Quality of life in patients with cognitive impairment: validation of the Quality of Life-Alzheimer's Disease scale in Portugal

H Barrios; Ana Verdelho; Sofia Narciso; M Gonçalves-Pereira; Rebecca  Logsdon; Alexandre Mendonça

doi:10.1017/S1041610213000379

Quality of life in patients with cognitive impairment: validation of the Quality of Life-Alzheimer's Disease scale in Portugal

H Barrios, Ana Verdelho, Sofia Narciso, M Gonçalves-Pereira, Rebecca Logsdon, Alexandre Mendonça

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Background: Quality of Life-Alzheimer's Disease (QOL-AD) is a widely used scale for the study of quality of life in patients with dementia. The aim of this study is the transcultural adaptation and validation of the QOL-AD scale in Portugal. Methods: Translation and transcultural adaptation was performed according to state-of-the-art recommendations. For the validation study, 104 patient/caregiver pairs were enrolled. Patients had mild cognitive impairment or mild-to-moderate dementia (due to Alzheimer's disease or vascular dementia). Participants were recruited in a dementia outpatient clinic setting and a long-term care dementia ward. An additional comparison group of 22 patients without cognitive impairment, and their proxies, was recruited in a family practice outpatient clinic. Sociodemographic information on patients and caregivers was obtained. Acceptability, reliability, and construct validity were analyzed. Results: Internal consistency of the Portuguese version of QOL-AD was good for both patient and caregiver report (Cronbach's alpha = 0.867 and 0.858, respectively). Construct validity was confirmed by the correlation of patient reported QOL-AD with patient geriatric depression scale scores (rho = -0.702, p < 0.001) and satisfaction with life scale scores (rho = 0.543, p < 0.001). Caregiver ratings were correlated with neuropsychiatric inventory (NPI) total score (rho = -0.404, p < 0.001), NPI-distress (rho = -0.346, p < 0.001), and patient Mini-Mental State Examination (rho = 0.319, p < 0.01). QOL-AD patient ratings were higher than caregiver ratings (p < 0.001). Both patient-and caregiver-rated QOL-AD scores were lower in patients with cognitive impairment than in the comparison group without cognitive impairment (p < 0.01). Conclusions: A Portuguese version of QOL-AD with consistent psychometric properties was obtained and is proposed as a useful tool for research and clinical purposes.

Original language	English
Pages (from-to)	1085-1096
Journal	International psychogeriatrics / IPA
Volume	25
Issue number	7
DOIs	https://doi.org/10.1017/S1041610213000379
Publication status	Published - 2013

Access to Document

10.1017/S1041610213000379

Cite this

@article{0d010e9c3f0a40dc888e729ca61e886c,

title = "Quality of life in patients with cognitive impairment: validation of the Quality of Life-Alzheimer's Disease scale in Portugal",

abstract = "Background: Quality of Life-Alzheimer's Disease (QOL-AD) is a widely used scale for the study of quality of life in patients with dementia. The aim of this study is the transcultural adaptation and validation of the QOL-AD scale in Portugal. Methods: Translation and transcultural adaptation was performed according to state-of-the-art recommendations. For the validation study, 104 patient/caregiver pairs were enrolled. Patients had mild cognitive impairment or mild-to-moderate dementia (due to Alzheimer's disease or vascular dementia). Participants were recruited in a dementia outpatient clinic setting and a long-term care dementia ward. An additional comparison group of 22 patients without cognitive impairment, and their proxies, was recruited in a family practice outpatient clinic. Sociodemographic information on patients and caregivers was obtained. Acceptability, reliability, and construct validity were analyzed. Results: Internal consistency of the Portuguese version of QOL-AD was good for both patient and caregiver report (Cronbach's alpha = 0.867 and 0.858, respectively). Construct validity was confirmed by the correlation of patient reported QOL-AD with patient geriatric depression scale scores (rho = -0.702, p < 0.001) and satisfaction with life scale scores (rho = 0.543, p < 0.001). Caregiver ratings were correlated with neuropsychiatric inventory (NPI) total score (rho = -0.404, p < 0.001), NPI-distress (rho = -0.346, p < 0.001), and patient Mini-Mental State Examination (rho = 0.319, p < 0.01). QOL-AD patient ratings were higher than caregiver ratings (p < 0.001). Both patient-and caregiver-rated QOL-AD scores were lower in patients with cognitive impairment than in the comparison group without cognitive impairment (p < 0.01). Conclusions: A Portuguese version of QOL-AD with consistent psychometric properties was obtained and is proposed as a useful tool for research and clinical purposes.",

keywords = "validation, RATINGS, ADAPTATION, dementia, TASK-FORCE, QOL-AD, mild cognitive impairment, CAREGIVERS, CRITERIA, PEOPLE, HEALTH-STATUS, DEMENTIA, Alzheimer's disease, quality of life, VERSION",

author = "H Barrios and Ana Verdelho and Sofia Narciso and M Gon{\c c}alves-Pereira and Rebecca Logsdon and Alexandre Mendon{\c c}a",

note = "WOS:000321262200006",

year = "2013",

doi = "10.1017/S1041610213000379",

language = "English",

volume = "25",

pages = "1085--1096",

journal = "International psychogeriatrics / IPA",

issn = "1041-6102",

publisher = "Cambridge University Press",

number = "7",

}

TY - JOUR

T1 - Quality of life in patients with cognitive impairment: validation of the Quality of Life-Alzheimer's Disease scale in Portugal

