TY - JOUR
T1 - Pure polyphenols applications for cardiac health and disease
AU - Santos, Claudia N
AU - Gomes, Andreia
AU - Oudot, Carole
AU - Dias-Pedroso, Daniela
AU - Rodriguez-Mateos, Ana
AU - Vieira, Helena L A
AU - Brenner, Catherine
N1 - Copyright© Bentham Science Publishers; For any queries, please email at [email protected].
PY - 2018
Y1 - 2018
N2 - Polyphenols are natural compounds present in fruits and vegetables that can exert beneficial effects on human health and notably, on the cardiovascular system. Some of these compounds showed significant protective activities toward atherosclerosis, hypertension, myocardial infarction, anthracyclin-induced cardiomyopathy, angiogenesis as well as heart failure. Polyphenols can act through systemic effects as well as through modulation of signaling pathways such as redox signaling, inflammation, autophagy and cell death in the heart and vessels. These effects can be mediated by changes in expression level and by post-translational modifications of proteins (e.g. Stat1, CaMKII, Sirtuins, BCL-2 family members, PDEs, TRF2, eNOS and SOD). This non-comprehensive short review aims to summarize recent knowledge on the main pharmacological effects and mechanisms of cardioprotection of pure polyphenols, using different approaches such as cell culture, animal models and human studies.
AB - Polyphenols are natural compounds present in fruits and vegetables that can exert beneficial effects on human health and notably, on the cardiovascular system. Some of these compounds showed significant protective activities toward atherosclerosis, hypertension, myocardial infarction, anthracyclin-induced cardiomyopathy, angiogenesis as well as heart failure. Polyphenols can act through systemic effects as well as through modulation of signaling pathways such as redox signaling, inflammation, autophagy and cell death in the heart and vessels. These effects can be mediated by changes in expression level and by post-translational modifications of proteins (e.g. Stat1, CaMKII, Sirtuins, BCL-2 family members, PDEs, TRF2, eNOS and SOD). This non-comprehensive short review aims to summarize recent knowledge on the main pharmacological effects and mechanisms of cardioprotection of pure polyphenols, using different approaches such as cell culture, animal models and human studies.
KW - cardiac health
U2 - 10.2174/1381612824666180608102344
DO - 10.2174/1381612824666180608102344
M3 - Article
C2 - 29879878
SN - 1381-6128
VL - 24
SP - 2137
EP - 2156
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
IS - 19
ER -