Processing triacetyl-β-cyclodextrin in the liquid phase using supercritical CO2

Ana V. M. Nunes, Ana P. C. Almeida, S. R. Marques, Andreina R. Sampaio de Sousa, Teresa Casimiro, Catarina M. M. Duarte

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15 Citations (Scopus)


TA-β-CD has been proposed as an effective sustained release carrier for highly water soluble drugs with short biological half-lives. In this work, the possibility of preparing drug - triacetyl-β-cyclodextrin (TA-β-CD) complexes in the liquid phase by exploring its solid-liquid-gas equilibrium (S-L-G) under supercritical CO2 atmosphere was evaluated. The S-L-G equilibrium line for the binary system TA-β-CD + CO2 was determined by a visual method for pressures up to 25.3 MPa. At the studied conditions, a homogeneous and translucent liquid phase emerge at 307 K when exposed to CO2 pressurized at 16 MPa and this temperature further increases with increasing pressure, up to 318 K at 25.3 MPa. The S-L-G equilibrium behaviour observed is typical of this kind of asymmetric systems, it is totally CO2 density-dependent and opens the possibility of further processing TA-β-CD in the liquid phase. In order to investigate the possibility of preparing a drug-TA-β-CD complex in the liquid phase of TA-β-CD, a preliminary experiment was performed at 25 MPa and 308 K using flufenamic acid (FA) as the model active principle.

Original languageEnglish
Pages (from-to)357-361
Number of pages5
JournalJournal of Supercritical Fluids
Issue number3(SI)
Publication statusPublished - Sept 2010
EventWorkshop on Supercritical Fluid Processing of Biopolymers and Biomedical Materials - Madeira, Portugal
Duration: 16 Nov 201017 Nov 2010


  • Solid-liquid-gas equilibrium
  • Sustained release
  • Triacetyl-β-cyclodextrin


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