Radiofrequency echographic multi-spectrometry for the in-vivo assessment of bone strength

state of the art—outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)

Adolfo Diez-Perez, Maria Luisa Brandi, Nasser Al-Daghri, Jaime C. Branco, Olivier Bruyère, Loredana Cavalli, Cyrus Cooper, Bernard Cortet, Bess Dawson-Hughes, Hans Peter Dimai, Stefano Gonnelli, Peyman Hadji, Philippe Halbout, Jean Marc Kaufman, Andreas Kurth, Medea Locquet, Stefania Maggi, Radmila Matijevic, Jean Yves Reginster, René Rizzoli & 1 others Thomas Thierry

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Abstract

Purpose: The purpose of this paper was to review the available approaches for bone strength assessment, osteoporosis diagnosis and fracture risk prediction, and to provide insights into radiofrequency echographic multi spectrometry (REMS), a non-ionizing axial skeleton technique. Methods: A working group convened by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis met to review the current image-based methods for bone strength assessment and fracture risk estimation, and to discuss the clinical perspectives of REMS. Results: Areal bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is the consolidated indicator for osteoporosis diagnosis and fracture risk assessment. A more reliable fracture risk estimation would actually require an improved assessment of bone strength, integrating also bone quality information. Several different approaches have been proposed, including additional DXA-based parameters, quantitative computed tomography, and quantitative ultrasound. Although each of them showed a somewhat improved clinical performance, none satisfied all the requirements for a widespread routine employment, which was typically hindered by unclear clinical usefulness, radiation doses, limited accessibility, or inapplicability to spine and hip, therefore leaving several clinical needs still unmet. REMS is a clinically available technology for osteoporosis diagnosis and fracture risk assessment through the estimation of BMD on the axial skeleton reference sites. Its automatic processing of unfiltered ultrasound signals provides accurate BMD values in view of fracture risk assessment. Conclusions: New approaches for improved bone strength and fracture risk estimations are needed for a better management of osteoporotic patients. In this context, REMS represents a valuable approach for osteoporosis diagnosis and fracture risk prediction.

Original languageEnglish
Pages (from-to)1375-1389
JournalAging Clinical and Experimental Research
Volume31
Issue number10
DOIs
Publication statusPublished - Oct 2019

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Musculoskeletal Diseases
Osteoarthritis
Osteoporosis
Spectrum Analysis
Economics
Bone Density
Bone and Bones
Photon Absorptiometry
Skeleton
Bone Fractures
Hip
Spine
Tomography
Radiation
Technology

Keywords

  • Bone strength assessment
  • Femoral neck
  • Fracture risk
  • Lumbar spine
  • Osteoporosis diagnosis
  • REMS
  • Ultrasound

