Protein- and Peptide-Based Biosensors in Artificial Olfaction

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Animals' olfactory systems rely on proteins, olfactory receptors (ORs) and odorant-binding proteins (OBPs), as their native sensing units to detect odours. Recent advances demonstrate that these proteins can also be employed as molecular recognition units in gas-phase biosensors. In addition, the interactions between odorant molecules and ORs or OBPs are a source of inspiration for designing peptides with tunable odorant selectivity. We review recent progress in gas biosensors employing biological units (ORs, OBPs, and peptides) in light of future developments in artificial olfaction, emphasizing examples where biological components have been employed to detect gas-phase analytes.

Original languageEnglish
Pages (from-to)1244-1258
Number of pages15
JournalTrends In Biotechnology
Issue number12
Publication statusPublished - 1 Dec 2018


  • artificial olfaction
  • biosensor
  • odorant-binding protein
  • olfactory receptor
  • peptide
  • Volatile organic compounds


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