Production of Electrospun Fast-Dissolving Drug Delivery Systems with Therapeutic Eutectic Systems Encapsulated in Gelatin

Francisca Mano, Marta Martins, Isabel Sá-Nogueira, Susana Barreiros, João Paulo Borges, Rui L. Reis, Ana Rita C Duarte, Alexandre Paiva

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Fast-dissolving delivery systems (FDDS) have received increasing attention in the last years. Oral drug delivery is still the preferred route for the administration of pharmaceutical ingredients. Nevertheless, some patients, e.g. children or elderly people, have difficulties in swallowing solid tablets. In this work, gelatin membranes were produced by electrospinning, containing an encapsulated therapeutic deep-eutectic solvent (THEDES) composed by choline chloride/mandelic acid, in a 1:2 molar ratio. A gelatin solution (30% w/v) with 2% (v/v) of THEDES was used to produce electrospun fibers and the experimental parameters were optimized. Due to the high surface area of polymer fibers, this type of construct has wide applicability. With no cytotoxicity effect, and showing a fast-dissolving release profile in PBS, the gelatin fibers with encapsulated THEDES seem to have promising applications in the development of new drug delivery systems.

Original languageEnglish
Pages (from-to)2579-2585
Number of pages7
JournalAAPS PharmSciTech
Volume18
Issue number7
DOIs
Publication statusAccepted/In press - 24 Feb 2017

Keywords

  • anti-bacterial studies
  • fast-dissolving drug delivery systems
  • gelatin
  • mandelic acid
  • therapeutic deep-eutectic solvents

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