Rab27a and melanosomes: A model to investigate the membrane targeting of Rabs

Antonia E.G. Booth; Miguel C. Seabra; Alistair N. Hume

doi:10.1042/BST20120200

Rab27a and melanosomes: A model to investigate the membrane targeting of Rabs

Antonia E.G. Booth, Miguel C. Seabra, Alistair N. Hume

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Rab proteins constitute the largest family within the Ras superfamily of small GTPases (>60 in mammals) and are essential regulators of transport between intracellular organelles. Key to this activity is their targeting to specific compartments within the cell. However, although great strides have been made over the last 25 years in assigning functions to individual Rabs and identifying their downstream effectors, the mechanism(s) regulating their targeting to specific subcellular membranes remains less well understood. In the present paper, we review the evidence supporting the proposed mechanisms of Rab targeting and highlight insights into this process provided by studies of Rab27a.

Original language	English
Pages (from-to)	1383-1388
Number of pages	6
Journal	Biochemical Society Transactions
Volume	40
Issue number	6
DOIs	https://doi.org/10.1042/BST20120200
Publication status	Published - Dec 2012

Keywords

Melanocyte
Melanosomes
Rab GTPase
Rab27a

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10.1042/BST20120200

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Rab27a and melanosomes: A model to investigate the membrane targeting of Rabs

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Keywords

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