Proton pathways, ligand binding and dynamics of the catalytic site in haem-copper oxygen reductases

A comparison between the three families

Research output: Contribution to journalReview article

34 Citations (Scopus)


Haem-copper oxygen reductases are the widest spread enzymes involved in aerobic respiratory chains, in Eukarya, Bacteria and Archaea. However, both the catalytic mechanism for oxygen reduction and its coupling to proton translocation remain to be fully understood. In this article we analyse the experimental data gathered in recent years for haem-copper reductases presenting features distinct from the mitochondrial-like enzymes. These features further support the classification of several families of haem-copper oxygen reductases based on their proton pathways and previously proposed by us [Biochim. Biophys. Acta 1505 (2001) 185], and allow to identify the minimal essential elements for these enzymes.

Original languageEnglish
Pages (from-to)340-346
Number of pages7
JournalBiochimica et Biophysica Acta - Bioenergetics
Issue number1-3
Publication statusPublished - 12 Apr 2004



  • Binuclear site
  • Cytochrome oxidase
  • Proton channel

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