Proliferation control in neural stem and progenitor cells

Catarina C.F. Homem, Marko Repic, Jürgen A. Knoblich

Research output: Contribution to journalReview articlepeer-review

180 Citations (Scopus)


Neural circuit function can be drastically affected by variations in the number of cells that are produced during development or by a reduction in adult cell number owing to disease. For this reason, unique cell cycle and cell growth control mechanisms operate in the developing and adult brain. In Drosophila melanogaster and in mammalian neural stem and progenitor cells, these mechanisms are intricately coordinated with the developmental age and the nutritional, metabolic and hormonal state of the animal. Defects in neural stem cell proliferation that result in the generation of incorrect cell numbers or defects in neural stem cell differentiation can cause microcephaly or megalencephaly.

Original languageEnglish
Pages (from-to)647-659
Number of pages13
JournalNature Reviews Neuroscience
Issue number11
Publication statusPublished - 1 Nov 2015


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