Cite this

Diez-Perez, Adolfo ; Brandi, Maria Luisa ; Al-Daghri, Nasser ; Branco, Jaime C. ; Bruyère, Olivier ; Cavalli, Loredana ; Cooper, Cyrus ; Cortet, Bernard ; Dawson-Hughes, Bess ; Dimai, Hans Peter ; Gonnelli, Stefano ; Hadji, Peyman ; Halbout, Philippe ; Kaufman, Jean Marc ; Kurth, Andreas ; Locquet, Medea ; Maggi, Stefania ; Matijevic, Radmila ; Reginster, Jean Yves ; Rizzoli, René ; Thierry, Thomas. / Radiofrequency echographic multi-spectrometry for the in-vivo assessment of bone strength : state of the art—outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). In: Aging Clinical and Experimental Research. 2019 ; Vol. 31, No. 10. pp. 1375-1389.
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title = "Radiofrequency echographic multi-spectrometry for the in-vivo assessment of bone strength: state of the art—outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)",
abstract = "Purpose: The purpose of this paper was to review the available approaches for bone strength assessment, osteoporosis diagnosis and fracture risk prediction, and to provide insights into radiofrequency echographic multi spectrometry (REMS), a non-ionizing axial skeleton technique. Methods: A working group convened by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis met to review the current image-based methods for bone strength assessment and fracture risk estimation, and to discuss the clinical perspectives of REMS. Results: Areal bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is the consolidated indicator for osteoporosis diagnosis and fracture risk assessment. A more reliable fracture risk estimation would actually require an improved assessment of bone strength, integrating also bone quality information. Several different approaches have been proposed, including additional DXA-based parameters, quantitative computed tomography, and quantitative ultrasound. Although each of them showed a somewhat improved clinical performance, none satisfied all the requirements for a widespread routine employment, which was typically hindered by unclear clinical usefulness, radiation doses, limited accessibility, or inapplicability to spine and hip, therefore leaving several clinical needs still unmet. REMS is a clinically available technology for osteoporosis diagnosis and fracture risk assessment through the estimation of BMD on the axial skeleton reference sites. Its automatic processing of unfiltered ultrasound signals provides accurate BMD values in view of fracture risk assessment. Conclusions: New approaches for improved bone strength and fracture risk estimations are needed for a better management of osteoporotic patients. In this context, REMS represents a valuable approach for osteoporosis diagnosis and fracture risk prediction.",
keywords = "Bone strength assessment, Femoral neck, Fracture risk, Lumbar spine, Osteoporosis diagnosis, REMS, Ultrasound",
author = "Adolfo Diez-Perez and Brandi, {Maria Luisa} and Nasser Al-Daghri and Branco, {Jaime C.} and Olivier Bruy{\`e}re and Loredana Cavalli and Cyrus Cooper and Bernard Cortet and Bess Dawson-Hughes and Dimai, {Hans Peter} and Stefano Gonnelli and Peyman Hadji and Philippe Halbout and Kaufman, {Jean Marc} and Andreas Kurth and Medea Locquet and Stefania Maggi and Radmila Matijevic and Reginster, {Jean Yves} and Ren{\'e} Rizzoli and Thomas Thierry",
year = "2019",
month = "10",
doi = "10.1007/s40520-019-01294-4",
language = "English",
volume = "31",
pages = "1375--1389",
journal = "Aging Clinical and Experimental Research",
issn = "1594-0667",
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Diez-Perez, A, Brandi, ML, Al-Daghri, N, Branco, JC, Bruyère, O, Cavalli, L, Cooper, C, Cortet, B, Dawson-Hughes, B, Dimai, HP, Gonnelli, S, Hadji, P, Halbout, P, Kaufman, JM, Kurth, A, Locquet, M, Maggi, S, Matijevic, R, Reginster, JY, Rizzoli, R & Thierry, T 2019, 'Radiofrequency echographic multi-spectrometry for the in-vivo assessment of bone strength: state of the art—outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)', Aging Clinical and Experimental Research, vol. 31, no. 10, pp. 1375-1389. https://doi.org/10.1007/s40520-019-01294-4

Radiofrequency echographic multi-spectrometry for the in-vivo assessment of bone strength : state of the art—outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). / Diez-Perez, Adolfo; Brandi, Maria Luisa; Al-Daghri, Nasser; Branco, Jaime C.; Bruyère, Olivier; Cavalli, Loredana; Cooper, Cyrus; Cortet, Bernard; Dawson-Hughes, Bess; Dimai, Hans Peter; Gonnelli, Stefano; Hadji, Peyman; Halbout, Philippe; Kaufman, Jean Marc; Kurth, Andreas; Locquet, Medea; Maggi, Stefania; Matijevic, Radmila; Reginster, Jean Yves; Rizzoli, René; Thierry, Thomas.

In: Aging Clinical and Experimental Research, Vol. 31, No. 10, 10.2019, p. 1375-1389.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Radiofrequency echographic multi-spectrometry for the in-vivo assessment of bone strength

T2 - state of the art—outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)

AU - Diez-Perez, Adolfo

AU - Brandi, Maria Luisa

AU - Al-Daghri, Nasser

AU - Branco, Jaime C.

