Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention

C. Ramos, Patrícia Napoleão, Mafalda Selas, Cláudia Freixo, Ana Maria Viegas-Crespo, Miguel Mota Carmo, Rui Cruz Ferreira, Teresa Pinheiro

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Abstract

We examined the longitudinal changes of VEGF levels after percutaneous coronary intervention for predicting major adverse cardiac events (MACE) in coronary artery disease (CAD) patients. VEGF was measured in 94 CAD patients' serum before revascularization, 1-month and 1-year after. Independently of clinical presentation, patients had lower VEGF concentration than a cohort of healthy subjects (median, IQ: 15.9, 9.0-264 pg/mL versus 419, 212-758 pg/mL; P < 0.001) at baseline. VEGF increased to 1-month (median, IQ: 276, 167-498 pg/mL; P < 0.001) and remained steady to 1-year (median, IQ: 320, 173-497 pg/mL; P < 0.001) approaching control levels. Drug eluting stent apposition and previous medication intake produced a less steep VEGF evolution after intervention (P < 0.05). Baseline VEGF concentration <40.8 pg/mL conveyed increased risk for MACE in a 5-year follow-up. Results reflect a positive role of VEGF in recovery and support its importance in CAD prognosis.
Original languageEnglish
Pages (from-to)Online
Number of pages7
JournalDisease Markers
Volume135357
Issue numberNA
DOIs
Publication statusPublished - 2014

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Percutaneous Coronary Intervention
Vascular Endothelial Growth Factor A
Coronary Artery Disease
Drug-Eluting Stents
Stents
Level control
Healthy Volunteers
Recovery
Serum
Pharmaceutical Preparations

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Ramos, C., Napoleão, P., Selas, M., Freixo, C., Viegas-Crespo, A. M., Carmo, M. M., ... Pinheiro, T. (2014). Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention. Disease Markers, 135357(NA), Online. https://doi.org/10.1155/2014/135357
Ramos, C. ; Napoleão, Patrícia ; Selas, Mafalda ; Freixo, Cláudia ; Viegas-Crespo, Ana Maria ; Carmo, Miguel Mota ; Ferreira, Rui Cruz ; Pinheiro, Teresa. / Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention. In: Disease Markers. 2014 ; Vol. 135357, No. NA. pp. Online.
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abstract = "We examined the longitudinal changes of VEGF levels after percutaneous coronary intervention for predicting major adverse cardiac events (MACE) in coronary artery disease (CAD) patients. VEGF was measured in 94 CAD patients' serum before revascularization, 1-month and 1-year after. Independently of clinical presentation, patients had lower VEGF concentration than a cohort of healthy subjects (median, IQ: 15.9, 9.0-264 pg/mL versus 419, 212-758 pg/mL; P < 0.001) at baseline. VEGF increased to 1-month (median, IQ: 276, 167-498 pg/mL; P < 0.001) and remained steady to 1-year (median, IQ: 320, 173-497 pg/mL; P < 0.001) approaching control levels. Drug eluting stent apposition and previous medication intake produced a less steep VEGF evolution after intervention (P < 0.05). Baseline VEGF concentration <40.8 pg/mL conveyed increased risk for MACE in a 5-year follow-up. Results reflect a positive role of VEGF in recovery and support its importance in CAD prognosis.",
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Ramos, C, Napoleão, P, Selas, M, Freixo, C, Viegas-Crespo, AM, Carmo, MM, Ferreira, RC & Pinheiro, T 2014, 'Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention', Disease Markers, vol. 135357, no. NA, pp. Online. https://doi.org/10.1155/2014/135357

Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention. / Ramos, C.; Napoleão, Patrícia; Selas, Mafalda; Freixo, Cláudia; Viegas-Crespo, Ana Maria; Carmo, Miguel Mota; Ferreira, Rui Cruz; Pinheiro, Teresa.

In: Disease Markers, Vol. 135357, No. NA, 2014, p. Online.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic Value of VEGF in Patients Submitted to Percutaneous Coronary Intervention

AU - Ramos, C.

AU - Napoleão, Patrícia

AU - Selas, Mafalda

AU - Freixo, Cláudia

AU - Viegas-Crespo, Ana Maria

AU - Carmo, Miguel Mota

AU - Ferreira, Rui Cruz

AU - Pinheiro, Teresa

N1 - info:eu-repo/grantAgreement/FCT/5646-ICCMS/82734/PT# The authors gratefully acknowledge the assistance of the staff of Servico de Cardiologia, Hospital de Santa Marta, and Ms. Rute Pinheiro for the help with laboratory work. The study was financially supported by Fundacao para a Ciencia e Tecnologia, PIC/IC/82734/2007 Contract and SFRM/BPD/6308/2009 Grant, and by Liga dos Amigos do Hospital de Santa Marta.

PY - 2014

Y1 - 2014

N2 - We examined the longitudinal changes of VEGF levels after percutaneous coronary intervention for predicting major adverse cardiac events (MACE) in coronary artery disease (CAD) patients. VEGF was measured in 94 CAD patients' serum before revascularization, 1-month and 1-year after. Independently of clinical presentation, patients had lower VEGF concentration than a cohort of healthy subjects (median, IQ: 15.9, 9.0-264 pg/mL versus 419, 212-758 pg/mL; P < 0.001) at baseline. VEGF increased to 1-month (median, IQ: 276, 167-498 pg/mL; P < 0.001) and remained steady to 1-year (median, IQ: 320, 173-497 pg/mL; P < 0.001) approaching control levels. Drug eluting stent apposition and previous medication intake produced a less steep VEGF evolution after intervention (P < 0.05). Baseline VEGF concentration <40.8 pg/mL conveyed increased risk for MACE in a 5-year follow-up. Results reflect a positive role of VEGF in recovery and support its importance in CAD prognosis.

AB - We examined the longitudinal changes of VEGF levels after percutaneous coronary intervention for predicting major adverse cardiac events (MACE) in coronary artery disease (CAD) patients. VEGF was measured in 94 CAD patients' serum before revascularization, 1-month and 1-year after. Independently of clinical presentation, patients had lower VEGF concentration than a cohort of healthy subjects (median, IQ: 15.9, 9.0-264 pg/mL versus 419, 212-758 pg/mL; P < 0.001) at baseline. VEGF increased to 1-month (median, IQ: 276, 167-498 pg/mL; P < 0.001) and remained steady to 1-year (median, IQ: 320, 173-497 pg/mL; P < 0.001) approaching control levels. Drug eluting stent apposition and previous medication intake produced a less steep VEGF evolution after intervention (P < 0.05). Baseline VEGF concentration <40.8 pg/mL conveyed increased risk for MACE in a 5-year follow-up. Results reflect a positive role of VEGF in recovery and support its importance in CAD prognosis.

KW - MOLECULAR-MECHANISMS

KW - SERUM-LEVELS

KW - VASCULAR-PERMEABILITY

KW - MOBILIZATION

KW - ENDOTHELIAL-GROWTH-FACTOR

KW - ANGIOGENESIS

KW - DYSFUNCTION

KW - ARTERY-DISEASE

KW - FACTOR-A

KW - CLINICAL-APPLICATIONS

U2 - 10.1155/2014/135357

DO - 10.1155/2014/135357

M3 - Article

VL - 135357

SP - Online

JO - Disease Markers

JF - Disease Markers

SN - 0278-0240

IS - NA

ER -