AU - Barrios, H

AU - Verdelho, Ana

AU - Narciso, Sofia

AU - Gonçalves-Pereira, M

AU - Logsdon, Rebecca

AU - Mendonça, Alexandre

N1 - WOS:000321262200006

PY - 2013

Y1 - 2013

N2 - Background: Quality of Life-Alzheimer's Disease (QOL-AD) is a widely used scale for the study of quality of life in patients with dementia. The aim of this study is the transcultural adaptation and validation of the QOL-AD scale in Portugal. Methods: Translation and transcultural adaptation was performed according to state-of-the-art recommendations. For the validation study, 104 patient/caregiver pairs were enrolled. Patients had mild cognitive impairment or mild-to-moderate dementia (due to Alzheimer's disease or vascular dementia). Participants were recruited in a dementia outpatient clinic setting and a long-term care dementia ward. An additional comparison group of 22 patients without cognitive impairment, and their proxies, was recruited in a family practice outpatient clinic. Sociodemographic information on patients and caregivers was obtained. Acceptability, reliability, and construct validity were analyzed. Results: Internal consistency of the Portuguese version of QOL-AD was good for both patient and caregiver report (Cronbach's alpha = 0.867 and 0.858, respectively). Construct validity was confirmed by the correlation of patient reported QOL-AD with patient geriatric depression scale scores (rho = -0.702, p < 0.001) and satisfaction with life scale scores (rho = 0.543, p < 0.001). Caregiver ratings were correlated with neuropsychiatric inventory (NPI) total score (rho = -0.404, p < 0.001), NPI-distress (rho = -0.346, p < 0.001), and patient Mini-Mental State Examination (rho = 0.319, p < 0.01). QOL-AD patient ratings were higher than caregiver ratings (p < 0.001). Both patient-and caregiver-rated QOL-AD scores were lower in patients with cognitive impairment than in the comparison group without cognitive impairment (p < 0.01). Conclusions: A Portuguese version of QOL-AD with consistent psychometric properties was obtained and is proposed as a useful tool for research and clinical purposes.

AB - Background: Quality of Life-Alzheimer's Disease (QOL-AD) is a widely used scale for the study of quality of life in patients with dementia. The aim of this study is the transcultural adaptation and validation of the QOL-AD scale in Portugal. Methods: Translation and transcultural adaptation was performed according to state-of-the-art recommendations. For the validation study, 104 patient/caregiver pairs were enrolled. Patients had mild cognitive impairment or mild-to-moderate dementia (due to Alzheimer's disease or vascular dementia). Participants were recruited in a dementia outpatient clinic setting and a long-term care dementia ward. An additional comparison group of 22 patients without cognitive impairment, and their proxies, was recruited in a family practice outpatient clinic. Sociodemographic information on patients and caregivers was obtained. Acceptability, reliability, and construct validity were analyzed. Results: Internal consistency of the Portuguese version of QOL-AD was good for both patient and caregiver report (Cronbach's alpha = 0.867 and 0.858, respectively). Construct validity was confirmed by the correlation of patient reported QOL-AD with patient geriatric depression scale scores (rho = -0.702, p < 0.001) and satisfaction with life scale scores (rho = 0.543, p < 0.001). Caregiver ratings were correlated with neuropsychiatric inventory (NPI) total score (rho = -0.404, p < 0.001), NPI-distress (rho = -0.346, p < 0.001), and patient Mini-Mental State Examination (rho = 0.319, p < 0.01). QOL-AD patient ratings were higher than caregiver ratings (p < 0.001). Both patient-and caregiver-rated QOL-AD scores were lower in patients with cognitive impairment than in the comparison group without cognitive impairment (p < 0.01). Conclusions: A Portuguese version of QOL-AD with consistent psychometric properties was obtained and is proposed as a useful tool for research and clinical purposes.

KW - validation

KW - RATINGS

KW - ADAPTATION

KW - dementia

KW - TASK-FORCE

KW - QOL-AD

KW - mild cognitive impairment

KW - CAREGIVERS

KW - CRITERIA

KW - PEOPLE

KW - HEALTH-STATUS

KW - DEMENTIA

KW - Alzheimer's disease

KW - quality of life

KW - VERSION

U2 - 10.1017/S1041610213000379

DO - 10.1017/S1041610213000379

M3 - Article

C2 - 23534370

SN - 1041-6102

VL - 25

SP - 1085

EP - 1096

JO - International psychogeriatrics / IPA

JF - International psychogeriatrics / IPA

IS - 7

ER -

Quality of life in patients with cognitive impairment: validation of the Quality of Life-Alzheimer's Disease scale in Portugal

Abstract

Access to Document

Fingerprint

Cite this