Rapid stoichiometric analysis of G-quadruplexes in solution

Patrick David Groves

doi:10.1002/chem.200901248

Rapid stoichiometric analysis of G-quadruplexes in solution

Patrick David Groves

Instituto de Tecnologia Química e Biológica António Xavier (ITQB)

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Spectroscopy on a G-string! Currently there is strong interest in the determination of the topology of nucleic acid G-quadruplexes due to their biotechnological potential and biological significance. This requires the evaluation of the strand oligomerization level. Here we demonstrate a method for routine assessment of the stoichiometry of nucleic acid quadruplexes in aqueous solutions.

Original language	Unknown
Pages (from-to)	6451-6453
Journal	Chemistry - A European Journal
Volume	16
Issue number	22
DOIs	https://doi.org/10.1002/chem.200901248
Publication status	Published - 1 Jan 2010

Access to Document

10.1002/chem.200901248

Cite this

@article{f8eb1a1df16b4811913b2f8cf87e5298,

title = "Rapid stoichiometric analysis of G-quadruplexes in solution",

abstract = "Spectroscopy on a G-string! Currently there is strong interest in the determination of the topology of nucleic acid G-quadruplexes due to their biotechnological potential and biological significance. This requires the evaluation of the strand oligomerization level. Here we demonstrate a method for routine assessment of the stoichiometry of nucleic acid quadruplexes in aqueous solutions.",

keywords = "KINETICS, MAGNETIC-RESONANCE-SPECTROSCOPY, SEQUENCE FORMS, POTASSIUM, STRANDS, NMR, DIFFUSION-ORDERED SPECTROSCOPY",

author = "Groves, {Patrick David}",

year = "2010",

month = jan,

day = "1",

doi = "10.1002/chem.200901248",

language = "Unknown",

volume = "16",

pages = "6451--6453",

journal = "Chemistry - A European Journal",

issn = "0947-6539",

publisher = "Wiley",

number = "22",

}

TY - JOUR

T1 - Rapid stoichiometric analysis of G-quadruplexes in solution

AU - Groves, Patrick David

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Spectroscopy on a G-string! Currently there is strong interest in the determination of the topology of nucleic acid G-quadruplexes due to their biotechnological potential and biological significance. This requires the evaluation of the strand oligomerization level. Here we demonstrate a method for routine assessment of the stoichiometry of nucleic acid quadruplexes in aqueous solutions.

AB - Spectroscopy on a G-string! Currently there is strong interest in the determination of the topology of nucleic acid G-quadruplexes due to their biotechnological potential and biological significance. This requires the evaluation of the strand oligomerization level. Here we demonstrate a method for routine assessment of the stoichiometry of nucleic acid quadruplexes in aqueous solutions.

KW - KINETICS

KW - MAGNETIC-RESONANCE-SPECTROSCOPY

KW - SEQUENCE FORMS

KW - POTASSIUM

KW - STRANDS

KW - NMR

KW - DIFFUSION-ORDERED SPECTROSCOPY

U2 - 10.1002/chem.200901248

DO - 10.1002/chem.200901248

M3 - Article

VL - 16

SP - 6451

EP - 6453

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

IS - 22

ER -