@inbook{b94280af4d7d456d9614e3a89459d936,
title = "Proteomics in the assessment of the therapeutic response of antineoplastic drugs: Strategies and practical applications",
abstract = "Uncovering unknown pathological mechanisms and body response to applied medication are the driving forces toward personalized medicine. In this post-genomic era, all eyes are turned to the proteomics field, searching for answers and explanations by investigating the gene end point functional units—proteins and their proteoforms. The development of cutting-edge mass spectrometric technologies and bioinformatics tools have allowed the life- science community to discover disease-specific proteins as biomarkers, which are often concealed by high sample complexity and dynamic range of abundance. Currently, there are several proteomics-based approaches to investigate the proteome. This chapter focuses on gold standard proteomics strategies and related issues toward candidate biomarker discovery, which may have diagnostic/ prognostic as well as mechanistic utility in cancer drug resistance.",
keywords = "Cancer, Chemotherapeutic response, Discovery-based proteomics, Proteomics, Targetproteomics",
author = "Torres, {Vukosava Milic} and Lazar Popovic and F{\'a}tima Vaz and Deborah Penque",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media New York 2016. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",
year = "2016",
month = may,
day = "1",
doi = "10.1007/978-1-4939-3347-1_16",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press",
pages = "281--298",
booktitle = "Methods in Molecular Biology",
address = "United States",
}
