ; Lassen, Annmarie Touborg. / Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia. In: Biomarkers in medicine. 2018 ; Vol. 12, No. 11. pp. 1251-1259.
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Gradel, KO, Póvoa, P, Vinholt, PJ, Magnussen, B, Pedersen, C, Jensen, TG, Kolmos, HJ & Lassen, AT 2018, 'Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia', Biomarkers in medicine, vol. 12, no. 11, pp. 1251-1259. https://doi.org/10.2217/bmm-2018-0043

Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia. / Gradel, Kim Oren; Póvoa, Pedro; Vinholt, Pernille Just; Magnussen, Bjarne; Pedersen, Court; Jensen, Thøger Gorm; Kolmos, Hans Jørn; Lassen, Annmarie Touborg.

In: Biomarkers in medicine, Vol. 12, No. 11, 30.11.2018, p. 1251-1259.

Research output: Contribution to journalArticle

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T1 - Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia

AU - Gradel, Kim Oren

AU - Póvoa, Pedro

AU - Vinholt, Pernille Just

AU - Magnussen, Bjarne

AU - Pedersen, Court

AU - Jensen, Thøger Gorm

AU - Kolmos, Hans Jørn

AU - Lassen, Annmarie Touborg

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AB - AIM: To assess trajectory patterns of C-reactive protein (CRP) and plasma albumin (PA) levels around bacteremia.PATIENTS & METHODS: Population-based study, 2418 community-acquired bacteremia patients, CRP and PA specimens from 30 days before through 30 days after bacteremia (day 0). A pattern was based on specimen occurring or not in days -30/-1, 0, 1/7 or 8/30. Mean daily CRP and PA levels on day -30/30 were computed for pattern subgroups.RESULTS & CONCLUSION: Mean CRP rose on day -5 and reached its peak on day 1. Mean steady PA on day -30/0 declined abruptly on day 1, increasing slowly thereafter. Trajectories did not differ between subgroups. We conclude that longitudinal analysis results can be extrapolated to all community-acquired bacteremia patients.

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