Quinoxaline derivatives are an important class of heterocycle compounds, where N replaces some carbon atoms in the ring of naphthalene. Its molecular formula is C8H6N2, formed by the fusion of two aromatic rings, benzene and pyrazine. It is rare in natural state, but their synthesis is easy to perform. In this review the State of the Art will be presented, which includes a summary of the progress made over the past years in the knowledge of the structure and mechanism of the quinoxaline and quinoxaline derivatives, associated medical and biomedical value as well as industrial value. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.
|Journal||European Journal of Medicinal Chemistry|
|Publication status||Published - 5 Jun 2015|
- Biological activity
- Biomedical applications
- Quinoxaline derivatives
- Therapeutic application
Pereira, J. A., Pessoa, A. M., Cordeiro, M. N. D. S., Fernandes, R. M., Prudêncio, C., Noronha, J. P. D. C. D., & Vieira, M. A. A. (2015). Quinoxaline, its derivatives and biological applications: A state of the art review. European Journal of Medicinal Chemistry, 97(1), 664-672. https://doi.org/10.1016/j.ejmech.2014.06.058Quinoxaline