Quercetin and the mutagenicity of wines

J. Gaspar, A. Laires, M. Monteiro, O. Laureano, E. Ramos

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Various studies have shown the mutagenicity of red wine. The major mutagens identified in red wine have been flavonoids, i.e. rutin and its aglycone quercetin. Besides flavonoids, however, it has recently been reported that H 2 O 2 may account for the mutagenicity of red wine in the L-Arabinose resistance test. In the present study we report on the role of flavonoids in the mutagenicity of red wine in the Ames assay. Different wines from Portugal and Spain have been tested after concentration in XAD-2 columns in strains TA98 and TA104 of Salmonella typhimurium concurrently with the determination of the respective content of quercetin by HPLC. A similar approach was used for pilot scale productions of red wines. In all cases quercetin could be demonstrated as the major mutagen in red wines. The levels of quercetin in finished wines and during the wine-making process showed a good fit with the levels of mutagenicity detected. Catalase had no effect whatsoever on the mutagenicity of wines in both TA98 and TA104. These results do not rule out a role for H 2 O 2 in the mutagenicity of wines, detected in other genetic end-points, because H 2 O 2 can be formed from the autooxidation of quercetin.

Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalMutagenesis
Volume8
Issue number1
DOIs
Publication statusPublished - 1 Jan 1993

Fingerprint

Wine
Quercetin
Flavonoids
Mutagens
Rutin
Arabinose
Salmonella
Portugal
Salmonella typhimurium
Spain
Catalase
Assays
High Pressure Liquid Chromatography

Cite this

Gaspar, J. ; Laires, A. ; Monteiro, M. ; Laureano, O. ; Ramos, E. / Quercetin and the mutagenicity of wines. In: Mutagenesis. 1993 ; Vol. 8, No. 1. pp. 51-55.
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Gaspar, J, Laires, A, Monteiro, M, Laureano, O & Ramos, E 1993, 'Quercetin and the mutagenicity of wines', Mutagenesis, vol. 8, no. 1, pp. 51-55. https://doi.org/10.1093/mutage/8.1.51

Quercetin and the mutagenicity of wines. / Gaspar, J.; Laires, A.; Monteiro, M.; Laureano, O.; Ramos, E.

In: Mutagenesis, Vol. 8, No. 1, 01.01.1993, p. 51-55.

Research output: Contribution to journalArticle

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