TY - JOUR
T1 - Quinoxaline, its derivatives and biological applications: A state of the art review
AU - Pereira, Joana A.
AU - Pessoa, Ana M.
AU - Cordeiro, M. Natália D. S.
AU - Fernandes, Ruben M.
AU - Prudêncio, Cristina
AU - Noronha, João Paulo da Costa de
AU - Vieira, Mónica A. A.
N1 - SCOPUSID:84937484699
PMID:25011559
PY - 2015/6/5
Y1 - 2015/6/5
N2 - Quinoxaline derivatives are an important class of heterocycle compounds, where N replaces some carbon atoms in the ring of naphthalene. Its molecular formula is C8H6N2, formed by the fusion of two aromatic rings, benzene and pyrazine. It is rare in natural state, but their synthesis is easy to perform. In this review the State of the Art will be presented, which includes a summary of the progress made over the past years in the knowledge of the structure and mechanism of the quinoxaline and quinoxaline derivatives, associated medical and biomedical value as well as industrial value. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.
AB - Quinoxaline derivatives are an important class of heterocycle compounds, where N replaces some carbon atoms in the ring of naphthalene. Its molecular formula is C8H6N2, formed by the fusion of two aromatic rings, benzene and pyrazine. It is rare in natural state, but their synthesis is easy to perform. In this review the State of the Art will be presented, which includes a summary of the progress made over the past years in the knowledge of the structure and mechanism of the quinoxaline and quinoxaline derivatives, associated medical and biomedical value as well as industrial value. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.
KW - Biological activity
KW - Biomedical applications
KW - Quinoxaline
KW - Quinoxaline derivatives
KW - Therapeutic application
U2 - 10.1016/j.ejmech.2014.06.058Quinoxaline
DO - 10.1016/j.ejmech.2014.06.058Quinoxaline
M3 - Literature review
C2 - 25011559
SN - 0223-5234
VL - 97
SP - 664
EP - 672
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
IS - 1
ER -