We present the case of a 64 year old woman who, in the past 5 years, complained of constipation/diarrhea, hyposudoresis, xerostomy and xerophtalmia, disuria and orthostatic hypotension. Cardiovascular reflexes analysis revealed sympathetic and parasympathetic failure. Norepinephrine was markedly reduced, both lying and after tilt. Norepinephrine infusion determined a significant rise in blood pressure, allowing the diagnosis of denervation hypersensitivity. The diagnosis of Pure Autonomic Failure was made. Therapy with 9 alpha fludrocortisone and metoclopramide was initiated with marked and sustained symptomatic effect.
|Number of pages||5|
|Journal||Acta medica portuguesa|
|Publication status||Published - 1 Dec 1993|