TY - JOUR
T1 - Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat
AU - Figueira, Maria Eduardo
AU - Oliveira, Mónica
AU - Direito, Rosa
AU - Rocha, João
AU - Alves, Paula
AU - Serra, Ana Teresa
AU - Duarte, Catarina
AU - Bronze, Rosário
AU - Fernandes, Adelaide
AU - Brites, Dora
AU - Freitas, Marisa
AU - Fernandes, Eduarda
AU - Sepodes, Bruno
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Here we investigated the anti-inflammatory effect of a blueberry extract in the carrageenan-induced paw edema model and collagen-induced arthritis model, both in rats. Along with the chemical characterization of the phenolic content of the fruits and extract, the antioxidant potential of the extract, the cellular antioxidant activity and the effects over neutrophils’ oxidative burst, were studied in order to provide a mechanistic insight for the anti-inflammatory effects observed. The extract significantly inhibited paw edema formation in an acute model the rat. Our results also demonstrate that the standardized extract had pharmacological activity when administered orally in the collagen-induced arthritis model in the rat and was able to significantly reduce the development of clinical signs of arthritis and the degree of bone resorption, soft tissue swelling and osteophyte formation, consequently improving articular function in treated animals.
AB - Here we investigated the anti-inflammatory effect of a blueberry extract in the carrageenan-induced paw edema model and collagen-induced arthritis model, both in rats. Along with the chemical characterization of the phenolic content of the fruits and extract, the antioxidant potential of the extract, the cellular antioxidant activity and the effects over neutrophils’ oxidative burst, were studied in order to provide a mechanistic insight for the anti-inflammatory effects observed. The extract significantly inhibited paw edema formation in an acute model the rat. Our results also demonstrate that the standardized extract had pharmacological activity when administered orally in the collagen-induced arthritis model in the rat and was able to significantly reduce the development of clinical signs of arthritis and the degree of bone resorption, soft tissue swelling and osteophyte formation, consequently improving articular function in treated animals.
KW - Anti-inflammatory
KW - Blueberry fruit
KW - Collagen induced arthritis
KW - Oxidative burst
KW - Vaccinium corymbosum L.
UR - http://www.scopus.com/inward/record.url?scp=84989266756&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2016.08.040
DO - 10.1016/j.biopha.2016.08.040
M3 - Article
C2 - 27551767
AN - SCOPUS:84989266756
SN - 0753-3322
VL - 83
SP - 1191
EP - 1202
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
ER -
