TY - JOUR
T1 - Prognostic value of kappa free light chains determination in first-ever multiple sclerosis relapse
AU - Salavisa, Manuel
AU - Paixão, Pedro
AU - Ladeira, Ana Filipa
AU - Mendes, Alexandra
AU - Correia, Ana Sofia
AU - Viana, João Faro
AU - Viana-Baptista, Miguel
PY - 2020/10/15
Y1 - 2020/10/15
N2 - Given its highly variable clinical course, an unmet need for objective prognostic assessment in Multiple Sclerosis (MS) persists. In this work, we suggest that CSF kappa free light chains (KFLC) determination at first relapse may provide insight into future disease activity and disability worsening. We quantified KFLC by nephelometry in paired CSF/serum samples of 28 patients, collected within one month of first-ever MS relapse, and explored correlations with clinical data on disease activity, retrospectively registered across a median follow-up time of 79 months. We documented KFLC ratio (CSF-FKLC/Serum-KFLC) as an independent predictor of second relapse occurrence and disability worsening at follow-up, in this cohort.
AB - Given its highly variable clinical course, an unmet need for objective prognostic assessment in Multiple Sclerosis (MS) persists. In this work, we suggest that CSF kappa free light chains (KFLC) determination at first relapse may provide insight into future disease activity and disability worsening. We quantified KFLC by nephelometry in paired CSF/serum samples of 28 patients, collected within one month of first-ever MS relapse, and explored correlations with clinical data on disease activity, retrospectively registered across a median follow-up time of 79 months. We documented KFLC ratio (CSF-FKLC/Serum-KFLC) as an independent predictor of second relapse occurrence and disability worsening at follow-up, in this cohort.
KW - Disease activity
KW - Kappafree light chains
KW - MS biomarkers
KW - Multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=85089227740&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2020.577355
DO - 10.1016/j.jneuroim.2020.577355
M3 - Article
C2 - 32795735
AN - SCOPUS:85089227740
VL - 347
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
M1 - 577355
ER -