AU - Bruyère, Olivier

AU - Cavalli, Loredana

AU - Cooper, Cyrus

AU - Cortet, Bernard

AU - Dawson-Hughes, Bess

AU - Dimai, Hans Peter

AU - Gonnelli, Stefano

AU - Hadji, Peyman

AU - Halbout, Philippe

AU - Kaufman, Jean Marc

AU - Kurth, Andreas

AU - Locquet, Medea

AU - Maggi, Stefania

AU - Matijevic, Radmila

AU - Reginster, Jean Yves

AU - Rizzoli, René

AU - Thierry, Thomas

PY - 2019/10

Y1 - 2019/10

N2 - Purpose: The purpose of this paper was to review the available approaches for bone strength assessment, osteoporosis diagnosis and fracture risk prediction, and to provide insights into radiofrequency echographic multi spectrometry (REMS), a non-ionizing axial skeleton technique. Methods: A working group convened by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis met to review the current image-based methods for bone strength assessment and fracture risk estimation, and to discuss the clinical perspectives of REMS. Results: Areal bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is the consolidated indicator for osteoporosis diagnosis and fracture risk assessment. A more reliable fracture risk estimation would actually require an improved assessment of bone strength, integrating also bone quality information. Several different approaches have been proposed, including additional DXA-based parameters, quantitative computed tomography, and quantitative ultrasound. Although each of them showed a somewhat improved clinical performance, none satisfied all the requirements for a widespread routine employment, which was typically hindered by unclear clinical usefulness, radiation doses, limited accessibility, or inapplicability to spine and hip, therefore leaving several clinical needs still unmet. REMS is a clinically available technology for osteoporosis diagnosis and fracture risk assessment through the estimation of BMD on the axial skeleton reference sites. Its automatic processing of unfiltered ultrasound signals provides accurate BMD values in view of fracture risk assessment. Conclusions: New approaches for improved bone strength and fracture risk estimations are needed for a better management of osteoporotic patients. In this context, REMS represents a valuable approach for osteoporosis diagnosis and fracture risk prediction.

AB - Purpose: The purpose of this paper was to review the available approaches for bone strength assessment, osteoporosis diagnosis and fracture risk prediction, and to provide insights into radiofrequency echographic multi spectrometry (REMS), a non-ionizing axial skeleton technique. Methods: A working group convened by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis met to review the current image-based methods for bone strength assessment and fracture risk estimation, and to discuss the clinical perspectives of REMS. Results: Areal bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is the consolidated indicator for osteoporosis diagnosis and fracture risk assessment. A more reliable fracture risk estimation would actually require an improved assessment of bone strength, integrating also bone quality information. Several different approaches have been proposed, including additional DXA-based parameters, quantitative computed tomography, and quantitative ultrasound. Although each of them showed a somewhat improved clinical performance, none satisfied all the requirements for a widespread routine employment, which was typically hindered by unclear clinical usefulness, radiation doses, limited accessibility, or inapplicability to spine and hip, therefore leaving several clinical needs still unmet. REMS is a clinically available technology for osteoporosis diagnosis and fracture risk assessment through the estimation of BMD on the axial skeleton reference sites. Its automatic processing of unfiltered ultrasound signals provides accurate BMD values in view of fracture risk assessment. Conclusions: New approaches for improved bone strength and fracture risk estimations are needed for a better management of osteoporotic patients. In this context, REMS represents a valuable approach for osteoporosis diagnosis and fracture risk prediction.

KW - Bone strength assessment

KW - Femoral neck

KW - Fracture risk

KW - Lumbar spine

KW - Osteoporosis diagnosis

KW - REMS

KW - Ultrasound

UR - http://www.scopus.com/inward/record.url?scp=85071092064&partnerID=8YFLogxK

U2 - 10.1007/s40520-019-01294-4

DO - 10.1007/s40520-019-01294-4

M3 - Review article

VL - 31

SP - 1375

EP - 1389

JO - Aging Clinical and Experimental Research

JF - Aging Clinical and Experimental Research

SN - 1594-0667

IS - 10

ER -