Processing triacetyl-β-cyclodextrin in the liquid phase using supercritical CO2

A. V. M. Nunes, A. P. C. Almeida, S. R. Marques, Andreina R. Sampaio de Sousa, T. Casimiro, Catarina M. M. Duarte

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

TA-β-CD has been proposed as an effective sustained release carrier for highly water soluble drugs with short biological half-lives. In this work, the possibility of preparing drug - triacetyl-β-cyclodextrin (TA-β-CD) complexes in the liquid phase by exploring its solid-liquid-gas equilibrium (S-L-G) under supercritical CO2 atmosphere was evaluated. The S-L-G equilibrium line for the binary system TA-β-CD + CO2 was determined by a visual method for pressures up to 25.3 MPa. At the studied conditions, a homogeneous and translucent liquid phase emerge at 307 K when exposed to CO2 pressurized at 16 MPa and this temperature further increases with increasing pressure, up to 318 K at 25.3 MPa. The S-L-G equilibrium behaviour observed is typical of this kind of asymmetric systems, it is totally CO2 density-dependent and opens the possibility of further processing TA-β-CD in the liquid phase. In order to investigate the possibility of preparing a drug-TA-β-CD complex in the liquid phase of TA-β-CD, a preliminary experiment was performed at 25 MPa and 308 K using flufenamic acid (FA) as the model active principle.

Original languageEnglish
Pages (from-to)357-361
Number of pages5
JournalJournal of Supercritical Fluids
Volume54
Issue number3(SI)
DOIs
Publication statusPublished - 1 Jan 2010
EventWorkshop on Supercritical Fluid Processing of Biopolymers and Biomedical Materials - Madeira, Portugal
Duration: 16 Nov 201017 Nov 2010

Keywords

  • Solid-liquid-gas equilibrium
  • Sustained release
  • Triacetyl-β-cyclodextrin

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