Production and characterization of chitosan/calcium phosphate composite microspheres for bone tissue engineering therapeutics

Jorge Alexandre Monteiro de Carvalho Silva; João Paulo Miranda Ribeiro Borges

Production and characterization of chitosan/calcium phosphate composite microspheres for bone tissue engineering therapeutics

Jorge Alexandre Monteiro de Carvalho Silva, João Paulo Miranda Ribeiro Borges

Research output: Other contribution

Abstract

In this work chitosan/calcium phosphates (CS/CP) composite microspheres were produced. The calcium phosphates used were hydroxyapatite (HAp) and b-tricalcium phosphate (b-TCP). Acetylsalicylic acid, a model drug, was encapsulated in the microspheres in order to determine the therapeutic efficacy of the microspheres. CPs were produced by sol-gel method and microspheres were produced by microfluidics. The microspheres were characterized in terms of morphology by scanning electronic microscopy (SEM) and optical microscopy. Encapsulation efficiency and drug delivery profile were studied. CS microspheres with an average diameter of 337 lm and a smooth surface were obtained. The composite microspheres with different amounts of HAp and b-TCP presented the same morphology but a rough surface due to the presence of the ceramics. The microspheres released about 20% of the drug on the first day and about 50% of the drug in 16 days. These results seem to reveal that a surface erosion mechanism is responsible for the drug release. Results will be interpreted on the basis of data available in literature.

Original language	Unknown
Volume	6
Publication status	Published - 1 Jan 2012

Cite this

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title = "Production and characterization of chitosan/calcium phosphate composite microspheres for bone tissue engineering therapeutics",

abstract = "In this work chitosan/calcium phosphates (CS/CP) composite microspheres were produced. The calcium phosphates used were hydroxyapatite (HAp) and b-tricalcium phosphate (b-TCP). Acetylsalicylic acid, a model drug, was encapsulated in the microspheres in order to determine the therapeutic efficacy of the microspheres. CPs were produced by sol-gel method and microspheres were produced by microfluidics. The microspheres were characterized in terms of morphology by scanning electronic microscopy (SEM) and optical microscopy. Encapsulation efficiency and drug delivery profile were studied. CS microspheres with an average diameter of 337 lm and a smooth surface were obtained. The composite microspheres with different amounts of HAp and b-TCP presented the same morphology but a rough surface due to the presence of the ceramics. The microspheres released about 20% of the drug on the first day and about 50% of the drug in 16 days. These results seem to reveal that a surface erosion mechanism is responsible for the drug release. Results will be interpreted on the basis of data available in literature.",

author = "Silva, {Jorge Alexandre Monteiro de Carvalho} and Borges, {Jo{\~a}o Paulo Miranda Ribeiro}",

year = "2012",

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volume = "6",

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TY - GEN

T1 - Production and characterization of chitosan/calcium phosphate composite microspheres for bone tissue engineering therapeutics

AU - Silva, Jorge Alexandre Monteiro de Carvalho

AU - Borges, João Paulo Miranda Ribeiro

PY - 2012/1/1

Y1 - 2012/1/1

N2 - In this work chitosan/calcium phosphates (CS/CP) composite microspheres were produced. The calcium phosphates used were hydroxyapatite (HAp) and b-tricalcium phosphate (b-TCP). Acetylsalicylic acid, a model drug, was encapsulated in the microspheres in order to determine the therapeutic efficacy of the microspheres. CPs were produced by sol-gel method and microspheres were produced by microfluidics. The microspheres were characterized in terms of morphology by scanning electronic microscopy (SEM) and optical microscopy. Encapsulation efficiency and drug delivery profile were studied. CS microspheres with an average diameter of 337 lm and a smooth surface were obtained. The composite microspheres with different amounts of HAp and b-TCP presented the same morphology but a rough surface due to the presence of the ceramics. The microspheres released about 20% of the drug on the first day and about 50% of the drug in 16 days. These results seem to reveal that a surface erosion mechanism is responsible for the drug release. Results will be interpreted on the basis of data available in literature.

AB - In this work chitosan/calcium phosphates (CS/CP) composite microspheres were produced. The calcium phosphates used were hydroxyapatite (HAp) and b-tricalcium phosphate (b-TCP). Acetylsalicylic acid, a model drug, was encapsulated in the microspheres in order to determine the therapeutic efficacy of the microspheres. CPs were produced by sol-gel method and microspheres were produced by microfluidics. The microspheres were characterized in terms of morphology by scanning electronic microscopy (SEM) and optical microscopy. Encapsulation efficiency and drug delivery profile were studied. CS microspheres with an average diameter of 337 lm and a smooth surface were obtained. The composite microspheres with different amounts of HAp and b-TCP presented the same morphology but a rough surface due to the presence of the ceramics. The microspheres released about 20% of the drug on the first day and about 50% of the drug in 16 days. These results seem to reveal that a surface erosion mechanism is responsible for the drug release. Results will be interpreted on the basis of data available in literature.

M3 - Other contribution

VL - 6

ER -