Production of copper loaded lipid microparticles by PGSS® (particles from gas satured solutions) process

Víctor Martín, Vanessa Gonçalves, Soraya Rodríguez-Rojo, Daniela Nunes, Elvira Fortunato, Rodrigo Martins, María José Cocero, Catarina Duarte

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Production of lipid particles loaded with metal nanoparticles by supercritical fluids based processes has been barely studied. In this work, copper nanoparticles were loaded into glyceryl palmitostearate microparticles by PGSS® (Particles from Gas Saturated Solutions). The effect of different variables, temperature (60–80 °C), copper load (0.2–5%w/w) and water addition (0–40%w/w), in particle size and encapsulation efficiency has been studied. The dispersion of metal nanoparticles in the lipid has been determined by SEM-FIB coupled with EDS mapping. In all cases, mean particle size values lower than 70 μm have been obtained, and encapsulation efficiencies around 60% have been achieved. The addition of water has no negative effect in encapsulation efficiency nor in nanoparticles dispersion within the lipid microparticle, being important since nanoparticles are commonly synthetized in aqueous medium.

Original languageEnglish
Pages (from-to)124-129
Number of pages6
JournalJournal of Supercritical Fluids
Volume131
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

microparticles
Encapsulation
Lipids
lipids
Copper
Metal nanoparticles
Gases
Nanoparticles
copper
nanoparticles
Particle size
gases
Supercritical fluids
Water
Energy dispersive spectroscopy
supercritical fluids
Scanning electron microscopy
metals
water
scanning electron microscopy

Keywords

  • Copper nanoparticles encapsulation
  • Dispersion
  • Lipid microparticles
  • PGSS

Cite this

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title = "Production of copper loaded lipid microparticles by PGSS{\circledR} (particles from gas satured solutions) process",
abstract = "Production of lipid particles loaded with metal nanoparticles by supercritical fluids based processes has been barely studied. In this work, copper nanoparticles were loaded into glyceryl palmitostearate microparticles by PGSS{\circledR} (Particles from Gas Saturated Solutions). The effect of different variables, temperature (60–80 °C), copper load (0.2–5{\%}w/w) and water addition (0–40{\%}w/w), in particle size and encapsulation efficiency has been studied. The dispersion of metal nanoparticles in the lipid has been determined by SEM-FIB coupled with EDS mapping. In all cases, mean particle size values lower than 70 μm have been obtained, and encapsulation efficiencies around 60{\%} have been achieved. The addition of water has no negative effect in encapsulation efficiency nor in nanoparticles dispersion within the lipid microparticle, being important since nanoparticles are commonly synthetized in aqueous medium.",
keywords = "Copper nanoparticles encapsulation, Dispersion, Lipid microparticles, PGSS",
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Production of copper loaded lipid microparticles by PGSS® (particles from gas satured solutions) process. / Martín, Víctor; Gonçalves, Vanessa; Rodríguez-Rojo, Soraya; Nunes, Daniela; Fortunato, Elvira; Martins, Rodrigo; Cocero, María José; Duarte, Catarina.

In: Journal of Supercritical Fluids, Vol. 131, 01.01.2018, p. 124-129.

Research output: Contribution to journalArticle

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AU - Martín, Víctor

AU - Gonçalves, Vanessa

AU - Rodríguez-Rojo, Soraya

AU - Nunes, Daniela

AU - Fortunato, Elvira

AU - Martins, Rodrigo

AU - Cocero, María José

AU - Duarte, Catarina

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