TY - JOUR
T1 - Prodrug polymeric nanoconjugates encapsulating gold nanoparticles for enhanced X-Ray radiation therapy in breast cancer
AU - Nosrati, Hamed
AU - Seidi, Farzad
AU - Hosseinmirzaei, Ali
AU - Mousazadeh, Navid
AU - Mohammadi, Ali
AU - Ghaffarlou, Mohammadreza
AU - Danafar, Hossein
AU - Conde, João
AU - Sharafi, Ali
N1 - This article is protected by copyright. All rights reserved.
PY - 2022/2/2
Y1 - 2022/2/2
N2 - An optimal radiosensitizer with improved tumor retention have an important effect in tumor radiation therapy. Herein, gold nanoparticles (Au NPs) and drug containing, mPEG-conjugated CUR (mPEG-CUR), self-assembled NPs (mPEG-CUR@Au) were developed and evaluated as a drug carrier and radiosensitizer in a breast cancer mice model. As a result, cancer therapy efficacy was improved significantly by applying all-in-one NPs to achieve synchronous chemoradiotherapy, as evidenced by studies evaluating cell viability, proliferation, and ROS production. In vivo anticancer experiments showed that the mPEG-CUR@Au system improves the radiation sensitivity of 4T1 mammary carcinoma and completely abrogates breast cancer. This article is protected by copyright. All rights reserved.
AB - An optimal radiosensitizer with improved tumor retention have an important effect in tumor radiation therapy. Herein, gold nanoparticles (Au NPs) and drug containing, mPEG-conjugated CUR (mPEG-CUR), self-assembled NPs (mPEG-CUR@Au) were developed and evaluated as a drug carrier and radiosensitizer in a breast cancer mice model. As a result, cancer therapy efficacy was improved significantly by applying all-in-one NPs to achieve synchronous chemoradiotherapy, as evidenced by studies evaluating cell viability, proliferation, and ROS production. In vivo anticancer experiments showed that the mPEG-CUR@Au system improves the radiation sensitivity of 4T1 mammary carcinoma and completely abrogates breast cancer. This article is protected by copyright. All rights reserved.
U2 - 10.1002/adhm.202102321
DO - 10.1002/adhm.202102321
M3 - Article
C2 - 34800003
SN - 2192-2640
VL - 11
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
IS - 3
M1 - e2102321
ER -